Search Results - "Denardo, David"

Macrophages as regulators of tumour immunity and immunotherapy by DeNardo, David G., Ruffell, Brian

“…Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This…”
Get full text

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy by Jiang, Hong, Hegde, Samarth, DeNardo, David G.

“…Tumor-associated fibrosis is characterized by unchecked pro-fibrotic and pro-inflammatory signaling. The components of fibrosis including significant numbers…”
Get full text

A framework for advancing our understanding of cancer-associated fibroblasts by Sahai, Erik, Astsaturov, Igor, Cukierman, Edna, DeNardo, David G., Egeblad, Mikala, Evans, Ronald M., Fearon, Douglas, Greten, Florian R., Hingorani, Sunil R., Hunter, Tony, Hynes, Richard O., Jain, Rakesh K., Janowitz, Tobias, Jorgensen, Claus, Kimmelman, Alec C., Kolonin, Mikhail G., Maki, Robert G., Powers, R. Scott, Puré, Ellen, Ramirez, Daniel C., Scherz-Shouval, Ruth, Sherman, Mara H., Stewart, Sheila, Tlsty, Thea D., Tuveson, David A., Watt, Fiona M., Weaver, Valerie, Weeraratna, Ashani T., Werb, Zena

“…Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling,…”
Get full text

Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression by DeNardo, David G, Coussens, Lisa M

“…Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial…”
Get full text

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy by Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G

“…DeNardo and colleagues report that inhibiting focal adhesion kinase in pancreatic ductal adenocarcinoma (PDAC) in mice reduces fibrosis and improves the…”
Get full text

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer by Hegde, Samarth, Krisnawan, Varintra E., Herzog, Brett H., Zuo, Chong, Breden, Marcus A., Knolhoff, Brett L., Hogg, Graham D., Tang, Jack P., Baer, John M., Mpoy, Cedric, Lee, Kyung Bae, Alexander, Katherine A., Rogers, Buck E., Murphy, Kenneth M., Hawkins, William G., Fields, Ryan C., DeSelm, Carl J., Schwarz, Julie K., DeNardo, David G.

“…Here, we utilized spontaneous models of pancreatic and lung cancer to examine how neoantigenicity shapes tumor immunity and progression. As expected,…”
Get full text

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity by DeNardo, David G., Andreu, Pauline, Coussens, Lisa M.

“…Tumor-associated myeloid cells have been implicated in regulating many of the “hallmarks of cancer” and thus fostering solid tumor development and metastasis…”
Get full text

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial by Nywening, Timothy M, MD, Wang-Gillam, Andrea, MD, Sanford, Dominic E, MD, Belt, Brian A, MA, Panni, Roheena Z, MD, Cusworth, Brian M, BA, Toriola, Adetunji T, MD, Nieman, Rebecca K, MS, Worley, Lori A, BS, Yano, Motoyo, MD, Fowler, Kathryn J, MD, Lockhart, A Craig, MD, Suresh, Rama, MD, Tan, Benjamin R, MD, Lim, Kian-Huat, MD, Fields, Ryan C, MD, Strasberg, Steven M, Prof, Hawkins, William G, Prof, DeNardo, David G, PhD, Goedegebuure, S Peter, PhD, Linehan, David C, Dr Prof

“…Summary Background In pancreatic ductal adenocarcinoma, the CCL2–CCR2 chemokine axis is used to recruit tumour-associated macrophages for construction of an…”
Get full text

Targeting dendritic cells to drive PDAC immunotherapy response by Weinstein, Alyssa G., DeNardo, David G.

“…Pancreatic adenocarcinoma (PDAC) has been historically unresponsive to immunotherapy, predominantly due to lower antigen loads and a lack of tumor-infiltrating…”
Get full text

CD4 + T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages by DeNardo, David G., Barreto, Jairo B., Andreu, Pauline, Vasquez, Lesley, Tawfik, David, Kolhatkar, Nikita, Coussens, Lisa M.

