Search Results - "Demaria, M"

A Senescence-Centric View of Aging: Implications for Longevity and Disease by Borghesan, M., Hoogaars, W.M.H., Varela-Eirin, M., Talma, N., Demaria, M.

“…Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules…”
Get full text

Algorithmic assessment of cellular senescence in experimental and clinical specimens by Kohli, J., Wang, B., Brandenburg, S. M., Basisty, N., Evangelou, K., Varela-Eirin, M., Campisi, J., Schilling, B., Gorgoulis, V., Demaria, M.

“…The development of genetic tools allowed for the validation of the pro-aging and pro-disease functions of senescent cells in vivo. These discoveries prompted…”
Get full text

Scaled distribution mapping: a bias correction method that preserves raw climate model projected changes by Switanek, Matthew B, Troch, Peter A, Castro, Christopher L, Leuprecht, Armin, Chang, Hsin-I, Mukherjee, Rajarshi, Demaria, Eleonora M. C

“…Commonly used bias correction methods such as quantile mapping (QM) assume the function of error correction values between modeled and observed distributions…”
Get full text

An Overview of the TROPICS NASA Earth Venture Mission by Blackwell, W. J., Braun, S., Bennartz, R., Velden, C., DeMaria, M., Atlas, R., Dunion, J., Marks, F., Rogers, R., Annane, B., Leslie, R. V.

“…The Time-Resolved Observations of Precipitation structure and storm Intensity with a Constellation of Smallsats (TROPICS) mission was selected by NASA as part…”
Get full text

To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes by van Vliet, T., Casciaro, F., Demaria, M.

“…•Oxygen-sensing pathways are involved in regulating different hallmarks of aging.•Chronic hypoxic and hyperoxic conditions associate with various…”
Get full text

Long term effect of air pollution on incident hospital admissions: Results from the Italian Longitudinal Study within LIFE MED HISS project by Gandini, M., Scarinzi, C., Bande, S., Berti, G., Carnà, P., Ciancarella, L., Costa, G., Demaria, M., Ghigo, S., Piersanti, A., Rowinski, M., Spadea, T., Stroscia, M., Cadum, E.

“…The LIFE MED HISS project aims at setting up a surveillance system on the long term effects of air pollution on health, using data from National Health…”
Get full text

Declines in northern forest tree growth following snowpack decline and soil freezing by Reinmann, Andrew B., Susser, Jessica R., Demaria, Eleonora M. C., Templer, Pamela H.

“…Changes in growing season climate are often the foci of research exploring forest response to climate change. By contrast, little is known about tree growth…”
Get full text

Cellular senescence in brain aging and neurodegeneration by Melo Dos Santos, L S, Trombetta-Lima, M, Eggen, Bjl, Demaria, M

“…Cellular senescence is a state of terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory phenotype. In the brain,…”
Get full text

Monte Carlo sensitivity analysis of land surface parameters using the Variable Infiltration Capacity model by Demaria, Eleonora M., Nijssen, Bart, Wagener, Thorsten

“…Current land surface models use increasingly complex descriptions of the processes that they represent. Increase in complexity is accompanied by an increase in…”
Get full text

Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways by Imbroisi Filho, Ricardo, Ochioni, Alan C., Esteves, Amanda M., Leandro, João G. B., Demaria, Thainá M., Sola-Penna, Mauro, Zancan, Patricia

“…Among the principal causative factors for the development of complications related to aging is a diet rich in fats and sugars, also known as the Western diet…”
Get full text

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease? by Chinta, S. J., Lieu, C. A., DeMaria, M., Laberge, R.‐M., Campisi, J., Andersen, J. K.

“…Exposure to environmental toxins is associated with a variety of age‐related diseases including cancer and neurodegeneration. For example, in Parkinson's…”
Get full text

Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation by Soto-Gamez, A., van Es, M., Hageman, E., Serna-Salas, S.A., Moshage, H., Demaria, M., Pringle, S., Coppes, R.P.

