Search Results - "Demarest, Tyler G."

NAD+ in Aging: Molecular Mechanisms and Translational Implications by Fang, Evandro F., Lautrup, Sofie, Hou, Yujun, Demarest, Tyler G., Croteau, Deborah L., Mattson, Mark P., Bohr, Vilhelm A.

“…The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may…”
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Self‐assembly of multi‐component mitochondrial nucleoids via phase separation by Feric, Marina, Demarest, Tyler G, Tian, Jane, Croteau, Deborah L, Bohr, Vilhelm A, Misteli, Tom

“…Mitochondria contain an autonomous and spatially segregated genome. The organizational unit of their genome is the nucleoid, which consists of mitochondrial…”
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Sex‐dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic‐ischemic encephalopathy by Demarest, Tyler G., Schuh, Rosemary A., Waddell, Jaylyn, McKenna, Mary C., Fiskum, Gary

“…Increased male susceptibility to long‐term cognitive deficits is well described in clinical and experimental studies of neonatal hypoxic‐ischemic…”
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Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response by Bordt, Evan A., Smith, Caroline J., Demarest, Tyler G., Bilbo, Staci D., Kingsbury, Marcy A.

“…Neuroendocrine and immune signaling pathways are activated following insults such as stress, injury, and infection, in a systemic response aimed at restoring…”
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NAD+ Metabolism in Aging and Cancer by Demarest, Tyler G, Babbar, Mansi, Okur, Mustafa N, Dan, Xiuli, Croteau, Deborah L, Fakouri, Nima B, Mattson, Mark P, Bohr, Vilhelm A

“…Aging is a major risk factor for many types of cancer, and the molecular mechanisms implicated in aging, progeria syndromes, and cancer pathogenesis display…”
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Translation of gene therapy strategies for amyotrophic lateral sclerosis by Demarest, Tyler G., Biferi, Maria Grazia

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Sex differences in mitochondrial (dys)function: Implications for neuroprotection by Demarest, Tyler G., McCarthy, Margaret M.

“…Decades of research have revealed numerous differences in brain structure size, connectivity and metabolism between males and females. Sex differences in…”
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High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs by Francis, T. Chase, Yano, Hideaki, Demarest, Tyler G., Shen, Hui, Bonci, Antonello

“…Subtypes of nucleus accumbens medium spiny neurons (MSNs) promote dichotomous outcomes in motivated behaviors. However, recent reports indicate enhancing…”
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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome by