Search Results - "Demarne, Frédéric"

Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating by Griesser, Janine, Hetényi, Gergely, Kadas, Hatice, Demarne, Frédéric, Jannin, Vincent, Bernkop-Schnürch, Andreas

“…[Display omitted] It was the aim of this study to evaluate the mucus permeating properties of self-emulsifying drug delivery systems (SEDDS) exhibiting…”
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Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems by Griesser, Janine, Hetényi, Gergely, Moser, Michael, Demarne, Frédéric, Jannin, Vincent, Bernkop-Schnürch, Andreas

“…[Display omitted] •Independent from the type of peptide, docusate showed the most efficient hydrophobic ion pairing properties and was revealed as universal…”
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Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies by McCartney, Fiona, Jannin, Vincent, Chevrier, Stéphanie, Boulghobra, Hakime, Hristov, Delyan R., Ritter, Nicolas, Miolane, Cédric, Chavant, Yann, Demarne, Frédéric, Brayden, David J.

“…Labrasol® ALF (Labrasol®), is a non-ionic surfactant excipient primarily used as a solubilising agent. It was investigated here as an intestinal permeation…”
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A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure by Béduneau, Arnaud, Tempesta, Camille, Fimbel, Stéphane, Pellequer, Yann, Jannin, Vincent, Demarne, Frédéric, Lamprecht, Alf

“…[Display omitted] •A Caco-2/HT29-MTX co-culture model of the human intestinal barrier was established.•Sequential seeding of cells allowed modulating the…”
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Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione by Hetényi, Gergely, Griesser, Janine, Moser, Michael, Demarne, Frédéric, Jannin, Vincent, Bernkop-Schnürch, Andreas

“…[Display omitted] •Independent from the type of peptide, all the SEDDS showed a prolonged release.•SEDDS can provide a 100% protective effect towards protease…”
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Size characterization of commercial micelles and microemulsions by Taylor dispersion analysis by Chamieh, Joseph, Davanier, Florian, Jannin, Vincent, Demarne, Frédéric, Cottet, Hervé

“…[Display omitted] In this work, Taylor dispersion analysis was applied to the measurement of micelles (or microdroplets) molecular diffusion coefficient in…”
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Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity by Jannin, Vincent, Chevrier, Stéphanie, Michenaud, Matthieu, Dumont, Camille, Belotti, Silvia, Chavant, Yann, Demarne, Frédéric

“…[Display omitted] Lipid-based formulations can be effective drug delivery systems for poorly water-soluble chemical entities, provided they are designed with…”
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Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis by Chamieh, Joseph, Domènech Tarrat, Anna, Doudou, Cérine, Jannin, Vincent, Demarne, Frédéric, Cottet, Hervé

“…[Display omitted] Therapeutic peptides are facing an increasing interest as drugs for the treatment of many diseases. The challenge in the administration of…”
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Keratinocyte stem cells are more resistant to UVA radiation than their direct progeny by Metral, Elodie, Bechetoille, Nicolas, Demarne, Frédéric, Damour, Odile, Rachidi, Walid

“…The epidermis undergoes constant renewal during its lifetime. This is possible due to a special population of keratinocyte stem cells (KSCs) located at the…”
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Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection by Chamieh, Joseph, Merdassi, Habib, Rossi, Jean-Christophe, Jannin, Vincent, Demarne, Frédéric, Cottet, Hervé

“…[Display omitted] Self-emulsifying drug delivery systems based on lipids have gained in interest in recent years due to their capacity to enhance the…”
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Using Enzymes to Harvest Fatty Acids from Galactosyldiacylglycerols, the Most Abundant Lipids in Plant Biomass by Amara, Sawsan, Lecomte, Jérôme, Barouh, Nathalie, Sahaka, Moulay, Lafont, Dominique, Rodier, Jean-David, Parsiegla, Goetz, Demarne, Frédéric, Gontero, Brigitte, Villeneuve, Pierre, Carrière, Frédéric