“…During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of…”
Get full text

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis by Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.

“…Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To…”
Get full text

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models by Zhu, Yu, Knolhoff, Brett L, Meyer, Melissa A, Nywening, Timothy M, West, Brian L, Luo, Jingqin, Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C, DeNardo, David G

“…Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor…”
Get full text

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression by Zhu, Yu, Herndon, John M., Sojka, Dorothy K., Kim, Ki-Wook, Knolhoff, Brett L., Zuo, Chong, Cullinan, Darren R., Luo, Jingqin, Bearden, Audrey R., Lavine, Kory J., Yokoyama, Wayne M., Hawkins, William G., Fields, Ryan C., Randolph, Gwendalyn J., DeNardo, David G.

“…Tumor-associated macrophages (TAMs) are essential components of the cancer microenvironment and play critical roles in the regulation of tumor progression…”
Get full text

Rethinking immune checkpoint blockade: ‘Beyond the T cell’ by Liu, Xiuting, Hogg, Graham D, DeNardo, David G

“…The clinical success of immune checkpoint inhibitors has highlighted the central role of the immune system in cancer control. Immune checkpoint inhibitors can…”
Get full text

Pancreatic Cancer's PD1-Roadblock: When T-Cell Reinvigoration Is Not Enough by Lander, Varintra E, DeNardo, David G

“…PD1-blockade combinations in pancreatic ductal adenocarcinoma have been poorly effective, and the underlying reasons for this are unknown. A recent study…”
Get full text

Targeting both tumour-associated CXCR2 + neutrophils and CCR2 + macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma by Nywening, Timothy M, Belt, Brian A, Cullinan, Darren R, Panni, Roheena Z, Han, Booyeon J, Sanford, Dominic E, Jacobs, Ryan C, Ye, Jian, Patel, Ankit A, Gillanders, William E, Fields, Ryan C, DeNardo, David G, Hawkins, William G, Goedegebuure, Peter, Linehan, David C

“…Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to facilitate myeloid cell recruitment from the bone marrow to establish an…”
Get more information

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses by MITCHEM, Jonathan B, BRENNAN, Donal J, HEWITT, Stephen, MALLYA UDUPI, Girish, GALLAGHER, William M, WEGNER, Craig, WEST, Brian L, WANG-GILLAM, Andrea, GOEDEGEBUURE, Peter, LINEHAN, David C, DENARDO, David G, KNOLHOFF, Brett L, BELT, Brian A, YU ZHU, SANFORD, Dominic E, BELAYGOROD, Larisa, CARPENTER, Danielle, COLLINS, Lynne, PIWNICA-WORMS, David

“…Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in aggressive tumors. Consequently, the type and quality of immune responses…”
Get full text

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance by Meyer, Melissa A., Baer, John M., Knolhoff, Brett L., Nywening, Timothy M., Panni, Roheena Z., Su, Xinming, Weilbaecher, Katherine N., Hawkins, William G., Ma, Cynthia, Fields, Ryan C., Linehan, David C., Challen, Grant A., Faccio, Roberta, Aft, Rebecca L., DeNardo, David G.

“…Tumors employ multiple mechanisms to evade immune surveillance. One mechanism is tumor-induced myelopoiesis, whereby the expansion of immunosuppressive myeloid…”
Get full text

Immune cells as mediators of solid tumor metastasis by DeNardo, David G., Johansson, Magnus, Coussens, Lisa M.

“…Outgrowths of disseminated metastases remain the primary cause of mortality in cancer patients; however, molecular and cellular mechanisms regulating…”
Get full text

Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner by Volk-Draper, Lisa, Hall, Kelly, Griggs, Caitlin, Rajput, Sandeep, Kohio, Pascaline, DeNardo, David, Ran, Sophia

“…Emerging evidence suggests that cytotoxic therapy may actually promote drug resistance and metastasis while inhibiting the growth of primary tumors. Work in…”
Get full text