Search Results - "Demmers, Jeroen A. A."

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways by Blokhuis, Anna M., Koppers, Max, Groen, Ewout J. N., van den Heuvel, Dianne M. A., Dini Modigliani, Stefano, Anink, Jasper J., Fumoto, Katsumi, van Diggelen, Femke, Snelting, Anne, Sodaar, Peter, Verheijen, Bert M., Demmers, Jeroen A. A., Veldink, Jan H., Aronica, Eleonora, Bozzoni, Irene, den Hertog, Jeroen, van den Berg, Leonard H., Pasterkamp, R. Jeroen

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS…”
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Return to quiescence of mouse neural stem cells by degradation of a proactivation protein by Urbán, Noelia, van den Berg, Debbie L. C., Forget, Antoine, Andersen, Jimena, Demmers, Jeroen A. A., Hunt, Charles, Ayrault, Olivier, Guillemot, François

“…Quiescence is essential for long-term maintenance of adult stem cells. Niche signals regulate the transit of stem cells from dormant to activated states. Here,…”
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Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens by Bezstarosti, Karel, Lamers, Mart M, Doff, Wouter A. S, Wever, Peter C, Thai, Khoa T. D, van Kampen, Jeroen J. A, Haagmans, Bart L, Demmers, Jeroen A. A

“…The rapid, sensitive and specific detection of SARS-CoV-2 is critical in responding to the current COVID-19 outbreak. In this proof-of-concept study, we…”
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Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination by Davó-Martínez, Carlota, Helfricht, Angela, Ribeiro-Silva, Cristina, Raams, Anja, Tresini, Maria, Uruci, Sidrit, van Cappellen, Wiggert A, Taneja, Nitika, Demmers, Jeroen A A, Pines, Alex, Theil, Arjan F, Vermeulen, Wim, Lans, Hannes

“…Abstract The SWI/SNF family of ATP-dependent chromatin remodeling complexes is implicated in multiple DNA damage response mechanisms and frequently mutated in…”
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VEGFR2 translocates to the nucleus to regulate its own transcription by Domingues, Inês, Rino, José, Demmers, Jeroen A A, de Lanerolle, Primal, Santos, Susana Constantino Rosa

“…Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) is the major mediator of the angiogenic effects of VEGF. In addition to its well known role as a…”
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The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing by Goulielmaki, Evi, Tsekrekou, Maria, Batsiotos, Nikos, Ascensão Ferreira, Mariana, Ledaki, Eleftheria, Stratigi, Kalliopi, Chatzinikolaou, Georgia, Topalis, Pantelis, Kosteas, Theodore, Altmüller, Janine, Demmers, Jeroen A., BARBOSA MORAIS, NUNO LUÍS, Garinis, George A.

“…© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair by Schwertman, Petra, Lagarou, Anna, Dekkers, Dick H W, Raams, Anja, van der Hoek, Adriana C, Laffeber, Charlie, Hoeijmakers, Jan H J, Demmers, Jeroen A A, Fousteri, Maria, Vermeulen, Wim, Marteijn, Jurgen A

“…Jurgen Marteijn, Wim Vermeulen and colleagues report proteomic identification of UVSSA in a UV-induced protein complex implicated in UV-sensitive syndrome…”
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The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics by Llerena Schiffmacher, Diana A., Lee, Shun-Hsiao, Kliza, Katarzyna W., Theil, Arjan F., Akita, Masaki, Helfricht, Angela, Bezstarosti, Karel, Gonzalo-Hansen, Camila, van Attikum, Haico, Verlaan-de Vries, Matty, Vertegaal, Alfred C. O., Hoeijmakers, Jan H. J., Marteijn, Jurgen A., Lans, Hannes, Demmers, Jeroen A. A., Vermeulen, Michiel, Sixma, Titia K., Ogi, Tomoo, Vermeulen, Wim, Pines, Alex

“…Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of…”
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Combgap contributes to recruitment of Polycomb group proteins in Drosophila by Ray, Payal, De, Sandip, Mitra, Apratim, Bezstarosti, Karel, Demmers, Jeroen A. A., Pfeifer, Karl, Kassis, Judith A.

“…Polycomb group (PcG) proteins are responsible for maintaining the silenced transcriptional state of many developmentally regulated genes. PcG proteins are…”
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Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation by van Sluis, Marjolein, Yu, Qing, van der Woude, Melanie, Gonzalo-Hansen, Camila, Dealy, Shannon C., Janssens, Roel C., Somsen, Hedda B., Ramadhin, Anisha R., Dekkers, Dick H. W., Wienecke, Hannah Lena, Demmers, Joris J. P. G., Raams, Anja, Davó-Martínez, Carlota, Llerena Schiffmacher, Diana A., van Toorn, Marvin, Häckes, David, Thijssen, Karen L., Zhou, Di, Lammers, Judith G., Pines, Alex, Vermeulen, Wim, Pothof, Joris, Demmers, Jeroen A. A., van den Berg, Debbie L. C., Lans, Hannes, Marteijn, Jurgen A.