“…Mono- and digalactosyldiacylglycerols (MGDG, DGDG), the main lipids of plant photosynthetic membranes, represent a large but unexploited reservoir of fatty…”
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Mitochondrial damage and cytoskeleton reorganization in human dermal fibroblasts exposed to artificial visible light similar to screen-emitted light by Rascalou, Adeline, Lamartine, Jérôme, Poydenot, Pauline, Demarne, Frédéric, Bechetoille, Nicolas

“…•Accurate modeling of artificial visible light emitted by electronic devices.•Strong transcriptome response in dermal fibroblasts.•Fragmented mitochondrial…”
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Long‐term Genoprotection Effect of Sechium edule Fruit Extract Against UVA Irradiation in Keratinocytes by Metral, Elodie, Rachidi, Walid, Damour, Odile, Demarne, Frédéric, Bechetoille, Nicolas

“…Photoprotection is essential to prevent the long‐term deleterious effects of ultraviolet (UV), including skin cancer and photoaging. So far, there has been an…”
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Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection by Chamieh, Joseph, Jannin, Vincent, Demarne, Frédéric, Cottet, Hervé

“…[Display omitted] In this work, the sizing of microemulsion droplets of a lipid-based pharmaceutical excipient (Labrasol® ALF) is performed by Taylor…”
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Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray-flash evaporation by Jannin, Vincent, Blas, Lucia, Chevrier, Stéphanie, Miolane, Cédric, Demarne, Frédéric, Spitzer, Denis

“…To evaluate the digestibility of Solid Lipid Nanoparticles (SLN) of glyceryl dibehenate prepared either with surfactants by ultrasonication or without…”
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In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates by Dubray, Océane, Jannin, Vincent, Demarne, Fréderic, Pellequer, Yann, Lamprecht, Alf, Béduneau, Arnaud

“…[Display omitted] In this present study, the secretory transport of P-gp substrates, rhodamine 123 and digoxin, was evaluated using a Caco-2/HT29-MTX…”
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In Vitro Digestion of the Self-Emulsifying Lipid Excipient Labrasol® by Gastrointestinal Lipases and Influence of its Colloidal Structure on Lipolysis Rate by Fernandez, Sylvie, Jannin, Vincent, Chevrier, Stéphanie, Chavant, Yann, Demarne, Frédéric, Carrière, Frédéric

“…ABSTRACT Purpose Labrasol ® is a self-emulsifying excipient used to improve the oral bioavailability of poorly water-soluble drugs. It is a mixture of…”
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Biorelevant media resistant co-culture model mimicking permeability of human intestine by Antoine, Delphine, Pellequer, Yann, Tempesta, Camille, Lorscheidt, Stefan, Kettel, Bernadette, Tamaddon, Lana, Jannin, Vincent, Demarne, Frédéric, Lamprecht, Alf, Béduneau, Arnaud

“…[Display omitted] Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract…”
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Modulation of transepithelial electric resistance (TEER) in reconstructed human epidermis by excipients known to permeate intestinal tight junctions by Abdayem, Rawad, Callejon, Sylvie, Portes, Pascal, Kirilov, Plamen, Demarne, Frédéric, Pirot, Fabrice, Jannin, Vincent, Haftek, Marek

“…Several excipients are commonly used to enhance the drug absorption through simple epithelia of the digestive tract. They permeate the paracellular barrier…”
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In Vitro Gastrointestinal Lipolysis of Four Formulations of Piroxicam and Cinnarizine with the Self Emulsifying Excipients Labrasol® and Gelucire® 44/14 by Fernandez, Sylvie, Chevrier, Stéphanie, Ritter, Nicolas, Mahler, Bruno, Demarne, Frédéric, Carrière, Frédéric, Jannin, Vincent

“…Purpose Labrasol® and Gelucire® 44/14 are defined admixtures of acylglycerols and PEG esters which are substrates for digestive lipases. Methods We…”
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