Search Results - "Demidov, Vadim V"

Ab initio RNA folding by discrete molecular dynamics: from structure prediction to folding mechanisms by Ding, Feng, Sharma, Shantanu, Chalasani, Poornima, Demidov, Vadim V, Broude, Natalia E, Dokholyan, Nikolay V

“…RNA molecules with novel functions have revived interest in the accurate prediction of RNA three-dimensional (3D) structure and folding dynamics. However,…”
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Rolling-circle amplification in DNA diagnostics: the power of simplicity by Demidov, Vadim V

“…Due to its robustness and simplicity, the rolling replication of circular DNA probes holds a distinct position in DNA diagnostics among other isothermal…”
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A Novel Rolling Circle Amplification-Based Detection of SARS-CoV-2 with Multi-Region Padlock Hybridization by Kumari, Rajesh, Lim, Ji Won, Sullivan, Matthew Ryan, Malampy, Rachel, Baush, Connor, Smolina, Irina, Robin, Howard, Demidov, Vadim V, Ugolini, Giovanni Stefano, Auclair, Jared R, Konry, Tania

“…SARS-CoV-2 has remained a global health burden, primarily due to the continuous evolution of different mutant strains. These mutations present challenges to…”
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Two sides of the coin: affinity and specificity of nucleic acid interactions by Demidov, Vadim V, Frank-Kamenetskii, Maxim D

“…During the past decade, synthetic nucleobase oligomers have found wide use in biochemical sciences, biotechnology and molecular medicine, both as research…”
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Site-specifically deuterated essential lipids as new drugs against neuronal, retinal and vascular degeneration by Demidov, Vadim V.

“…•Damage of nerve cellular membranes by reactive oxygen species (ROS) is thought to be the principal cause of various neurological diseases, with some of them…”
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Hybridization of DNA and PNA Molecular Beacons to Single-Stranded and Double-Stranded DNA Targets by Kuhn, Heiko, Demidov, Vadim V., Coull, James M., Fiandaca, Mark J., Gildea, Brian D., Frank-Kamenetskii, Maxim D.

“…Molecular beacons are sensitive fluorescent probes hybridizing selectively to designated DNA and RNA targets. They have recently become practical tools for…”
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Fast Complementation of Split Fluorescent Protein Triggered by DNA Hybridization by Demidov, Vadim V., Dokholyan, Nikolay V., Witte-Hoffmann, Carlos, Chalasani, Poornima, Yiu, Hung-Wei, Ding, Feng, Yu, Yong, Cantor, Charles R., Broude, Natalia E.

“…Fluorescent proteins have proven to be excellent reporters and biochemical sensors with a wide range of applications. In a split form, they are not…”
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RNA Detection in Live Bacterial Cells Using Fluorescent Protein Complementation Triggered by Interaction of Two RNA Aptamers with Two RNA-Binding Peptides by Yiu, Hung-Wei, Demidov, Vadim V., Toran, Paul, Cantor, Charles R., Broude, Natalia E.

“…Many genetic and infectious diseases can be targeted at the RNA level as RNA is more accessible than DNA. We seek to develop new approaches for detection and…”
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Kinetics and Mechanism of the DNA Double Helix Invasion by Pseudocomplementary Peptide Nucleic Acids by Demidov, Vadim V., Protozanova, Ekaterina, Izvolsky, Konstantin I., Price, Christopher, Nielsen, Peter E., Frank-Kamenetskii, Maxim D.

“…If adenines and thymines in two mutually complementary mixed-base peptide nucleic acid (PNA) oligomers are substituted with diaminopurines and thiouracils,…”
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An experimental study of mechanism and specificity of peptide nucleic acid (PNA) binding to duplex DNA by Kuhn, H, Demidov, V V, Nielsen, P E, Frank-Kamenetskii, M D

“…We investigated the mechanism and kinetic specificity of binding of peptide nucleic acid clamps (bis-PNAs) to double-stranded DNA (dsDNA). Kinetic specificity…”
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Specific versus Nonspecific Binding of Cationic PNAs to Duplex DNA by Abibi, Ayome, Protozanova, Ekaterina, Demidov, Vadim V., Frank-Kamenetskii, Maxim D.

“…Although peptide nucleic acids (PNAs) are neutral by themselves, they are usually appended with positively charged lysine residues to increase their solubility…”
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PD-Loop: A Complex of Duplex DNA with an Oligonucleotide by Bukanov, Nikolay O., Demidov, Vadim V., Nielsen, Peter E., Frank-Kamenetskii, Maxim D.

“…A stable complex between duplex DNA and an oligonucleotide is assembled with the aid of a DNA synthetic mimic, peptide nucleic acid (PNA). Homopyrimidine PNAs…”
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Inducing and Modulating Anisotropic DNA Bends by Pseudocomplementary Peptide Nucleic Acids by Kuhn, Heiko, Cherny, Dmitry I., Demidov, Vadim V., Frank-Kamenetskii, Maxim D., Rich, Alexander

“…DNA bending is significant for various DNA functions in the cell. Here, we demonstrate that pseudocomplementary peptide nucleic acids (pcPNAs) represent a…”
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Response to Zhang: another trick of heavy isotopes by Demidov, Vadim V

“…Zhang's letter raises an interesting topic, partially discussed in Shchepinov's papers on the possible application of heavy isotopes to prevent ageing [1,2]…”
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Heavy isotopes to avert ageing? by Demidov, Vadim V

“…Oxidative modifications of cellular components by free radicals are thought to be the cause of ageing and age-associated diseases. Extensive prior research has…”
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PNA and LNA throw light on DNA by Demidov, Vadim V

“…In some aspects, homogeneous (all-in-solution) nucleic acid hybridization assays are superior to the traditionally used heterogeneous (solution-to-surface)…”
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Rolling-circle amplification under topological constraints by Kuhn, Heiko, Demidov, Vadim V, Frank-Kamenetskii, Maxim D

“…We have performed rolling-circle amplification (RCA) reactions on three DNA templates that differ distinctly in their topology: an unlinked DNA circle, a…”
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Stability of peptide nucleic acids in human serum and cellular extracts by Demidov, V V, Potaman, V N, Frank-Kamenetskii, M D, Egholm, M, Buchard, O, Sönnichsen, S H, Nielsen, P E

“…The stability of a new type of DNA mimic, peptide nucleic acid (PNA) in human blood serum, Eschericia coli and Micrococcus luteus extracts and nuclear and…”
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End invasion of peptide nucleic acids (PNAs) with mixed-base composition into linear DNA duplexes by Smolina, Irina V., Demidov, Vadim V., Soldatenkov, Viatcheslav A., Chasovskikh, Sergey G., Frank-Kamenetskii, Maxim D.

“…Peptide nucleic acid (PNA) is a synthetic DNA mimic with valuable properties and a rapidly growing scope of applications. With the exception of recently…”
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Profluorescent protein fragments for fast bimolecular fluorescence complementation in vitro by Demidov, Vadim V, Broude, Natalia E

“…Here, we present a protocol for isolating the large N-terminal fragment of enhanced green fluorescent protein (EGFP) with a preformed chromophore. By itself,…”
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