Search Results - "Demosky, Stephen J"

High‐density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation by Thacker, Seth G., Zarzour, Abdalrahman, Chen, Ye, Alcicek, Mustafa S., Freeman, Lita A., Sviridov, Dennis O., Demosky, Stephen J., Remaley, Alan T.

“…Summary Interleukin‐1β (IL‐1β), a potent pro‐inflammatory cytokine, has been implicated in many diseases, including atherosclerosis. Activation of IL‐1β is…”
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Lipoprotein X Causes Renal Disease in LCAT Deficiency by Ossoli, Alice, Neufeld, Edward B, Thacker, Seth G, Vaisman, Boris, Pryor, Milton, Freeman, Lita A, Brantner, Christine A, Baranova, Irina, Francone, Nicolás O, Demosky, Jr, Stephen J, Vitali, Cecilia, Locatelli, Monica, Abbate, Mauro, Zoja, Carlamaria, Franceschini, Guido, Calabresi, Laura, Remaley, Alan T

“…Human familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized by low HDL, accumulation of an abnormal cholesterol-rich…”
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Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis[S] by Vaisman, Boris L., Demosky, Stephen J., Stonik, John A., Ghias, Mona, Knapper, Cathy L., Sampson, Maureen L., Dai, Cuilian, Levine, Stewart J., Remaley, Alan T.

“…The role of endothelial ABCA1 expression in reverse cholesterol transport (RCT) was examined in transgenic mice, using the endothelial-specific Tie2 promoter…”
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Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31 by Freeman, Lita A, Demosky, Jr, Stephen J, Konaklieva, Monika, Kuskovsky, Rostislav, Aponte, Angel, Ossoli, Alice F, Gordon, Scott M, Koby, Ross F, Manthei, Kelly A, Shen, Min, Vaisman, Boris L, Shamburek, Robert D, Jadhav, Ajit, Calabresi, Laura, Gucek, Marjan, Tesmer, John J G, Levine, Rodney L, Remaley, Alan T

“…Lecithin:cholesterol acyltransferase (LCAT) catalyzes plasma cholesteryl ester formation and is defective in familial lecithin:cholesterol acyltransferase…”
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Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice by Bocharov, Alexander V., Eggerman, Thomas L., Patterson, Amy P., Remaley, Alan T., Sampson, Maureen L., Stonik, John A., Liu, Chengyu, Demosky, Stephen J., Amar, Marcelo J., Freeman, Lita A., Vishnyakova, Tatyana G., Vaisman, Boris L., Pryor, Milton

“…The role of scavenger receptor class B, type I (SR-BI) in endothelial cells (EC) was examined in several novel transgenic mouse models expressing SR-BI in…”
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The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease by Neufeld, Edward B, Stonik, John A, Demosky, Jr, Stephen J, Knapper, Catherine L, Combs, Christian A, Cooney, Adele, Comly, Marcella, Dwyer, Nancy, Blanchette-Mackie, Joan, Remaley, Alan T, Santamarina-Fojo, Silvia, Brewer, Jr, H Bryan

“…We have previously established that the ABCA1 transporter, which plays a critical role in the lipidation of extracellular apolipoprotein acceptors, traffics…”
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Immunoassay Interference by a Commonly Used Blood Collection Tube Additive, the Organosilicone Surfactant Silwet L-720 by Bowen, Raffick A.R, Chan, Yung, Ruddel, Mark E, Hortin, Glen L, Csako, Gyorgy, Demosky, Stephen J., Jr, Remaley, Alan T

“…A small number of immunoassays on several different types of analyzers were recently adversely affected by tube additives in Becton Dickinson (BD) Vacutainer…”
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LCAT Modulates Atherogenic Plasma Lipoproteins and the Extent of Atherosclerosis Only in the Presence of Normal LDL Receptors in Transgenic Rabbits by Brousseau, Margaret E, Kauffman, Richard D, Herderick, Edward E, Demosky, Stephen J, Evans, Wende, Marcovina, Santica, Santamarina-Fojo, Silvia, Brewer, H Bryan, Hoeg, Jeffrey M

“…ABSTRACTElevated low density lipoprotein cholesterol (LDL-C) and reduced high density lipoprotein cholesterol (HDL-C) concentrations are independent risk…”
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Cellular Localization and Trafficking of the Human ABCA1 Transporter by Neufeld, E B, Remaley, A T, Demosky, S J, Stonik, J A, Cooney, A M, Comly, M, Dwyer, N K, Zhang, M, Blanchette-Mackie, J, Santamarina-Fojo, S, Brewer, Jr, H B

“…ABCA1, the ATP-binding cassette protein mutated in Tangier disease, mediates the efflux of excess cellular sterol to apoA-I and thereby the formation of high…”
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The ABCA1 Transporter Modulates Late Endocytic Trafficking by Neufeld, Edward B., Stonik, John A., Demosky, Stephen J., Knapper, Catherine L., Combs, Christian A., Cooney, Adele, Comly, Marcella, Dwyer, Nancy, Blanchette-Mackie, Joan, Remaley, Alan T., Santamarina-Fojo, Silvia, Brewer, H. Bryan

