Search Results - "Dempcy, Robert"

One- and Two-Metal Ion Catalysis of the Hydrolysis of Adenosine 3‘-Alkyl Phosphate Esters. Models for One- and Two-Metal Ion Catalysis of RNA Hydrolysis by Bruice, Thomas C, Tsubouchi, Akira, Dempcy, Robert O, Olson, Leif P

“…Adenosine 3‘-O(PO2 -)OCH2R phosphate esters have been synthesized with R = 8-hydroxyquinol-2-yl (1a) and 8-(hydroxyquinolyl)-2-methylene (1b). The adenosine…”
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Synthesis of the Polycation Thymidyl DNG, Its Fidelity in Binding Polyanionic DNA/RNA, and the Stability and Nature of the Hybrid Complexes by Dempcy, Robert O, Browne, Kenneth A, Bruice, Thomas C

“…Putative drugs consisting of oligonucleotide analogs capable of combining with RNA or DNA, thereby arresting cellular processes at the translational or…”
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Single nucleotide polymorphism genotyping by two colour melting curve analysis using the MGB Eclipse Probe System in challenging sequence environment by Belousov, Yevgeniy S, Welch, Robert A, Sanders, Silvia, Mills, Alan, Kulchenko, Alena, Dempcy, Robert, Afonina, Irina A, Walburger, David K, Glaser, Cynthia L, Yadavalli, Sunita, Vermeulen, Nicolaas M J, Mahoney, Walt

“…Probe and primer design for single nucleotide polymorphism (SNP) detection can be very challenging for A-T DNA-rich targets, requiring long sequences with…”
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Association of Short-Strand DNA Oligomers with Guanidinium-Linked Nucleosides. A Kinetic and Thermodynamic Study by Blaskó, Andrei, Dempcy, Robert O, Minyat, Elvira E, Bruice, Thomas C

“…Complementary short-strand DNA homooligomers and guanidinium-linked homonucleosides associate and form triplexes in solution. The melting temperatures, T m,…”
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Synthesis of a Thymidyl Pentamer of Deoxyribonucleic Guanidine and Binding Studies with DNA Homopolynucleotides by Dempcy, Robert O., Browne, Kenneth A., Bruce, Thomas C.

“…Replacement of the phosphodiester linkages of the polyanion DNA with guanidine linkers provides the polycation deoxynucleic guanidine (DNG). The synthesis of…”
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The Negative Charge of Alkyl Phosphate Diesters and The Slow-Gaited Hydrolysis of RNA and DNA. Catalysis of RNA Hydrolysis through Metal Ion Ligation to the Ester >PO2- Moiety by Dempcy, Robert O, Bruice, Thomas C

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Design and Synthesis of Deoxynucleic Guanidine: A Polycation Analogue of DNA by Dempcy, Robert O., Almarsson, Örn, Bruice, Thomas C.

“…The basic strategy is described for the connection of nucleosides by guanidinium (g) linkers to provide the positively charged deoxynucleic guanidine putative…”
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Design and Synthesis of Ribonucleic Guanidine: A Polycationic Analog of RNA by Dempcy, Robert O., Luo, Jia, Bruice, Thomas C.

“…Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine…”
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Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase by Dempcy, Robert O, Skibo, Edward B

“…Described herein is the rational design of irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase (PNPase). Inhibitor design started with…”
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Binding Studies of Cationic Thymidyl Deoxyribonucleic Guanidine to RNA Homopolynucleotides by Browne, Kenneth A., Dempcy, Robert O., Bruice, Thomas C.

“…Deoxyribonucleic guanidine is a potential antisense agent that is generated via the replacement of the negative phosphodiester linkages of DNA [--0--(PO-…”
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Linkers designed to intercalate the double helix greatly facilitate DNA alkylation by triplex-forming oligonucleotides carrying a cyclopropapyrroloindole reactive moiety by Dempcy, Robert O., Kutyavin, Igor V., Mills, Alan G., Lukhtanov, Eugeny A., Meyer, Rich B.

