Search Results - "Denby, Laura"

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease by Conway, Bryan R, O'Sullivan, Eoin D, Cairns, Carolynn, O'Sullivan, James, Simpson, Daniel J, Salzano, Angela, Connor, Katie, Ding, Peng, Humphries, Duncan, Stewart, Kevin, Teenan, Oliver, Pius, Riinu, Henderson, Neil C, Bénézech, Cécile, Ramachandran, Prakash, Ferenbach, David, Hughes, Jeremy, Chandra, Tamir, Denby, Laura

“…Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells…”
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Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants by Jackson-Jones, Lucy Helen, Smith, Peter, Portman, Jordan Raymond, Magalhaes, Marlène Sophie, Mylonas, Katie Jude, Vermeren, Matthieu Marie, Nixon, Mark, Henderson, Beth Emily Pollot, Dobie, Ross, Vermeren, Sonja, Denby, Laura, Henderson, Neil Cowan, Mole, Damian James, Bénézech, Cécile

“…The omentum is a visceral adipose tissue rich in fat-associated lymphoid clusters (FALCs) that collects peritoneal contaminants and provides a first layer of…”
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Beta Blockade Prevents Cardiac Morphological and Molecular Remodelling in Experimental Uremia by Chinnappa, Shanmugakumar, Maqbool, Azhar, Viswambharan, Hema, Mooney, Andrew, Denby, Laura, Drinkhill, Mark

“…Heart failure and chronic kidney disease (CKD) share several mediators of cardiac pathological remodelling. Akin to heart failure, this remodelling sets in…”
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IL-33 reduces the development of atherosclerosis by Miller, Ashley M, Xu, Damo, Asquith, Darren L, Denby, Laura, Li, Yubin, Sattar, Naveed, Baker, Andrew H, McInnes, Iain B, Liew, Foo Y

“…Atherosclerosis is a chronic inflammatory disease of the vasculature commonly leading to myocardial infarction and stroke. We show that IL-33, which is a novel…”
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Urinary angiotensinogen as a biomarker for acute to chronic kidney injury transition - prognostic and mechanistic implications by Connor, Katie L, Denby, Laura

“…Accurate biomarkers that both predict the progression to, and detect the early stages of chronic kidney disease (CKD) are lacking, resulting in difficulty in…”
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Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling by de la Cuesta, Fernando, Passalacqua, Ilaria, Rodor, Julie, Bhushan, Raghu, Denby, Laura, Baker, Andrew H

“…Excessive TGF-β signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release…”
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Dynamic Changes in Lung MicroRNA Profiles During the Development of Pulmonary Hypertension due to Chronic Hypoxia and Monocrotaline by Caruso, Paola, MacLean, Margaret R, Khanin, Raya, McClure, John, Soon, Elaine, Southgate, Mark, MacDonald, Robert A, Greig, Jenny A, Robertson, Keith E, Masson, Rachel, Denby, Laura, Dempsie, Yvonne, Long, Lu, Morrell, Nicholas W, Baker, Andrew H

“…OBJECTIVE—MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding “seed” sequences within a target…”
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P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats by Nespoux, Josselin, Monaghan, Marie-Louise T., Jones, Natalie K., Stewart, Kevin, Denby, Laura, Czopek, Alicja, Mullins, John J., Menzies, Robert I., Baker, Andrew H., Bailey, Matthew A.

“…P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration…”
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Renal disease pathophysiology and treatment: contributions from the rat by Mullins, Linda J, Conway, Bryan R, Menzies, Robert I, Denby, Laura, Mullins, John J

“…The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on…”
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miR-21 and miR-214 Are Consistently Modulated during Renal Injury in Rodent Models by Denby, Laura, Ramdas, Vasudev, McBride, Martin W, Wang, Joe, Robinson, Hollie, McClure, John, Crawford, Wendy, Lu, Ruifang, Hillyard, Dianne Z, Khanin, Raya, Agami, Reuven, Dominiczak, Anna F, Sharpe, Claire C, Baker, Andrew H

“…Transforming growth factor (TGF)-β is one of the main fibrogenic cytokines that drives the pathophysiology of progressive renal scarring. MicroRNAs (miRNAs)…”
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Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes by Parker, Alan L., Waddington, Simon N., Nicol, Campbell G., Shayakhmetov, Dmitry M., Buckley, Suzanne M., Denby, Laura, Kemball-Cook, Geoffrey, Ni, Shaoheng, Lieber, Andre, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.

