Search Results - "Denbeigh, Janet M."

Vitamin C epigenetically controls osteogenesis and bone mineralization by Thaler, Roman, Khani, Farzaneh, Sturmlechner, Ines, Dehghani, Sharareh S., Denbeigh, Janet M., Zhou, Xianhu, Pichurin, Oksana, Dudakovic, Amel, Jerez, Sofia S., Zhong, Jian, Lee, Jeong-Heon, Natarajan, Ramesh, Kalajzic, Ivo, Jiang, Yong-hui, Deyle, David R., Paschalis, Eleftherios P., Misof, Barbara M., Ordog, Tamas, van Wijnen, Andre J.

“…Vitamin C deficiency disrupts the integrity of connective tissues including bone. For decades this function has been primarily attributed to Vitamin C as a…”
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MicroRNA-101a enhances trabecular bone accrual in male mice by Dudakovic, Amel, Jerez, Sofia, Deosthale, Padmini J., Denbeigh, Janet M., Paradise, Christopher R., Gluscevic, Martina, Zan, Pengfei, Begun, Dana L., Camilleri, Emily T., Pichurin, Oksana, Khani, Farzaneh, Thaler, Roman, Lian, Jane B., Stein, Gary S., Westendorf, Jennifer J., Plotkin, Lilian I., van Wijnen, Andre J.

“…High-throughput microRNA sequencing was performed during differentiation of MC3T3-E1 osteoblasts to develop working hypotheses for specific microRNAs that…”
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Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone by Soreide, Endre, Denbeigh, Janet M., Lewallen, Eric A., Samsonraj, Rebekah M., Berglund, Lawrence J., Dudakovic, Amel, Cool, Simon M., Nordsletten, Lars, Kakar, Sanjeev, van Wijnen, Andre J.

“…Tendon graft healing in bone tunnels for the fixation of intra‐articular ligament reconstructions may limit clinical outcome by delaying healing. This study…”
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A multi-chamber tissue culture device for load-dependent parallel evaluation of tendon explants by Soreide, Endre, Denbeigh, Janet M, Lewallen, Eric A, Thaler, Roman, Samsonraj, Rebekah M, Jones, Dakota L, Xu, Wei, Larson, Dirk, Nordsletten, Lars, Kakar, Sanjeev, van Wijnen, Andre J

“…Injuries in the musculoskeletal system, such as tendon and ligament ruptures, are challenging to manage and often require surgical reconstructions with limited…”
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VEGFR2-Targeted Molecular Imaging in the Mouse Embryo: An Alternative to the Tumor Model by Denbeigh, Janet M, Nixon, Brian A, Hudson, John M, Puri, Mira C, Foster, F. Stuart

“…Abstract As a tumor surrogate, the mouse embryo presents as an excellent alternative for examining the binding of angiogenesis-targeting microbubbles and…”
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A High-Precision Method for In Vitro Proton Irradiation by Howard, Michelle E, Denbeigh, Janet M, Debrot, Emily K, Remmes, Nicholas B, Herman, Michael G, Beltran, Chris J

“…Although proton therapy has become a well-established radiation modality, continued efforts are needed to improve our understanding of the molecular and…”
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DNA Double-Strand Break Repair Kinetics after Exposure to Photons and Ions: A Systematic Review by Radstake, Wilhelmina E., Parisi, Alessio, Denbeigh, Janet M., Furutani, Keith M., Beltran, Chris J.

“…This study offers a review of published data on DNA double strand break (DSB) repair kinetics after exposure to ionizing radiation. By compiling a database,…”
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Multiphasic scaffold for scapholunate interosseous ligament reconstruction: A study in the rabbit knee by Lui, Hayman, Vaquette, Cedryck, Denbeigh, Janet M., Bindra, Randy, Kakar, Sanjeev, Wijnen, Andre J.

“…Scapholunate interosseous ligament tears are a common wrist injury in young and active patients that can lead to suboptimal outcomes after repair. This…”
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Exploring the LET dependence of DNA DSB repair kinetics using the DR DNA database by Radstake, Wilhelmina E, Parisi, Alessio, Denbeigh, Janet M, Beltran, Chris J, Furutani, Keith M

“…Abstract The repair of DNA double-strand breaks is a crucial yet delicate process which is affected by a multitude of factors. In this study, our goal is to…”
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Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining by Zhou, Qin, Howard, Michelle E, Tu, Xinyi, Zhu, Qian, Denbeigh, Janet M, Remmes, Nicholas B, Herman, Michael G, Beltran, Chris J, Yuan, Jian, Greipp, Patricia T, Boughey, Judy C, Wang, Liewei, Johnson, Neil, Goetz, Matthew P, Sarkaria, Jann N, Lou, Zhenkun, Mutter, Robert W

“…Proton Bragg peak irradiation has a higher ionizing density than conventional photon irradiation or the entrance of the proton beam profile. Whether targeting…”
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Characterizing Proton-Induced Biological Effects in a Mouse Spinal Cord Model: A Comparison of Bragg Peak and Entrance Beam Response in Single and Fractionated Exposures by Denbeigh, Janet M., Howard, Michelle E., Garcia, Darwin A., Debrot, Emily K., Cole, Kristin C., Remmes, Nicholas B., Beltran, Chris J.

