Search Results - "Denard, Carl A"

Improving and repurposing biocatalysts via directed evolution by Denard, Carl A, Ren, Hengqian, Zhao, Huimin

“…•Directed evolution has become a proven method to engineer biocatalysts’ overall performance.•New library creation and screening approaches are at the base of…”
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Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis by Denard, Carl A, Hartwig, John F, Zhao, Huimin

“…In a continuous effort to emulate the efficiency of biosynthetic pathways, considerable progress has been made in developing one-pot chemoenzymatic processes…”
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Modular assembly of designer PUF proteins for specific post-transcriptional regulation of endogenous RNA by Abil, Zhanar, Denard, Carl A, Zhao, Huimin

“…Due to their modular repeat structure, Pumilio/fem-3 mRNA binding factor (PUF) proteins are promising candidates for designer RNA-binding protein (RBP)…”
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Leveraging yeast sequestration to study and engineer posttranslational modification enzymes by Martinusen, Samantha G., Denard, Carl A.

“…Enzymes that catalyze posttranslational modifications (PTMs) of peptides and proteins (PTM–enzymes)—proteases, protein ligases, oxidoreductases, kinases, and…”
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Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme by Denard, Carl A., Huang, Hua, Bartlett, Mark J., Lu, Lu, Tan, Yichen, Zhao, Huimin, Hartwig, John F.

“…Although chemical and enzymatic catalysts have been combined, reactions in which an organometallic catalyst and a metalloenzyme work cooperatively to create…”
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Development of a One-Pot Tandem Reaction Combining Ruthenium-Catalyzed Alkene Metathesis and Enantioselective Enzymatic Oxidation To Produce Aryl Epoxides by Denard, Carl A, Bartlett, Mark J, Wang, Yajie, Lu, Lu, Hartwig, John F, Zhao, Huimin

“…We report the development of a tandem chemoenzymatic transformation that combines alkene metathesis with enzymatic epoxidation to provide aryl epoxides. The…”
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Combining Rh-Catalyzed Diazocoupling and Enzymatic Reduction To Efficiently Synthesize Enantioenriched 2‑Substituted Succinate Derivatives by Wang, Yajie, Bartlett, Mark J, Denard, Carl A, Hartwig, John F, Zhao, Huimin

“…We report the development of a modular, one-pot, sequential chemoenzymatic system for the formal enantioselective construction of the C–C bond in 2-aryl…”
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Tandem Catalytic Conversion of Glucose to 5‑Hydroxymethylfurfural with an Immobilized Enzyme and a Solid Acid by Huang, Hua, Denard, Carl A, Alamillo, Ricardo, Crisci, Anthony J, Miao, Yurun, Dumesic, James. A, Scott, Susannah L, Zhao, Huimin

“…Conversion of cellulosic biomass to renewable chemicals such as 5-hydroxymethylfurfural (HMF) is of high current interest. Herein, we report a rare example of…”
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YESS 2.0, a Tunable Platform for Enzyme Evolution, Yields Highly Active TEV Protease Variants by Denard, Carl A, Paresi, Chelsea, Yaghi, Rasha, McGinnis, Natalie, Bennett, Zachary, Yi, Li, Georgiou, George, Iverson, Brent L

“…Here we describe YESS 2.0, a highly versatile version of the yeast endoplasmic sequestration screening (YESS) system suitable for engineering and…”
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Modular and integrative activity reporters enhance biochemical studies in the yeast ER by Martinusen, Samantha G, Slaton, Ethan W, Nelson, Sage E, Pulgar, Marian A, Besu, Julia T, Simas, Cassidy F, Denard, Carl A

“…Abstract The yeast endoplasmic reticulum sequestration and screening (YESS) system is a broadly applicable platform to perform high-throughput biochemical…”
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Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme by Denard, Carl A., Huang, Hua, Bartlett, Mark J., Lu, Lu, Tan, Yichen, Zhao, Huimin, Hartwig, John F.

“…Although chemical and enzymatic catalysts have been combined, reactions in which an organometallic catalyst and a metalloenzyme work cooperatively to create…”
Get full text