“…Upon local delivery, adenovirus (Ad) serotype 5 viruses use the coxsackie and Ad receptor (CAR) for cell binding and αv integrins for internalization. When…”
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Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction by O'Sullivan, James, Finnie, Sarah Louise, Teenan, Oliver, Cairns, Carolynn, Boyd, Andrew, Bailey, Matthew A, Thomson, Adrian, Hughes, Jeremy, Bénézech, Cécile, Conway, Bryan Ronald, Denby, Laura

“…Chronic kidney disease (CKD) is prevalent worldwide and is associated with significant co-morbidities including cardiovascular disease (CVD). Traditionally,…”
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Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors by Alba, Raul, Bradshaw, Angela C., Coughlan, Lynda, Denby, Laura, McDonald, Robert A., Waddington, Simon N., Buckley, Suzanne M.K., Greig, Jenny A., Parker, Alan L., Miller, Ashley M., Wang, Hongjie, Lieber, Andre, van Rooijen, Nico, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.

“…A major limitation for adenoviral transduction in vivo is the profound liver tropism of adenovirus type 5 (Ad5). Recently, we demonstrated that coagulation…”
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Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells by Matthews, Olivia, Morrison, Emma E., Tranter, John D., Starkey Lewis, Philip, Toor, Iqbal S., Srivastava, Abhishek, Sargeant, Rebecca, Rollison, Helen, Matchett, Kylie P., Kendall, Timothy J., Gray, Gillian A., Goldring, Chris, Park, Kevin, Denby, Laura, Dhaun, Neeraj, Bailey, Matthew A., Henderson, Neil C., Williams, Dominic, Dear, James W.

“…Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to…”
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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis by O'Sullivan, Eoin D, Mylonas, Katie J, Bell, Rachel, Carvalho, Cyril, Baird, David P, Cairns, Carolynn, Gallagher, Kevin M, Campbell, Ross, Docherty, Marie, Laird, Alexander, Henderson, Neil C, Chandra, Tamir, Kirschner, Kristina, Conway, Bryan, Dihazi, Gry H, Zeisberg, Michael, Hughes, Jeremy, Denby, Laura, Dihazi, Hassan, Ferenbach, David A

“…Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with…”
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Identifying cell-enriched miRNAs in kidney injury and repair by Connor, Katie L, Teenan, Oliver, Cairns, Carolynn, Banwell, Victoria, Thomas, Rachel Ab, Rodor, Julie, Finnie, Sarah, Pius, Riinu, Tannahill, Gillian M, Sahni, Vishal, Savage, Caroline Os, Hughes, Jeremy, Harrison, Ewen M, Henderson, Robert B, Marson, Lorna P, Conway, Bryan R, Wigmore, Stephen J, Denby, Laura

“…Small noncoding RNAs, miRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney…”
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Regulation and Function of miR-214 in Pulmonary Arterial Hypertension by Stevens, Hannah C., Deng, Lin, Grant, Jennifer S., Pinel, Karine, Thomas, Matthew, Morrell, Nicholas W., MacLean, Margaret R., Baker, Andrew H., Denby, Laura

“…Dysregulation of microRNAs (miRNAs) can contribute to the etiology of diseases, including pulmonary arterial hypertension (PAH). Here we investigated a…”
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Development of Renal-targeted Vectors Through Combined In Vivo Phage Display and Capsid Engineering of Adenoviral Fibers From Serotype 19p by Denby, Laura, Work, Lorraine M, Seggern, Dan J Von, Wu, Eugene, McVey, John H, Nicklin, Stuart A, Baker, Andrew H

“…The potential efficacy of gene delivery is dictated by the infectivity profile of existing vectors, which is often restrictive. In order to target cells and…”
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2607 Generation of a tissue resident macrophage depleted reporter rat to examine cardiovascular homeostasis and kidney disease by Hur, Heeyoun, Hadoke, Patrick, Pridans, Clare, Denby, Laura

“…Abstract Cardiovascular disease (CVD) and chronic kidney disease (CKD) are currently the 1st and 10th leading cause of global mortality, respectively. By 2050,…”
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Elucidating the Function of a Novel Arg-1+/Clec4d+ Scar-Associated Monocyte-Derived Macrophage Population in Driving Fibrosis in Kidney Disease Models: FR-PO1066 by Bell, Rachel, Denby, Laura, Conway, Bryan, Bénézech, Cécile

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