“…We have previously established that the ABCA1 transporter, which plays a critical role in the lipidation of extracellular apolipoprotein acceptors, traffics…”
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Lecithin:Cholesterol Acyltransferase Overexpression Generates Hyperalpha-lipoproteinemia and a Nonatherogenic Lipoprotein Pattern in Transgenic Rabbits (∗) by Hoeg, Jeffrey M., Vaisman, Boris L., Demosky, Stephen J., Meyn, Susan M., Talley, Glenda D., Hoyt, Robert F., Feldman, Sanford, Bérard, Annie M., Sakai, Nao, Wood, Douglas, Brousseau, Margaret E., Marcovina, Santica, Brewer, H. Bryan, Santamarina-Fojo, Silvia

“…Cholesterol esterification within plasma lipoprotein particles is catalyzed by lecithin:cholesterol acyltransferase (LCAT). The impact of the overexpression of…”
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Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase by Brousseau, M E, Wang, J, Demosky, Jr, S J, Vaisman, B L, Talley, G D, Santamarina-Fojo, S, Brewer, Jr, H B, Hoeg, J M

“…Familial hypercholesterolemia (FH), a disease caused by a variety of mutations in the low density lipoprotein receptor (LDLr) gene, leads not only to elevated…”
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Distinct Hepatic Receptors for Low Density Lipoprotein and Apolipoprotein E in Humans by Hoeg, Jeffrey M., Demosky, Stephen J., Gregg, Richard E., Schaefer, Ernst J., Brewer, H. Bryan

“…Since the liver is a central organ for lipid and lipoprotein synthesis and catabolism, hepatic receptors for specific apolipoproteins on plasma lipoproteins…”
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Low-density lipoprotein receptor and apolipoprotein A-I and B expression in human enterocytes by Sviridov, Dmitri, Hoeg, Jeffrey M, Eggerman, Thomas, Demosky, Stephen J, Safonova, Irina G, Brewer, H Bryan

“…Low-density lipoprotein receptor (LDL-R) was found to be expressed in human small intestine epithelial cells, enterocytes. The relative abundance of LDL-R mRNA…”
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Abstract 556: Lipoprotein Remodeling and Cholesterol Exchange Monitored Using Fluorescent Lipids and Proteins by Neufeld, Edward B, Francone, Nicolas O, Yilmaz, Gizem, Gordon, Scott M, Sviridov, Denis O, Sampson, Maureen, Demosky, Stephen J, Pryor, Milton, Amar, Marcelo J, Remaley, Alan T

“…Abstract only We developed a sensitive and robust in vitro method to monitor lipoprotein cholesterol and protein exchange and lipoprotein remodeling, using…”
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Abstract 226: Mechanism of LCAT Activation by Compound A by Freeman, Lita A, Demosky, Stephen J, Konaklieva, Monika, Kuskovsky, Rostislav, Gordon, Scott M, Ossoli, Alice F, Vaisman, Boris L, Shamburek, Robert D, Aponte, Angel, Gucek, Marjan, Tesmer, John J, Levine, Rodney L, Remaley, Alan T

“…Abstract only Background: Lecithin:cholesterol acyltransferase (LCAT) catalyzes cholesteryl ester (CE) production from free cholesterol (FC) and…”
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Abstract 230: Lipoprotein X Causes Renal Disease in LCAT Deficiency by Neufeld, Edward B, Ossoli, Alice, Thacker, Seth G, Vaisman, Boris, Pryor, Milton, Freeman, Lita A, Brantner, Christine A, Baranova, Irina, Francone, Nicolás O, Demosky, Stephen J, Vitali, Cecilia, Locatelli, Monica, Abbate, Mauro, Zoja, Carlamaria, Franceschini, Guido, Axley, Milton J, Karathanasis, Sotirios K, Calabresi, Laura, Remaley, Alan T

“…Abstract only Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized by low HDL, accumulation of an abnormal cholesterol-rich…”
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Abstract 5481: Expression of Human ABCA1 in Endothelium Protects Against Diet-Induced Atherosclerosis in Mice by Vaisman, Boris L, Knapper, Catherine L, Demosky, Stephen J, Stonik, John A, Amar, Marcelo J, Remaley, Alan T

“…Abstract only Cholesterol homeostasis in endothelium plays significant role in protecting against development of atherosclerosis and in supporting normal…”
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Abstract 3636: The Effects of Arginase II Overexpression on Endothelial Function in Transgenic Mouse Model by Vaisman, Boris L, Wood, Katherine C, Demosky, Stephen J, Knapper, Catherine L, Chin-Dusting, Jaye, Morris, Sidney M, Gladwin, Mark T, Remaley, Alan T

“…Abstract only Endothelium is a major regulator of local vascular homeostasis. Its normal function is crucial for prevention of the development of…”
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Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis by Hoeg, J.M. (National Institutes of Health, Bethesda, MD.), Santamarina-Fojo, S, Berard, A.M, Cornhill, J.F, Herderick, E.E, Feldmand, S.H, Haudenschild, C.C, Vaisman, B.L, Hoyt, R.F. Jr, Demosky, S.J. Jr

“…Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. Transgenic rabbits…”
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