Search Results - "Demitri, M T"
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alpha-MSH and its receptors in regulation of tumor necrosis factor-alpha production by human monocyte/macrophages
Published in The American journal of physiology (01-05-1999)“…The hypothesis that macrophages contain an autocrine circuit based on melanocortin [ACTH and alpha-melanocyte-stimulating hormone (alpha-MSH)] peptides has…”
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Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia
Published in Journal of leukocyte biology (01-06-1998)“…Inflammatory processes contribute to neurodegenerative disease, stroke, encephalitis, and other central nervous system (CNS) disorders. Activated microglia are…”
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Differential effect of glucocorticoids on tumour necrosis factor production in mice: up‐regulation by early pretreatment with dexamethasone
Published in Clinical and experimental immunology (01-04-1994)“…SUMMARY Glucocorticoids (GC) are well known inhibitors of tumour necrosis factor (TNF) production. We investigated the role of endogenous GC in the regulation…”
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Ciliary neurotrophic factor inhibits brain and peripheral tumor necrosis factor production and, when coadministered with its soluble receptor, protects mice from lipopolysaccharide toxicity
Published in Molecular medicine (Cambridge, Mass.) (01-07-1995)“…The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such…”
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Chlorpromazine inhibits tumour necrosis factor synthesis and cytotoxicity in vitro
Published in Immunology (01-11-1995)“…Chlorpromazine (CPZ) has been previously shown to protect against endotoxin [lipopolysaccharide (LPS)] lethality and inhibit the release of tumour necrosis…”
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Protective effect of chlorpromazine on TNF-mediated hapten-induced irritant reaction
Published in European cytokine network (Montrouge) (01-01-1995)“…Picryl chloride-induced irritant reaction (IR) was shown to be mediated by tumor necrosis factor (TNF). Anti-TNF monoclonal antibodies, but not interleukin 1…”
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Plasma concentrations of α‐melanocyte‐stimulating hormone are elevated in patients on chronic haemodialysis
Published in Nephrology, dialysis, transplantation (01-08-2000)“…Background. Clinical and/or laboratory signs of systemic inflammation occur frequently in patients undergoing long‐term haemodialysis. It is likely, therefore,…”
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Role of xanthine oxidase and reactive oxygen intermediates in LPS- and TNF-induced pulmonary edema
Published in The Journal of laboratory and clinical medicine (01-03-1994)“…We studied the role of reactive oxygen intermediates (ROI) in lipopolysaccharide (LPS)-induced pulmonary edema. LPS treatment (600 micrograms/mouse, IP) was…”
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Inhibition of systemic inflammation by central action of the neuropeptide alpha-melanocyte- stimulating hormone
Published in Neuroimmunomodulation (01-05-1999)“…The neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) reduces fever and acute inflammation in the skin when administered centrally. The aim of the…”
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Effects of methyl palmitate on cytokine release, liver injury and survival in mice with sepsis
Published in European cytokine network (Montrouge) (01-12-1996)“…The effects of methyl palmitate (MP), a known inhibitor of Kupffer cells, were studied in a model of polymicrobial sepsis induced in CD-1 mice by cecal…”
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Protective effect of ciliary neurotrophic factor (CNTF) in a model of endotoxic shock: action mechanisms and role of CNTF receptor alpha
Published in Journal of inflammation (1998)“…Ciliary neurotrophic factor (CNTF) inhibits the production of tumor necrosis factor (TNF) in lipopolysaccharide (LPS)-treated mice and protects against LPS…”
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Mechanisms of interleukin-2-induced hydrothoraxy in mice: protective effect of endotoxin tolerance and dexamethasone and possible role of reactive oxygen intermediates
Published in Journal of immunotherapy with emphasis on tumor immunology (01-04-1994)“…Interleukin (IL)-2 is known to induce vascular leak syndrome (VLS), which was suggested to be mediated by immune system-derived cytokines, including tumor…”
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α-MSH in Systemic Inflammation: Central and Peripheral Actions
Published in Annals of the New York Academy of Sciences (01-10-1999)“…Until recently, inflammation was believed to arise from events taking place exclusively in the periphery. However, it is now clear that central neurogenic…”
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