“…Triplex-forming oligonucleotides (TFOs) bind sequence-specifically in the major groove of double-stranded DNA. Cyclopropapyrroloindole (CPI), the electrophilic…”
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Fidelity of Binding of the Guanidinium Nucleic Acid (DNG) d(Tg)4-T-azido with Short Strand DNA Oligomers (A5G3A5, GA4G3A4G, G2A3G3A3G2, G2A2G5A2G2). A Kinetic and Thermodynamic Study by Blaskó, Andrei, Minyat, Elvira E, Dempcy, Robert O, Bruice, Thomas C

“…Short strand DNA oligomers (A5G3A5, GA4G3A4G, G2A3G3A3G2, and G2A2G5A2G2) and the guanidinium (g) linked thymidyl nucleoside d(Tg)4-T-azido associate as…”
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Synthesis, characterization, and application of substituted pyrazolopyrimidine nucleosides by Dempcy, Robert O, Podyminogin, Mikhail A, Reed, Michael W

“…This unit describes, in detail, the preparation of 3-aminopropyl-substituted pyrazolo[3,4-d]pyrimidine analogs of the purines deoxyadenosine (dA) and…”
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3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures by Kutyavin, I V, Afonina, I A, Mills, A, Gorn, V V, Lukhtanov, E A, Belousov, E S, Singer, M J, Walburger, D K, Lokhov, S G, Gall, A A, Dempcy, R, Reed, M W, Meyer, R B, Hedgpeth, J

“…DNA probes with conjugated minor groove binder (MGB) groups form extremely stable duplexes with single-stranded DNA targets, allowing shorter probes to be used…”
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Regioselective synthesis of imidazo[4,5-g]quinazoline quinone nucleosides and quinazoline amino nucleosides. Studies of their xanthine oxidase and purine nucleoside phosphorylase substrate activity by Dempcy, Robert O'Hara, Skibo, Edward B

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3'-Minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures by Kutyavin, I. V.

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Reduced aggregation and improved specificity of G‐rich oligodeoxyribonucleotides containing pyrazolo[3,4‐d]pyrimidine guanine bases by Kutyavin, Igor V., Lokhov, Sergey G., Afonina, Irina A., Dempcy, Robert, Gall, Alexander A., Gorn, Vladimir V., Lukhtanov, Eugene, Metcalf, Mark, Mills, Alan, Reed, Michael W., Sanders, Sylvia, Shishkina, Irina, Vermeulen, Nicolaas M. J.

“…Guanine (G)‐rich oligodeoxyribonucleotides (ODNs) can form undesired complexes by self association through non‐Watson–Crick interactions. These aggregates can…”
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Rational design of reductive alkylating agents directed toward purine nucleoside phosphorylase and inosine 5'-monophosphate dehydrogenase by Dempcy, Robert O

“…The synthesis of novel reductive alkylating agents based on the quinazoline and imidazo (4,5-g) quinazoline ring systems was carried out in conjunction with…”
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Reduced aggregation and improved specificity of G-rich oligodeoxyribonucleotides containing pyrazolo3,4-dpyrimidine guanine bases by Kutyavin, Igor V, Lokhov, Sergey G, Afonina, Irina A, Dempcy, Robert, Gall, Alexander A, Gorn, Vladimir V, Lukhtanov, Eugene, Metcalf, Mark, Mills, Alan, Reed, Michael W, Sanders, Sylvia, Shishkina, Irina, Vermeulen, Nicolaas M J

“…Guanine (G)-rich oligodeoxyribonucleotides (ODNs) can form undesired complexes by self association through non-Watson-Crick interactions. These aggregates can…”
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Kinetic studies of 2-(2'-Haloethyl) and 2-ethenyl substituted quinazolinone alkylating agents. Acid-catalyzed dehydrohalogenation and alkylation involving a quinazolinone prototropic tautomer by Dempcy, R O, Skibo, E B

“…The mechanism of halide elimination from 2-haloethyl-5,8-dihydroxyquinazolin-4(3H)-ones was studied in aqueous buffer by means of a pH-rate profile, buffer…”
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