Search Results - "Demogines, Ann"

Dual host-virus arms races shape an essential housekeeping protein by Demogines, Ann, Abraham, Jonathan, Choe, Hyeryun, Farzan, Michael, Sawyer, Sara L

“…Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also…”
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Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats by DEMOGINES, Ann, FARZAN, Michael, SAWYER, Sara L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats by Ng, Melinda, Ndungo, Esther, Kaczmarek, Maria E, Herbert, Andrew S, Binger, Tabea, Kuehne, Ana I, Jangra, Rohit K, Hawkins, John A, Gifford, Robert J, Biswas, Rohan, Demogines, Ann, James, Rebekah M, Yu, Meng, Brummelkamp, Thijn R, Drosten, Christian, Wang, Lin-Fa, Kuhn, Jens H, Müller, Marcel A, Dye, John M, Sawyer, Sara L, Chandran, Kartik

“…Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse…”
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Rapid evolution of BRCA1 and BRCA2 in humans and other primates by Lou, Dianne I, McBee, Ross M, Le, Uyen Q, Stone, Anne C, Wilkerson, Gregory K, Demogines, Ann M, Sawyer, Sara L

“…The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA…”
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Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs by Kaelber, Jason T, Demogines, Ann, Harbison, Carole E, Allison, Andrew B, Goodman, Laura B, Ortega, Alicia N, Sawyer, Sara L, Parrish, Colin R

“…Parvoviruses exploit transferrin receptor type-1 (TfR) for cellular entry in carnivores, and specific interactions are key to control of host range. We show…”
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Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast by Demogines, Ann, Smith, Erin, Kruglyak, Leonid, Alani, Eric

“…Complex traits typically involve the contribution of multiple gene variants. In this study, we took advantage of a high-density genotyping analysis of the BY…”
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Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins by Peng, Lisheng, Adler, Michael, Demogines, Ann, Borrell, Andrew, Liu, Huisheng, Tao, Liang, Tepp, William H, Zhang, Su-Chun, Johnson, Eric A, Sawyer, Sara L, Dong, Min

“…Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies…”
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Incompatibilities involving yeast mismatch repair genes: a role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates by Demogines, Ann, Wong, Alex, Aquadro, Charles, Alani, Eric

“…Genetic background effects underlie the penetrance of most genetically determined phenotypes, including human diseases. To explore how such effects can modify…”
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Ancient and recent adaptive evolution of primate non-homologous end joining genes by Demogines, Ann, East, Alysia M, Lee, Ji-Hoon, Grossman, Sharon R, Sabeti, Pardis C, Paull, Tanya T, Sawyer, Sara L

“…In human cells, DNA double-strand breaks are repaired primarily by the non-homologous end joining (NHEJ) pathway. Given their critical nature, we expected NHEJ…”
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A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction by Nepveu-Traversy, Marie-Édith, Demogines, Ann, Fricke, Thomas, Plourde, Mélodie B., Riopel, Kathleen, Veillette, Maxime, Diaz-Griffero, Felipe, Sawyer, Sara L., Berthoux, Lionel

“…TRIM5α from the rhesus macaque (TRIM5αRh) is a restriction factor that shows strong activity against HIV-1. TRIM5αRh binds specifically to HIV-1 capsid (CA)…”
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Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses by Kerr, Scott A, Jackson, Eleisha L, Lungu, Oana I, Meyer, Austin G, Demogines, Ann, Ellington, Andrew D, Georgiou, George, Wilke, Claus O, Sawyer, Sara L

“…Animal viruses frequently cause zoonotic disease in humans. As these viruses are highly diverse, evaluating the threat that they pose remains a major…”
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Species-Specific Features of DARC, the Primate Receptor for Plasmodium vivax and Plasmodium knowlesi by Demogines, Ann, Truong, Kimberly A., Sawyer, Sara L.

“…The DARC (Duffy antigen/receptor for chemokines) gene, also called Duffy or FY, encodes a membrane-bound chemokine receptor. Two malaria parasites, Plasmodium…”
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Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein: e1001571 by Demogines, Ann, Abraham, Jonathan, Choe, Hyeryun, Farzan, Michael, Sawyer, Sara L

“…Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also…”
Get full text

Vibrio cholerae Detection by the FilmArray® Gastrointestinal (GI) Panel by Clarke, Kimon, Ton, Han, Bridon, Isabelle, Rogatcheva, Margarita, Demogines, Ann, Henderson, Dave, Saif, Dana, Kanack, Kristen

“…Abstract Background The purpose of this study was to investigate reported false positive FilmArray GI Panel detections of V. cholerae in clinical patient…”
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Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach by Zanders, Sarah, Ma, Xin, Roychoudhury, Arindam, Hernandez, Ryan D, Demogines, Ann, Barker, Brandon, Gu, Zhenglong, Bustamante, Carlos D, Alani, Eric

“…DNA replication errors that escape polymerase proofreading and mismatch repair (MMR) can lead to base substitution and frameshift mutations. Such mutations can…”
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Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins: e1004177 by Peng, Lisheng, Adler, Michael, Demogines, Ann, Borrell, Andrew, Liu, Huisheng, Tao, Liang, Tepp, William H, Zhang, Su-Chun, Johnson, Eric A, Sawyer, Sara L, Dong, Min

“…Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies…”
Get full text

157. Variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins by Peng, Lisheng, Adler, Michael, Demogines, Ann, Borrell, Andrew, Liu, Huisheng, Tao, Liang, Tepp, William H., Zhang, Su-Chun, Johnson, Eric A., Sawyer, Sara L., Dong, Min

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Rapid evolution of BRCA1 and BRCA2in humans and other primates by Lou, Dianne I, McBee, Ross M, Le, Uyen Q, Stone, Anne C, Wilkerson, Gregory K, Demogines, Ann M, Sawyer, Sara L

“…The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA…”
Get full text

Identification and Dissection of a Complex DNA Repair Sensitivity Phenotype in Baker's Yeast: e1000123 by Demogines, Ann, Smith, Erin, Kruglyak, Leonid, Alani, Eric

“…Complex traits typically involve the contribution of multiple gene variants. In this study, we took advantage of a high-density genotyping analysis of the BY…”
Get full text

Evolutionary reconstructions of the transferrin receptor of caniforms supports canine parvovirus being a reemerged and not a novel pathogen in dogs by Kaelber, Jason T, Demogines, Ann, Harbison, Carole E, Allison, Andrew B, Goodman, Laura B, Ortega, Alicia N, Sawyer, Sara L, Parrish, Colin R

“…Parvoviruses exploit transferrin receptor type-1 (TfR) for cellular entry in carnivores, and specific interactions are key to control of host range. We show…”
Get full text