“…Proton relative biological effectiveness (RBE) is a dynamic variable influenced by factors like linear energy transfer (LET), dose, tissue type, and biological…”
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In vivo assessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction: an animal study by Soreide, Endre, Denbeigh, Janet M, Lewallen, Eric A, Thaler, Roman, Xu, Wei, Berglund, Lawrence, Yao, Jie J, Martinez, Anthony, Nordsletten, Lars, van Wijnen, Andre J, Kakar, Sanjeev

“…AimsOptions for the treatment of intra-articular ligament injuries are limited, and insufficient ligament reconstruction can cause painful joint instability,…”
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Inflammatory Markers Involved in the Pathogenesis of Dupuytren's Contracture by Cates, William T, Denbeigh, Janet M, Salvagno, Ralph T, Kakar, Sanjeev, van Wijnen, Andre J, Eaton, Charles

“…Dupuytren's disease is a common fibroproliferative disease that can result in debilitating hand deformities. Partial correction and return of deformity are…”
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Surface Roughness of Titanium Orthopedic Implants Alters the Biological Phenotype of Human Mesenchymal Stromal Cells by Lewallen, Eric A, Trousdale, William H, Thaler, Roman, Yao, Jie J, Xu, Wei, Denbeigh, Janet M, Nair, Asha, Kocher, Jean-Pierre, Dudakovic, Amel, Berry, Daniel J, Cohen, Robert C, Abdel, Matthew P, Lewallen, David G, van Wijnen, Andre J

“…Metal orthopedic implants are largely biocompatible and generally achieve long-term structural fixation. However, some orthopedic implants may loosen over time…”
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Dosimetric Assessment of a High Precision System for Mouse Proton Irradiation to Assess Spinal Cord Toxicity by Howard, Michelle E., Denbeigh, Janet M., Debrot, Emily K., Garcia, Darwin A., Remmes, Nicholas B., Herman, Michael G., Beltran, Chris J.

“…The uncertainty associated with the relative biological effectiveness (RBE) in proton therapy, particularly near the Bragg peak (BP), has led to the shift…”
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BMP2 and GDF5 for Compartmentalized Regeneration of the Scapholunate Ligament by Lui, Hayman, Vaquette, Cedryck, Denbeigh, Janet M, Bindra, Randy, van Wijnen, Andre J, Kakar, Sanjeev

“…Chronic injuries to the scapholunate ligament (SLIL) alter carpal kinematics and may progress to early degenerative osteoarthritis. To date, there is no…”
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Modernizing Storage Conditions for Fresh Osteochondral Allografts by Optimizing Viability at Physiologic Temperatures and Conditions by Denbeigh, Janet M., Hevesi, Mario, Paggi, Carlo A., Resch, Zachary T., Bagheri, Leila, Mara, Kristin, Arani, Arvin, Zhang, Chenghao, Larson, A. Noelle, Saris, Daniel B.F., Krych, Aaron J., van Wijnen, Andre J.

“…Objective. Osteochondral allograft (OCA) transplantation has demonstrated good long-term outcomes in treatment of cartilage defects. Viability, a key factor in…”
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Fresh Osteochondral Allograft Transplantation in the Knee: A Viability and Histologic Analysis for Optimizing Graft Viability and Expanding Existing Standard Processed Graft Resources Using a Living Donor Cartilage Program by Hevesi, Mario, Denbeigh, Janet M., Paggi, Carlo A., Galeano-Garces, Catalina, Bagheri, Leila, Larson, A. Noelle, Stuart, Michael J., Saris, Daniel B. F., van Wijnen, Andre J., Krych, Aaron J.

“…Objective This study aims to (1) determine and validate living cartilage allograft transplantation as a novel source for viable osteochondral allograft (OCA)…”
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Effect of Lidocaine on Viability and Gene Expression of Human Adipose–derived Mesenchymal Stem Cells: An in vitro Study by Nie, Hai, Kubrova, Eva, Wu, Tao, Denbeigh, Janet M., Hunt, Christine, Dietz, Allan B., Smith, Jay, Qu, Wenchun, Wijnen, Andre J.

“…Objective To assess the biologic effects of lidocaine on the viability, proliferation, and function of human adipose tissue–derived mesenchymal stromal/stem…”
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Safety Studies for Use of Adipose Tissue‐Derived Mesenchymal Stromal/Stem Cells in a Rabbit Model for Osteoarthritis to Support a Phase I Clinical Trial by Riester, Scott M., Denbeigh, Janet M., Lin, Yang, Jones, Dakota L., de Mooij, Tristan, Lewallen, Eric A., Nie, Hai, Paradise, Christopher R., Radel, Darcie J., Dudakovic, Amel, Camilleri, Emily T., Larson, Dirk R., Qu, Wenchun, Krych, Aaron J., Frick, Matthew A., Im, Hee‐Jeong, Dietz, Allan B., Smith, Jay, van Wijnen, Andre J.

“…Adipose‐derived mesenchymal stem cells (AMSCs) offer potential as a therapeutic option for clinical applications in musculoskeletal regenerative medicine…”
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