Search Results - "Dencker, Lennart"
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1
Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes
Published in BMC biology (20-09-2007)“…The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes, and…”
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Effects of the histone deacetylase inhibitor valproic acid on human pericytes in vitro
Published in PloS one (22-09-2011)“…Microvascular pericytes are of key importance in neoformation of blood vessels, in stabilization of newly formed vessels as well as maintenance of angiostasis…”
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3
Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex
Published in Neurotoxicology (Park Forest South) (01-07-2008)“…Polybrominated diphenyl ethers (PBDEs) are environmental contaminants found in human and animal tissues worldwide. Neonatal exposure to the flame retardant…”
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4
Valproic Acid Teratogenicity: A Toxicogenomics Approach
Published in Environmental health perspectives (15-08-2004)“…Embryonic development is a highly coordinated set of processes that depend on hierarchies of signaling and gene regulatory networks, and the disruption of such…”
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5
Sex-dependent gene expression in early brain development of chicken embryos
Published in BMC neuroscience (15-02-2006)“…Differentiation of the brain during development leads to sexually dimorphic adult reproductive behavior and other neural sex dimorphisms. Genetic mechanisms…”
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6
Valproic Acid Teratogenicity: A Toxicogenomics Approach
Published in Environmental health perspectives (01-08-2004)“…Embryonic development is a highly coordinated set of processes that depend on hierarchies of signaling and gene regulatory networks, and the disruption of such…”
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7
The Identification of a 9-cis Retinol Dehydrogenase in the Mouse Embryo Reveals a Pathway for Synthesis of 9-cis Retinoic Acid
Published in Proceedings of the National Academy of Sciences - PNAS (14-04-1998)“…The ligand-controlled retinoic acid (RA) receptors and retinoid X receptors are important for several physiological processes, including normal embryonic…”
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The cellular retinoic acid binding proteins
Published in Journal of steroid biochemistry and molecular biology (01-06-1995)“…The two cellular retinoic acid binding proteins, CRABP I and CRABP II, belong to a family of small cytosolic lipid binding proteins and are highly conserved…”
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9
Valproic Acid–Induced Deregulation In Vitro of Genes Associated In Vivo with Neural Tube Defects
Published in Toxicological sciences (01-03-2009)“…The utility of an in vitro system to search for molecular targets and markers of developmental toxicity was explored, using microarrays to detect genes…”
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Metabolism of arsenobetaine in mice, rats and rabbits
Published in The Science of the total environment (01-09-1983)“…The distribution, retention and biotransformation of arsenobetaine, the most common organic arsenic compound in fish and crustacea, have been studied in mice,…”
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11
Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells
Published in Toxicological sciences (01-06-2011)“…Prediction of developmental toxicity in vitro could be based on short-time toxicogenomic endpoints in embryo-derived cell lines. Microarray studies in P19…”
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12
Mercury in the Spinal Cord After Inhalation of Mercury
Published in Basic & clinical pharmacology & toxicology (01-08-2012)“…Amyotrophic lateral sclerosis (ALS) affects anterior horn cells of the spinal cord causing an indolent slow and steady deterioration of muscle strength leading…”
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Position Paper: EUFEPS Network on Veterinary Medicines Initiative: An interdisciplinary forum to support Veterinary Pharmacology and promote the development of new pharmaceuticals for Animal Health
Published in European journal of pharmaceutical sciences (2016)“…Veterinary medicines account for a substantial portion of the production, sale, and consumption of medicines in Europe, and probably world-wide. This calls our…”
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Towards a European Strategy for Medicines Research (2014–2020): The EUFEPS Position Paper on Horizon 2020
Published in European journal of pharmaceutical sciences (18-12-2012)“…Executive summary: As to the alignment of “Horizon 2020”, ir is a more integrated approach to European science policy than expressed in the proposals…”
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Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences
Published in Journal of veterinary pharmacology and therapeutics (01-06-2018)“…The European Federation for Pharmaceutical Sciences (EUFEPS) was founded 25 years ago by more than 20 national pharmaceutical societies and faculty members. As…”
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16
Metabolism of arsenocholine in mice, rats and rabbits
Published in The Science of the total environment (01-01-1984)“…The distribution, retention and biotransformation of arsenocholine, an organic arsenic compound present in certain seafood, have been studied in rats, mice and…”
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Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity
Published in Reproductive toxicology (Elmsford, N.Y.) (01-11-2010)“…Cell-based in vitro assays would potentially reduce animal testing in preclinical drug development. Mouse embryos exposed to the teratogenic drug valproic acid…”
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Proteomic Evaluation of Neonatal Exposure to 2,2′,4,4′,5-Pentabromodiphenyl Ether
Published in Environmental health perspectives (01-02-2006)“…Exposure to the brominated flame retardant 2,2′,4,4′,5-pentabromodiphenyl ether (PBDE-99) during the brain growth spurt disrupts normal brain development in…”
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In Vitro Neurotoxicity of PBDE-99: Immediate and Concentration-Dependent Effects on Protein Expression in Cerebral Cortex Cells
Published in Journal of proteome research (05-03-2010)“…Polybrominated diphenyl ethers (PBDEs) are commonly used flame retardants in various consumer products. Pre- and postnatal exposure to congeners of PBDEs…”
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A novel infrastructure for chemical safety predictions with focus on human health
Published in TOXICOLOGY LETTERS (2012)“…A major objective of Computational Toxicology is to provide reliable and useful estimates in silico of (potentially) harmful actions of chemicals in humans…”
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