“…[Display omitted] •Adipose-derived Mesenchymal Stem cells are a source of hepatocyte growth factor (HGF).•Adult salivary gland stem/progenitor cells remain…”
Get full text

Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease by Lin, Y., Postma, D. F., Steeneken, L. S., Melo dos Santos, L. S., Kirkland, J. L., Espindola‐Netto, J. M., Tchkonia, T., Borghesan, M., Bouma, H. R., Demaria, M.

“…Accurate biomarkers for predicting COVID‐19 severity have remained an unmet need due to an incomplete understanding of virus pathogenesis and heterogeneity…”
Get full text

Sexual and reproductive health in Ethiopia: gains and reflections over the past two decades by DeMaria, Lisa M, Smith, Kimberly V, Berhane, Yemane

“…Over the past two decades, through a series of concerted policies, programs, and commitments, Ethiopia has made notable advances in improving the reproductive…”
Get full text

Clotrimazole presents anticancer properties against a mouse melanoma model acting as a PI3K inhibitor and inducing repolarization of tumor-associated macrophages by Ochioni, Alan C, Imbroisi Filho, Ricardo, Esteves, Amanda M, Leandro, João G B, Demaria, Thainá M, do Nascimento Júnior, José Xavier, Pereira-Dutra, Filipe S, Bozza, Patricia T, Sola-Penna, Mauro, Zancan, Patricia

“…The immune system is a key component of tumorigenesis, with the latter promoting the development of cancer, its progression and metastasis. In fact, abundant…”
Get more information

STAT3 can serve as a hit in the process of malignant transformation of primary cells by Demaria, M, Misale, S, Giorgi, C, Miano, V, Camporeale, A, Campisi, J, Pinton, P, Poli, V

“…The transcription factor signal transducer and activator of transcription 3 (STAT3) acts downstream of many pro-oncogenic signals, including cytokines, growth…”
Get full text

Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis by Ausina, Priscila, Branco, Jessica R., Demaria, Thainá M., Esteves, Amanda M., Leandro, João Gabriel B., Ochioni, Alan C., Mendonça, Ana Paula M., Palhano, Fernando L., Oliveira, Marcus F., Abou-Kheir, Wassim, Sola-Penna, Mauro, Zancan, Patricia

“…Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative. Acetylsalicylic acid (ASA; Aspirin) and salicylic acid (SA)…”
Get full text

Dietary citrate acutely induces insulin resistance and markers of liver inflammation in mice by Branco, Jessica Ristow, Esteves, Amanda Moreira, Leandro, João Gabriel Bernardo, Demaria, Thainá M., Godoi, Vilma, Marette, André, Valença, Helber da Maia, Lanzetti, Manuella, Peyot, Marie-Line, Farfari, Salah, Prentki, Marc, Zancan, Patricia, Sola-Penna, Mauro

“…Citrate is widely used as a food additive being part of virtually all processed foods. Although considered inert by most of the regulatory agencies in the…”
Get full text

Change in telomere length and cardiovascular risk factors in testicular cancer survivors by Volders, Ellen L D, Meijer, Coby, Steeneken, Lotte S, Lubberts, Sjoukje, Zwart, Nynke, van Roon, Arie M, Lefrandt, Joop D, de Jong, Igle J, Demaria, M, Nuver, Janine, Gietema, Jourik A

“…Testicular cancer (TC) survivors cured with chemotherapy (CT) are prone to develop cardiovascular diseases, as part of an accelerated aging phenotype. A…”
Get full text

Promoting wellbeing and empowerment via Youth First: Exploring psychosocial outcomes of a school-based resilience intervention in Bihar, India by Leventhal, Katherine S., Cooper, Peter L., DeMaria, Lisa M., Priyam, Priyadarshi, Shanker, Hari, Andrew, Gracy, Leventhal, Steve

“…Youth worldwide are struggling with increased mental health concerns. As youth in low- and middle-income countries make up more than 20% of the world’s…”
Get full text