Pisa syndrome during aripiprazole treatment: A case report

Pisa syndrome (or pleurothotonus), consisting of a tonic flexion of the trunk, has been recently reported also in association with atypical antipsychotics. We describe the first case of Pisa syndrome during aripiprazole treatment in an elderly (77-year-old) woman, admitted to hospital for behavioura...

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Bibliographic Details
Published in:	Progress in neuro-psychopharmacology & biological psychiatry Vol. 31; no. 1; pp. 286 - 287
Main Authors:	Rota, Eugenia, Bergesio, Giovanni, Dettoni, Elisabetta, Demicheli, Claudio M.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 30-01-2007 Elsevier
Subjects:	Aged Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Aripiprazole Atypical antipsychotics Biological and medical sciences Dementia - drug therapy Dibenzothiazepines - therapeutic use Dystonia Dystonia - chemically induced Extrapyramidal side effects Female Humans Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neuropharmacology Pharmacology. Drug treatments Piperazines - adverse effects Piperazines - therapeutic use Pisa syndrome Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Quetiapine Fumarate Quinolones - adverse effects Quinolones - therapeutic use Atypical antipsychotics Dystonia Pisa syndrome Aripiprazole Extrapyramidal side effects Partial agonist Atypical antipsychotic Neuroleptic Psychotropic Toxicity Involuntary movement 5-HT1A Serotonine receptor Antagonist Neurological disorder 5-HT2A serotonin receptor Nervous system diseases Motor control Cerebral disorder Case study Striated muscle disease Chemotherapy D2 Dopamine receptor Treatment Central nervous system disease Extrapyramidal syndrome
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Summary:	Pisa syndrome (or pleurothotonus), consisting of a tonic flexion of the trunk, has been recently reported also in association with atypical antipsychotics. We describe the first case of Pisa syndrome during aripiprazole treatment in an elderly (77-year-old) woman, admitted to hospital for behavioural and psychological symptoms of dementia. The ongoing treatment with quetiapine was rapidly tapered and stopped, and a switch to aripiprazole (15 mg/die) was attempted the subsequent day. Six days later, an acute tonic flexion of trunk and head towards the right was observed. Aripiprazole was discontinued and the Pisa syndrome completely disappeared within 3 days, without any adjunctive treatment.
ISSN:	0278-5846 1878-4216
DOI:	10.1016/j.pnpbp.2006.06.009