Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana

The aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of , a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, the following neoplastic cell lines were...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 25; no. 14; p. 3201
Main Authors:	Demenciano, Simone da Cunha, Silva, Magalli Costa Barbosa Lima E, Alexandrino, Caroline Almeida Farias, Kato Junior, Wilson Hino, Figueiredo, Patrícia de Oliveira, Garcez, Walmir Silva, Campos, Raquel Pires, Guimarães, Rita de Cássia Avellaneda, Sarmento, Ulana Chaves, Bogo, Danielle
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 14-07-2020 MDPI
Subjects:	Acids anticancer Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Antiproliferatives Ascorbic acid bacupari Biotechnology brazilian cerrado fruits Breast cancer Breast carcinoma Cancer Carotenoids Chloroform Chromatography, High Pressure Liquid Cytotoxicity Ethanol Flavonoids Free radicals Fruit - chemistry Fruit trees Fruits Garcinia Garcinia - chemistry Hexoses High performance liquid chromatography HPLC-DAD-MS Humans Ionization Leaves Liquid chromatography Mass Spectrometry Metabolites Molecular Structure Oxidative stress Phytochemicals - chemistry Phytochemicals - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Polycarboxylic acids Polyphenols Cerrado Biome HPLC-DAD-MS bacupari brazilian cerrado fruits anticancer cytotoxicity
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Summary:	The aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of , a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, the following neoplastic cell lines were considered, along with an immortalized nontumor cell line. The antioxidant potential was determined, and the evaluation of antiradical air activity was performed. The levels of vitamin C and carotenoids were determined. The chemical profile was analyzed by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer using electrospray ionization interface. The chloroform fraction of the leaf showed antioxidant activity. The vitamin C content had lower values in fruits and higher in leaves. The content of carotenoids for fruits and leaves was expressive. The ethanolic extract and the hexane and chloroform fractions of fruits were active in all neoplastic lines tested. The leaves showed cytotoxic activity in the hexane fraction in the breast carcinoma line. The analysis of data obtained verified the presence of dimers, monomers, and tetramers of hexoses, polycarboxylic acids, xanthones, flavonoids, biflavonoids, and benzophenones.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25143201