“…DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede…”
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Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation by van der Pluijm, Ingrid, Burger, Joyce, van Heijningen, Paula M, IJpma, Arne, van Vliet, Nicole, Milanese, Chiara, Schoonderwoerd, Kees, Sluiter, Willem, Ringuette, Lea-Jeanne, Dekkers, Dirk H W, Que, Ivo, Kaijzel, Erik L, te Riet, Luuk, MacFarlane, Elena G, Das, Devashish, van der Linden, Reinier, Vermeij, Marcel, Demmers, Jeroen A, Mastroberardino, Pier G, Davis, Elaine C, Yanagisawa, Hiromi, Dietz, Harry C, Kanaar, Roland, Essers, Jeroen

“…Abstract Aim Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To discover novel robust biomarkers, we aimed to better…”
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC by Raj, V. Stalin, Mou, Huihui, Smits, Saskia L., Dekkers, Dick H. W., Müller, Marcel A., Dijkman, Ronald, Muth, Doreen, Demmers, Jeroen A. A., Zaki, Ali, Fouchier, Ron A. M., Thiel, Volker, Drosten, Christian, Rottier, Peter J. M., Osterhaus, Albert D. M. E., Bosch, Berend Jan, Haagmans, Bart L.

“…Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the…”
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Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth by Morhayim, Jess, Peppel, Jeroen, Demmers, Jeroen A. A., Kocer, Gulistan, Nigg, Alex L., Driel, Marjolein, Chiba, Hideki, Leeuwen, Johannes P.

“…Beyond forming bone, osteoblasts play pivotal roles in various biologic processes, including hematopoiesis and bone metastasis. Extracellular vesicles (EVs)…”
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Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease by Salih, Mahdi, Demmers, Jeroen A, Bezstarosti, Karel, Leonhard, Wouter N, Losekoot, Monique, van Kooten, Cees, Gansevoort, Ron T, Peters, Dorien J M, Zietse, Robert, Hoorn, Ewout J

“…Novel therapies in autosomal dominant polycystic kidney disease (ADPKD) signal the need for markers of disease progression or response to therapy. This study…”
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Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells by Ramakrishnaiah, Vedashree, Thumann, Christine, Fofana, Isabel, Habersetzer, Francois, Pan, Qiuwei, de Ruiter, Petra E., Willemsen, Rob, Demmers, Jeroen A. A., Raj, Victor Stalin, Jenster, Guido, Kwekkeboom, Jaap, Tilanus, Hugo W., Haagmans, Bart L., Baumert, Thomas F., van der Laan, Luc J. W.

“…Recent evidence indicates there is a role for small membrane vesicles, including exosomes, as vehicles for intercellular communication. Exosomes secreted by…”
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Distinct proteomic profiles in prefrontal subareas of elderly major depressive disorder and bipolar disorder patients by Qi, Yang-Jian, Lu, Yun-Rong, Shi, Li-Gen, Demmers, Jeroen A. A., Bezstarosti, Karel, Rijkers, Erikjan, Balesar, Rawien, Swaab, Dick, Bao, Ai-Min

“…We investigated for the first time the proteomic profiles both in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) of major…”
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CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment by Smits, Daphne J., Dekker, Jordy, Schot, Rachel, Tabarki, Brahim, Alhashem, Amal, Demmers, Jeroen A. A., Dekkers, Dick H. W., Romito, Antonio, van der Spek, Peter J., van Ham, Tjakko J., Bertoli-Avella, Aida M., Mancini, Grazia M. S.

“…CLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and reportedly…”
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Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function by Avagliano Trezza, Rossella, Punt, A. Mattijs, Mientjes, Edwin, van den Berg, Marlene, Zampeta, F. Isabella, de Graaf, Ilona J., van der Weegen, Yana, Demmers, Jeroen A. A., Elgersma, Ype, Distel, Ben

“…Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by brain-specific loss of UBE3A, an E3 ubiquitin protein ligase. A substantial number of…”
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Proteomic analysis of the microenvironment of developing oocytes by Twigt, John, Steegers-Theunissen, Regine P., Bezstarosti, Karel, Demmers, Jeroen A. A.

“…We utilized a setup based on extensive pre‐fractionation of proteolytic peptides and nanoflow reversed‐phase LC‐MS/MS to identify the (sub)proteome of human…”
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Dynamic Assembly of End-Joining Complexes Requires Interaction between Ku70/80 and XRCC4 by Mari, Pierre-Olivier, Florea, Bogdan I., Persengiev, Stephan P., Verkaik, Nicole S., Brüggenwirth, Hennie T., Modesti, Mauro, Giglia-Mari, Giuseppina, Bezstarosti, Karel, Demmers, Jeroen A. A., Luider, Theo M., Houtsmuller, Adriaan B., van Gent, Dik C.

“…DNA double-strand break (DSB) repair by nonhomologous end joining (NHEJ) requires the assembly of several proteins on DNA ends. Although biochemical studies…”
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