Severe anemia, anorexia, and uremia associated with diabetic foot infections: A case series

Anemia of inflammation, as found in many chronic disease states, is common among persons with diabetic foot infections but is typically mild and self-limited. Herein we present four cases of patients with foot infections accompanied by severe anemia (nadir hemoglobin <8 gm/dL and resulting in tra...

Full description

Saved in:

Bibliographic Details
Published in:	Foot (Edinburgh, Scotland) Vol. 53; p. 101926
Main Authors:	Den, Jennifer L., Gay, Lindsey M., Barshes, Neal R.
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01-12-2022
Subjects:	Anemia - etiology Blood Transfusion Diabetes Mellitus Diabetic Foot - complications Diabetic Foot - diagnosis Diabetic Foot - therapy Diabetic foot infection Humans Inflammation Sepsis Sepsis Inflammation Diabetic foot infection
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Anemia of inflammation, as found in many chronic disease states, is common among persons with diabetic foot infections but is typically mild and self-limited. Herein we present four cases of patients with foot infections accompanied by severe anemia (nadir hemoglobin <8 gm/dL and resulting in transfusion of 4 + units of blood) as well as significant weight loss (30 + pounds), hyponatremia (<135 mmol/L), hypoalbuminemia (nadir <2 gm/dL), uremia and other metabolic derangements •The effect of diabetic foot infections on whole body metabolism has not been well described.•Anemia of inflammation is typically mild and self-limited.•Severe anemia (Hgb <8 gm/dL) and weight loss (30–60 lb) can be seen in foot infections.•Foot infections can be accompanied by 10 + metabolic derangements.•These striking patterns may suggest an unusual and undescribed syndrome.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0958-2592 1532-2963
DOI:	10.1016/j.foot.2022.101926