Search Results - "Deminoff, Stephen J."

Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy by Stephan, Joseph S, Yeh, Yuh-Ying, Ramachandran, Vidhya, Deminoff, Stephen J, Herman, Paul K

“…Macroautophagy (or autophagy) is a conserved degradative pathway that has been implicated in a number of biological processes, including organismal aging,…”
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A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing by Mousley, Carl J., Yuan, Peihua, Gaur, Naseem A., Trettin, Kyle D., Nile, Aaron H., Deminoff, Stephen J., Dewar, Brian J., Wolpert, Max, Macdonald, Jeffrey M., Herman, Paul K., Hinnebusch, Alan G., Bankaitis, Vytas A.

“…Kes1, and other oxysterol-binding protein superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal…”
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An Evolutionary Proteomics Approach Identifies Substrates of the cAMP-Dependent Protein Kinase by Budovskaya, Yelena V., Stephan, Joseph S., Deminoff, Stephen J., Herman, Paul K., Pawson, Anthony J.

“…Protein kinases are important mediators of much of the signal transduction that occurs in eukaryotic cells. Unfortunately, the identification of protein kinase…”
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Distal Recognition Sites in Substrates Are Required for Efficient Phosphorylation by the cAMP-Dependent Protein Kinase by Deminoff, Stephen J, Ramachandran, Vidhya, Herman, Paul K

“…Protein kinases are important mediators of signal transduction in eukaryotic cells, and identifying the substrates of these enzymes is essential for a complete…”
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Reverse Recruitment: The Nup84 Nuclear Pore Subcomplex Mediates Rap1/Gcr1/Gcr2 Transcriptional Activation by Menon, Balaraj B., Sarma, Nayan J., Pasula, Satish, Deminoff, Stephen J., Willis, Kristine A., Barbara, Kellie E., Andrews, Brenda, Santangelo, George M., Levine, Michael S.

“…The recruitment model for gene activation presumes that DNA is a platform on which the requisite components of the transcriptional machinery are assembled. In…”
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The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy in Saccharomyces cerevisiae by Stephan, Joseph S., Yeh, Yuh-Ying, Vidhya Ramachandran, Vidhya, Deminoff, Stephen J., Herman, Paul K.

“…Macroautophagy (hereafter autophagy) is a conserved membrane trafficking pathway responsible for the turnover of cytosolic protein and organelles during…”
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Using Substrate-Binding Variants of the cAMP-Dependent Protein Kinase to Identify Novel Targets and a Kinase Domain Important for Substrate Interactions in Saccharomyces cerevisiae by Deminoff, Stephen J, Howard, Susie C, Hester, Arelis, Warner, Sarah, Herman, Paul K

“…Protein kinases mediate much of the signal transduction in eukaryotic cells and defects in kinase function are associated with a variety of human diseases. To…”
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Identifying Atg1 Substrates: Four Means to an End by Deminoff, Stephen J., Herman, Paul K.

“…Autophagy is essential for normal development and the response to a variety of stress conditions, including nutrient deprivation. The Atg1…”
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Rap1p requires Gcr1p and Gcr2p homodimers to activate ribosomal protein and glycolytic genes, respectively by Deminoff, S J, Santangelo, G M

“…Efficient transcription of ribosomal protein (RP) and glycolytic genes requires the Rap1p/Gcr1p regulatory complex. A third factor, Gcr2p, is required for only…”
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Specialized Rap1p/Gcr1p Transcriptional Activation Through Gcr1p DNA Contacts Requires Gcr2p, as Does Hyperphosphorylation of Gcr1p by Zeng, X, Deminoff, S. J, Santangelo, G. M

“…The multifunctional regulatory factor Rap1p of Saccharomyces cerevisiae accomplishes one of its tasks, transcriptional activation, by complexing with Gcr1p. An…”
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Coiled coil structures and transcription: an analysis of the S. cerevisiae coilome by Barbara, Kellie E, Willis, Kristine A, Haley, Terry M, Deminoff, Stephen J, Santangelo, George M

“…The α-helical coiled coil is a simple but widespread motif that is an integral feature of many cellular structures. Coiled coils allow monomeric building…”
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Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae by Howard, S.C, Deminoff, S.J, Herman, P.K

“…The Ras proteins regulate many aspects of cell growth in the budding yeast, Saccharomyces cerevisiae, via the cAMP-dependent protein kinase (PKA). Here, we…”
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Using substrate‐binding variants of the cAMP‐dependent protein kinase (PKA) to identify docking sites within two physiological target proteins by Deminoff, Stephen J., Ramachandran, Vidhya, Herman, Paul K.

“…Cells use complex signaling networks to bring about the appropriate responses to stimuli and defects in these signaling pathways contribute to cancer and other…”
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An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinas by Budovskaya, Yelena V, Stephan, Joseph S, Deminoff, Stephen J, Herman, Paul K

“…Protein kinases are important mediators of much of the signal transduction that occurs in eukaryotic cells. Unfortunately, the identification of protein kinase…”
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Reverse recruitment: The Nup84 nuclear pore subcomplex mediates Rap1/Gcr/Gcr2 transcriptional activation by Menon, Barlaraj B, Sarma, Nayan J, Pasula, Satish, Deminoff, Stephen J

“…The recruitment model for gene activation presumes that DNA is a platform on which the requisite components of the transcriptional machinery are assembled. In…”
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Unigenic Evolution: A Novel Genetic Method Localizes a Putative Leucine Zipper That Mediates Dimerization of the Saccharomyces cerevisiae Regulator Gcr1p by Deminoff, S. J, Tornow, J, Santangelo, G. M

“…The GCR1 gene of Saccharomyces cerevisiae encodes a transcriptional activator that complexes with Rap1p and, through UASRPG elements (Rap1p DNA binding sites),…”
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