Search Results - "Demesmay, Claire"

Ligand Screening of Membrane Proteins Embedded in Nanodiscs: How to Manage Non-Specific Interactions in Weak Affinity Chromatography? by Vidal, François-Xavier, Deloche, Adrien, Zeder-Lutz, Gabrielle, Hideux, Maria, Wagner, Renaud, Dugas, Vincent, Demesmay, Claire

“…Miniaturized weak affinity chromatography is emerging as an interesting alternative to conventional biophysical tools for performing fragment-screening studies…”
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Extending the Affinity Range of Weak Affinity Chromatography for the Identification of Weak Ligands Targeting Membrane Proteins by Deloche, Adrien, Vidal, François-Xavier, Jammas, Lucile, Wagner, Renaud, Dugas, Vincent, Demesmay, Claire

“…The identification of weak-affinity ligands targeting membrane proteins is of great interest in Fragment-Based Drug Design (FBDD). Recently, miniaturized weak…”
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Towards a Non-Biased Formaldehyde Quantification in Leather: New Derivatization Conditions before HPLC Analysis of 2,4-Dinitrophenylhydrazine Derivatives by Bourgeois, Caroline, Blanc, Nicolas, Cannot, Jean-Claude, Demesmay, Claire

“…In leathers, formaldehyde is currently analyzed according to EN ISO 17226-1 standard, by reversed phase liquid chromatography after off-line precolumn…”
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Online Separation and Identification of Isomers Using Infrared Multiple Photon Dissociation Ion Spectroscopy Coupled to Liquid Chromatography: Application to the Analysis of Disaccharides Regio-Isomers and Monosaccharide Anomers by Schindler, Baptiste, Laloy-Borgna, Gabrielle, Barnes, Loïc, Allouche, Abdul-Rahman, Bouju, Elodie, Dugas, Vincent, Demesmay, Claire, Compagnon, Isabelle

“…The vast array of molecular isomerisms which form the complex molecular structure of carbohydrates is the foundation of their biological versatility but defies…”
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Zirconia based monoliths used in hydrophilic-interaction chromatography for original selectivity of xanthines by Randon, Jérôme, Huguet, Samuel, Demesmay, Claire, Berthod, Alain

“…Monolithic capillary columns based on zirconia were prepared directly from zirconium alkoxide. They were also prepared coating a classical silica based…”
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Optimization of the Preparation of Hydrophilic Poly(DHPMA-co-MBA) Monolithic Capillary Columns: A New Support for Affinity Chromatography by Gil, Julie, Passalacqua, Gaëtan, Deloche, Adrien, Vidal, François-Xavier, Dugas, Vincent, Demesmay, Claire

“…In miniaturized affinity chromatography, the development of hydrophilic organic monoliths with reduced non-specific interactions and high-protein grafting…”
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Photografting as a versatile, localizable, and single-step surface functionalization of silica-based monoliths dedicated to microscale separation techniques by El-Debs, Racha, Dugas, Vincent, Demesmay, Claire

“…In this work, we developed a surface functionalization way of silica monoliths with a rapid, simple, versatile, and localizable photografting step. The…”
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Synthesis of zirconia monoliths for chromatographic separations by Randon, Jérôme, Huguet, Samuel, Piram, Anne, Puy, Guillaume, Demesmay, Claire, Rocca, Jean-Louis

“…The aim of this work is to join the advantages of two different kinds of stationary phases: monolithic columns and zirconia-based supports. On the one hand,…”
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Spherical ordered mesoporous silicas and silica monoliths as stationary phases for liquid chromatography by Galarneau, Anne, Iapichella, Julien, Brunel, Daniel, Fajula, François, Bayram-Hahn, Zöfre, Unger, Klaus, Puy, Guillaume, Demesmay, Claire, Rocca, Jean-Louis

“…Ordered mesoporous silicas such as micelle‐templated silicas (MTS) feature unique textural properties in addition to their high surface area (˜1000 m2/g):…”
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Development of a multi-layering protein grafting process on miniaturized monolithic columns for weak affinity nano liquid chromatography application purposes by Gottardini, Andrea, Dugas, Vincent, Demesmay, Claire

“…•Biotin-streptavidin grafting approach is enhanced by Multi-layering.•Multilayering allows a 2-fold increase in biotinylated target grafting density.•Weak…”
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Hexavalent chromium release from leather over time natural ageing vs accelerated ageing according to a multivariate approach by Fontaine, Mathilde, Clement, Yohann, Blanc, Nicolas, Demesmay, Claire

“…•A multivariate approach gives key insights into factors influencing CrVI release during storage.•Temperature and UV have synergistic effects on Cr VI…”
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Preparation of miniaturized hydrophilic affinity monoliths: Towards a reduction of non-specific interactions and an increased target protein density by GIL, Julie, Krimm, Isabelle, Dugas, Vincent, Demesmay, Claire

“…•New hydrophilic glycidyl-based monoliths were successfully prepared.•N,N’-Methylenebis(acrylamide) was used as hydrophilic crosslinker.•Non-specific…”
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Reduce cognitive overload with systemic cause-effect relation maps to teach and learn chromatography by Randon, Jérôme, Dugas, Vincent, Demesmay, Claire

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Two Original Experimental Setups for Staircase Frontal Affinity Chromatography at the Miniaturized Scale by Gottardini, Andrea, Netter, Claude, Dugas, Vincent, Demesmay, Claire

“…Frontal affinity chromatography is a powerful, underappreciated technique for the qualitative (screening) and quantitative (K d determination) evaluation of…”
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Affinity Chromatography: A Powerful Tool in Drug Discovery for Investigating Ligand/membrane Protein Interactions by Lecas, Lucile, Dugas, Vincent, Demesmay, Claire

“…Affinity chromatography is an often overlooked chromatographic technique regarding receptor/ligand studies. Indeed, biologists have a tendency to focus on more…”
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Miniaturized antithrombin III affinity monolithic columns coupled to TOF-MS for the selective capture and release of fondaparinux a high affinity antithrombin III ligand by Jeanroy, Frédéric, Demesmay, Claire, Dugas, Vincent

“…This work explores the capability of antithrombin III-functionalized capillary monolithic columns (in-line coupled with MS detection) to selectively capture,…”
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Die Deutsch-Französische Parlamentarische Versammlung – ein Schritt zur Europäisierung der Parlamente? by Demesmay, Claire, Seidendorf, Stefan

“…Parliamentary cooperation has long been a stepchild of the Franco-German relationship, but the creation of the Franco-German Parliamentary Assembly (FGPA) in…”
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Contribution of Separation Sciences to the Deciphering of the Binding Sites of Glycosaminoglycans to Proteins by Jeanroy, Frédéric, Demesmay, Claire, Dugas, Vincent

“…Following the rapid developments in genomics and proteomics in recent decades, the analysis of the associated sugars became a critical center of interest,…”
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Miniaturized affinity chromatography: A powerful technique for the isolation of high affinity GAGs sequences prior to their identification by MALDI-TOF MS by Jeanroy, Frédéric, Comby-Zerbino, Clothilde, Demesmay, Claire, Dugas, Vincent

“…Glycosaminoglycans (GAGS) are involved in many biological processes through interactions with a variety of proteins, including proteases, growth factors,…”
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Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors by Lecas, Lucile, Hartmann, Lucie, Caro, Lydia, Mohamed-Bouteben, Sarah, Raingeval, Claire, Krimm, Isabelle, Wagner, Renaud, Dugas, Vincent, Demesmay, Claire

“…Biophysical techniques that enable the screening and identification of weak affinity fragments against a target protein are at the heart of Fragment Based Drug…”
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