Search Results - "Demaurex, N"

ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain by Bulla, M., Gyimesi, G., Kim, J.H., Bhardwaj, R., Hediger, M.A., Frieden, M., Demaurex, N.

“…Key points Gain‐of‐function mutations in the highly selective Ca2+ channel ORAI1 cause tubular aggregate myopathy (TAM) characterized by muscular pain,…”
Get full text

NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation by Serrander, Lena, Jaquet, Vincent, Bedard, Karen, Plastre, Olivier, Hartley, Oliver, Arnaudeau, Serge, Demaurex, Nicolas, Schlegel, Werner, Krause, Karl-Heinz

“…NOX5 is a ROS-generating NADPH oxidase which contains an N-terminal EF-hand region and can be activated by cytosolic Ca 2+ elevations. However the C-terminal…”
Get full text

Amiloride derivatives induce apoptosis by depleting ER Ca2+ stores in vascular endothelial cells by Park, KS, Poburko, D, Wollheim, CB, Demaurex, N

“…Background and purpose:  Amiloride derivatives are blockers of the Na+/H+ exchanger (NHE) and at micromolar concentrations have protective effects on cardiac…”
Get full text

Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells by Park, K S, Poburko, D, Wollheim, C B, Demaurex, N

“…Amiloride derivatives are blockers of the Na(+)/H(+) exchanger (NHE) and at micromolar concentrations have protective effects on cardiac and brain…”
Get full text

ORAI1 mutations cause abnormal channel gating in tubular aggregate myopathy by Böhm, J, Bulla, M, Urquhart, J, Koch, C, Newman, W, Mora, M, Moggio, M, Romero, N, Demaurex, N, Laporte, J

Get full text

The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components by Gagescu, R, Demaurex, N, Parton, R G, Hunziker, W, Huber, L A, Gruenberg, J

“…We present a biochemical and morphological characterization of recycling endosomes containing the transferrin receptor in the epithelial Madin-Darby canine…”
Get full text

Evidence for a receptor-activated Ca2+ entry pathway independent from Ca2+ store depletion in endothelial cells by Jousset, H, Malli, R, Girardin, N, Graier, W.F, Demaurex, N, Frieden, M

“…Summary Ca2+ entry in endothelial cells is a key signaling event as it prolongs the Ca2+ signal activated by a receptor agonist, and thus allows an adequate…”
Get full text

Erratum to “Evidence for a receptor-activated Ca2+ entry pathway independent from Ca2+ store depletion in endothelial cells” [Cell Calcium 43 (1) (2008) 83–94] by Jousset, H, Malli, R, Girardin, N, Graier, W.F, Demaurex, N, Frieden, M

Get full text

Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells by Demaurex, N, Lew, D P, Krause, K H

“…The filling state of intracellular Ca2+ stores has been proposed to regulate Ca2+ influx across the plasma membrane in a variety of tissues. To test this…”
Get full text

Na+/H+ antiport: modulation by ATP and role in cell volume regulation by Demaurex, N, Grinstein, S

“…Na+/H+ antiport is a major determinant of intracellular pH (pHi) and also plays an important role in the maintenance of cellular volume. Na+/H+ exchange…”
Get full text

Angiotensin II Promotes Selective Uptake of High Density Lipoprotein Cholesterol Esters in Bovine Adrenal Glomerulosa and Human Adrenocortical Carcinoma Cells Through Induction of Scavenger Receptor Class B Type I by Cherradi, Nadia, Bideau, Martine, Arnaudeau, Serge, Demaurex, Nicolas, James, Richard W, Azhar, Salman, Capponi, Alessandro M

“…Angiotensin II is one of the main physiological regulators of aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex. The hormone stimulates…”
Get full text

Intracellular pH Regulation during Spreading of Human Neutrophils by Demaurex, Nicolas, Downey, Gregory P., Waddell, Thomas K., Grinstein, Sergio

“…The regulation of the intracellular pH (pHi) during spreading of human neutrophils was studied by a combination of fluorescence imaging and video microscopy…”
Get full text

Pituitary adenylate cyclase-activating polypeptide increases [Ca2]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism by RAWLINGS, S. R, DEMAUREX, N, SCHLEGEL, W

“…Pituitary adenylate cyclase-activating polypeptide (PACAP) increases cAMP production and stimulates hormone release from a variety of anterior pituitary cells…”
Get full text

Intracellular Transport of Calcium from Plasma Membrane to Mitochondria in Adrenal H295R Cells: Implication for Steroidogenesis by Lalevée, Nathalie, Resin, Véronique, Arnaudeau, Serge, Demaurex, Nicolas, Rossier, Michel F

“…Angiotensin II and extracellular potassium stimulate aldosterone production in adrenal glomerulosa cells by mobilizing the calcium messenger system. This…”
Get full text

Proton currents in human granulocytes: regulation by membrane potential and intracellular pH by Demaurex, N, Grinstein, S, Jaconi, M, Schlegel, W, Lew, D P, Krause, K H

“…1. To determine whether conductive pathways contribute to the H+ efflux from granulocytes, we used the whole-cell patch-clamp technique combined with…”
Get full text

Apoptosis: The Calcium Connection by Demaurex, Nicolas, Distelhorst, Clark

“…Calcium ions are crucial to many cellular processes including apoptosis. In their Perspective, Demaurex and Distelhorst explain new work that shows how calcium…”
Get full text

pH Homeostasis of Cellular Organelles by Demaurex, Nicolas

“…Nicolas Demaurex Department of Physiology, University of Geneva, 1211 Geneva 4, Switzerland An optimal pH is maintained in each secretory and endocytic…”
Get full text

Calcium measurements in organelles with Ca2+-sensitive fluorescent proteins by Demaurex, Nicolas

“…The recent improvement in the design and use of genetically encoded fluorescent Ca2+ indicators should foster major progress in three aspects of Ca2+…”
Get full text

The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance by Demaurex, N, Orlowski, J, Brisseau, G, Woodside, M, Grinstein, S

“…Na+/H+ exchange in vertebrates is thought to be electroneutral and insensitive to the membrane voltage. This basic concept has been challenged by recent…”
Get full text

Remodelling of the endoplasmic reticulum during store-operated calcium entry by Shen, Wei-Wei, Frieden, Maud, Demaurex, Nicolas

“…SOCE (store‐operated calcium entry) is a ubiquitous cellular mechanism linking the calcium depletion of the ER (endoplasmic reticulum) to the activation of PM…”
Get full text