Search Results - "Demuth, HU"

The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals Its Functional Regulation and Enzymatic Mechanism by Engel, Michael, Hoffmann, Torsten, Wagner, Leona, Wermann, Michael, Heiser, Ulrich, Kiefersauer, Reiner, Huber, Robert, Bode, Wolfram, Demuth, Hans-Ulrich, Brandstetter, Hans

“…The membrane-bound glycoprotein dipeptidyl peptidase IV (DP IV, CD26) is a unique multifunctional protein, acting as receptor, binding and proteolytic…”
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Type 2 diabetes—Therapy with dipeptidyl peptidase IV inhibitors by Demuth, Hans-Ulrich, McIntosh, Christopher H.S., Pederson, Raymond A.

“…The sole application of an inhibitor of the dipeptidyl peptidase DP IV (also DP 4, CD26, DPP-IV or DPP-4) to a mammal subsequently leading to improved glucose…”
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Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY‐cleaving peptidases and potential drug interactions in CNS and Periphery by Wagner, Leona, Wolf, Raik, Zeitschel, Ulrike, Rossner, Steffen, Petersén, Åsa, Leavitt, Blair R., Kästner, Florian, Rothermundt, Matthias, Gärtner, Ulf‐Torsten, Gündel, Daniel, Schlenzig, Dagmar, Frerker, Nadine, Schade, Jutta, Manhart, Susanne, Rahfeld, Jens‐Ulrich, Demuth, Hans‐Ulrich, Hörsten, Stephan

“…The bioactivity of neuropeptide Y (NPY) is either N‐terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)‐like enzymes or…”
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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions by Schilling, Stephan, Hoffmann, Torsten, Manhart, Susanne, Hoffmann, Matthias, Demuth, Hans-Ulrich

“…N-terminal pyroglutamate (pGlu) formation from glutaminyl precursors is a posttranslational event in the processing of bioactive neuropeptides such as…”
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Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats by POSPISILIK, J. Andrew, MARTIN, Jennifer, DOTY, Timothy, EHSES, Jan A, PAMIR, Nathalie, LYNN, Francis C, PITEAU, Shalea, DEMUTH, Hans-Ulrich, MCINTOSH, Christopher H. S, PEDERSON, Raymond A

“…Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats J. Andrew Pospisilik 1 ,…”
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Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents? by McIntosh, Christopher H.S., Demuth, Hans-Ulrich, Pospisilik, J.Andrew, Pederson, Raymond

“…A number of new approaches to diabetes therapy are currently undergoing clinical trials, including those involving stimulation of the pancreatic β-cell with…”
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Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery by Cynis, Holger, Rahfeld, Jens-Ulrich, Stephan, Anett, Kehlen, Astrid, Koch, Birgit, Wermann, Michael, Demuth, Hans-Ulrich, Schilling, Stephan

“…Mammalian glutaminyl cyclase isoenzymes (isoQCs) were identified. The analysis of the primary structure of human isoQC (h-isoQC) revealed conservation of the…”
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Glucose-Dependent Insulinotropic Polypeptide Promotes β-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase by Ehses, Jan A, Casilla, Vanbric R, Doty, Tim, Pospisilik, J. Andrew, Winter, Kyle D, Demuth, Hans-Ulrich, Pederson, Raymond A, McIntosh, Christopher H. S

“…The incretin glucose-dependent insulinotropic polypeptide (GIP) is a major regulator of postprandial insulin secretion in mammals. Recent studies in our…”
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The First Potent Inhibitors for Human Glutaminyl Cyclase:  Synthesis and Structure−Activity Relationship by Buchholz, Mirko, Heiser, Ulrich, Schilling, Stephan, Niestroj, André J, Zunkel, Katrin, Demuth, Hans-Ulrich

“…The first effective inhibitors for human glutaminyl cyclase (QC) are described. The structures are developed by applying a ligand-based optimization approach…”
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Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms by Tan-No, K, Taira, A, Inoue, M, Ohshima, K, Sakurada, T, Sakurada, C, Nylander, I, Demuth, H.-U, Silberring, J, Terenius, L, Tadano, T, Kisara, K

“…The antinociceptive effect of intrathecally (i.t.) administered protease inhibitors was tested against capsaicin (800 ng) injected into the dorsal surface of a…”
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Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats by POSPISILIK, J. A, STAFFORD, S. G, DEMUTH, H.-U, BROWNSEY, R, PARKHOUSE, W, FINEGOOD, D. T, MCINTOSH, C. H. S, PEDERSON, R. A

“…Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity,…”
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Rigidity and Flexibility of Dipeptidyl Peptidase IV: Crystal Structures of and Docking Experiments with DPIV by Engel, Michael, Hoffmann, Torsten, Manhart, Susanne, Heiser, Ulrich, Chambre, Sylvie, Huber, Robert, Demuth, Hans-Ulrich, Bode, Wolfram

“…Dipeptidyl peptidase IV (DPIV) is an α,β-hydrolase-like serine exopeptidase, which removes dipeptides, preferentially with a C-terminal l-Pro residue, from the…”
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Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion by Schulz, Ingo, Zeitschel, Ulrike, Rudolph, Thomas, Ruiz‐Carrillo, David, Rahfeld, Jens‐Ulrich, Gerhartz, Bernd, Bigl, Volker, Demuth, Hans‐Ulrich, Roßner, Steffen

“…For a long time, prolyl endopeptidase (PEP) was believed to inactivate neuropeptides in the extracellular space. However, reports on the intracellular activity…”
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Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF zucker rat: A euglycemic-hyperinsulinemic clamp study by POSPISILIK, John A, STAFFORD, Sara G, DEMUTH, Hans-Ulrich, MCINTOSH, Christopher H. S, PEDERSON, Raymond A

“…Upon release into circulation, the potent insulin secretagogues glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are…”
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Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells by Girardi, Adriana C C, Knauf, Felix, Demuth, Hans-Ulrich, Aronson, Peter S

“…We recently reported that NHE3 exists in multimeric complexes with dipeptidyl peptidase IV (DPPIV) in renal brush-border membranes. To examine the possible…”
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Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide by R A Pederson, H A White, D Schlenzig, R P Pauly, C H McIntosh, H U Demuth

“…Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. R A Pederson , H A…”
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Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators by Schilling, Stephan, Niestroj, André J, Rahfeld, Jens-Ulrich, Hoffmann, Torsten, Wermann, Michael, Zunkel, Katrin, Wasternack, Claus, Demuth, Hans-Ulrich

“…Human glutaminyl cyclase (QC) was identified as a metalloenzyme as suggested by the time-dependent inhibition by the heterocyclic chelators 1,10-phenanthroline…”
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Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide by Hinke, SA, Pauly, RP, Ehses, J, Kerridge, P, Demuth, HU, McIntosh, CH, Pederson, RA

“…It is well documented that the release of insulin from isolated perifused islets attenuates over time, despite a continued glucose stimulation. In the current…”
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Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus by McIntosh, Christopher H.S., Demuth, Hans-Ulrich, Kim, Su-Jin, Pospisilik, J. Andrew, Pederson, Raymond A.

“…A number of alternative therapies for type 2 diabetes are currently under development that take advantage of the actions of the incretin hormones glucagon-like…”
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Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease by Rossner, Steffen, Schulz, Ingo, Zeitschel, Ulrike, Schliebs, Reinhard, Bigl, Volker, Demuth, Hans-Ulrich

“…Prolyl endopeptidase (PEP) is believed to inactivate neuropeptides that are present in the extracellular space. However, the intracellular localization of PEP…”
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