Search Results - "Dempster, D.W."

Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism by Dempster, D.W, Müller, R, Zhou, H, Kohler, T, Shane, E, Parisien, M, Silverberg, S.J, Bilezikian, J.P

“…Abstract By conventional 2-dimensional, histomorphometric analysis, we and others have previously shown that cancellous bone architecture is preserved in mild…”
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Bone microarchitecture and the effects of bisphosphonate therapy by Dempster, D.W

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Subtle changes in bone mineralization density distribution in most severely affected patients with chronic obstructive pulmonary disease by Misof, B.M, Roschger, P, Jorgetti, V, Klaushofer, K, Borba, V.Z.C, Boguszewski, C.L, Cohen, A, Shane, E, Zhou, H, Dempster, D.W, Moreira, C.A

“…Abstract Chronic obstructive pulmonary disease (COPD) is associated with low aBMD as measured by DXA and altered microstructure as assessed by bone…”
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Constant mineralization density distribution in cancellous human bone by Roschger, P, Gupta, H.S, Berzlanovich, A, Ittner, G, Dempster, D.W, Fratzl, P, Cosman, F, Parisien, M, Lindsay, R, Nieves, J.W, Klaushofer, K

“…The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of…”
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Effects of ibandronate on bone quality: Preclinical studies by Bauss, F, Dempster, D.W

“…Abstract Osteoporosis is a skeletal disorder characterized by low bone mass and deterioration of bone microarchitecture resulting in bone fragility, which…”
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Anabolic action of parathyroid hormone on cortical and cancellous bone differs between axial and appendicular skeletal sites in mice by Zhou, H, Iida-Klein, A, Lu, S.S, Ducayen-Knowles, M, Levine, L.R, Dempster, D.W, Lindsay, R

“…The mouse is being increasingly used to study the anabolic action of parathyroid hormone (PTH) on the skeleton. The efficacy of intermittent PTH treatment on…”
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Differential effects on bone quality indices in hypoparathyroidism by Paschalis, E.P, Roschger, P, Zoehrer, R, Misof, B, Rubin, M.R, Dempster, D.W, Sliney, J, Compito, C, Zhou, H, Silverberg, S.J, Bilezikian, J.P, Klaushofer, K

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Temporal changes in cancellous bone structure of rats immediately after ovariectomy by Dempster, D.W., Birchman, R., Xu, R., Lindsay, R., Shen, V.

“…To understand the structural changes accompanying estrogen deficiency-induced bone loss, we examined the temporal changes in cancellous bone structure in an…”
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Temporal expression of the anabolic action of PTH in cancellous bone of ovariectomized rats by Meng, X.W., Liang, X.G., Birchman, R., Wu, D.D., Dempster, D.W., Lindsay, R., Shen, V.

“…When administered intermittently, parathyroid hormone (PTH) is a potent anabolic agent in both human and animal bone. To improve our understanding of this…”
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10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension by Bone, Henry G, Prof, Wagman, Rachel B, MD, Brandi, Maria L, Prof, Brown, Jacques P, MD, Chapurlat, Roland, Prof, Cummings, Steven R, Prof, Czerwiński, Edward, Prof, Fahrleitner-Pammer, Astrid, MD, Kendler, David L, Prof, Lippuner, Kurt, MD, Reginster, Jean-Yves, Prof, Roux, Christian, Prof, Malouf, Jorge, MD, Bradley, Michelle N, PhD, Daizadeh, Nadia S, PhD, Wang, Andrea, MA, Dakin, Paula, MBChB, Pannacciulli, Nicola, MD, Dempster, David W, Prof, Papapoulos, Socrates, Prof

“…Summary Background Long-term safety and efficacy of osteoporosis treatment are important because of the chronic nature of the disease. We aimed to assess the…”
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Short-term changes in histomorphometric and biochemical turnover markers and bone mineral density in estrogen- and/or dietary calcium-deficient rats by Shen, V., Birchman, R., Xu, R., Lindsay, R., Dempster, D.W.

“…Both estrogen and dietary calcium deficiencies are important risk factors in the pathogenesis of osteoporosis. We used an animal model of postmenopausal…”
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Short term immobilization-induced cancellous bone loss is limited to regions undergoing high turnover and/or modeling in mature rats by Shen, V., Liang, X.G., Birchman, R., Wu, D.D., Healy, D., Lindsay, R., Dempster, D.W.

“…Estrogen and calcium deficiencies increase both bone resorption and formation, whereas immobilization mainly decreases bone formation. How these functionally…”
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In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1 by Goetz, T.G., Nair, N., Shiau, S., Recker, R.R., Lappe, J.M., Dempster, D.W., Zhou, H., Zhao, B., Guo, X., Shen, W., Nickolas, T.L., Kamanda-Kosseh, M., Bucovsky, M., Stubby, J., Shane, E., Cohen, A.

“…Summary We examined serum IGF-1 in premenopausal IOP, finding relationships that were opposite to those expected: higher IGF-1 was associated with lower bone…”
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Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy by Cohen, A., Dempster, D. W., Müller, R., Guo, X. E., Nickolas, T. L., Liu, X. S., Zhang, X. H., Wirth, A. J., van Lenthe, G. H., Kohler, T., McMahon, D. J., Zhou, H., Rubin, M. R., Bilezikian, J. P., Lappe, J. M., Recker, R. R., Shane, E.

“…Summary We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT)…”
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Lack of changes in histomorphometric, bone mass, and biochemical parameters in ovariohysterectomized dogs by Shen, V, Dempster, D W, Birchman, R, Mellish, R W, Church, E, Kohn, D, Lindsay, R

“…A predictable animal model with skeletal remodeling characteristics similar to those of humans is needed to facilitate the understanding of the mechanism of…”
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Effects of endogenous and exogenous parathyroid hormone (PTH) on the human skeleton by Dempster, D.W.

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Effet du denosumab (DMAb) sur la minéralisation de la matrice osseuse : résultats de l’étude de phase 3 FREEDOM by Boivin, G., Brown, J., Yue, S., Farlay, D., Rizzo, S., Song, J., Wang, A., Wagman, R., Dempster, D.W.

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Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones by Xia, L, Kilb, J, Wex, H, Li, Z, Lipyansky, A, Breuil, V, Stein, L, Palmer, J T, Dempster, D W, Brömme, D

“…We have localized cathepsin K in rat osteoclasts and within exposed resorption pits by immuno-fluorescence microscopy. Intracellular staining using an antibody…”
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Urinary hydroxypyridinium crosslinks of collagen as markers of bone resorption and estrogen efficacy in postmenopausal osteoporosis by Seibel, M.J., Cosman, F., Shen, V., Gordon, S., Dempster, D.W., Ratcliffe, A., Lindsay, R.

“…Estrogen deficiency‐induced bone loss has been associated with accelerated bone turnover. Levels of some biochemical markers, such as serum osteocalcin (BGP),…”
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Underutilization of aspirin in hemodialysis patients for primary and secondary prevention of cardiovascular disease by Dempster, D W, Rosenstock, J L, Schwimmer, J A, Panagopoulos, G, DeVita, M V, Michelis, M F

“…Patients on hemodialysis are at high risk for cardiovascular disease (CVD). Aspirin is an established therapy for primary and secondary prevention of CVD that…”
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