Search Results - "Demby, Tamar"
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A mouse model of chemotherapy-related cognitive impairments integrating the risk factors of aging and APOE4 genotype
Published in Behavioural brain research (20-04-2020)“…Some cancer survivors experience marked cognitive impairment, referred to as cancer-related cognitive impairment (CRCI). CRCI has been linked to the genetic…”
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3367 A Mouse Model of APOE Genotype in Chemotherapy Related Cognitive Impairment
Published in Journal of clinical and translational science (01-03-2019)“…OBJECTIVES/SPECIFIC AIMS: Chemotherapy-related cognitive impairment (CRCI) affects 15-35% of breast cancer survivors and constitutes a significant challenge…”
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The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype
Published in Experimental neurology (01-01-2024)“…Many cancer patients experience serious cognitive problems related to their treatment, which can greatly affect their quality of life. The molecular mechanisms…”
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Abstract 667: A mouse model of APOE to define effects of doxorubicin on cognition
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…The purpose of this study was to establish the effects of Apolipoprotein E (APOE) genotype on cognitive function following doxorubicin treatment in a mouse…”
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Potent and Selective Human 5-HT 2B Serotonin Receptor Antagonists: 4′-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity
Published in Journal of medicinal chemistry (26-11-2024)Get full text
Journal Article -
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Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy
Published in Neurotoxicity research (01-02-2019)“…Cancer-related cognitive impairment in breast cancer patients exposed to multi-agent chemotherapy regimens is associated with the apolipoprotein E4 ( APOE4 )…”
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Journal Article -
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The APOE4 Mouse as a Model of Chemotherapy-Induced Cognitive Impairments and Senescence
Published 01-01-2021“…Cancer-related cognitive impairment (CRCI) occurs in 15-35% of breast cancer survivors and represents a major quality of life concern. CRCI has been linked to…”
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Dissertation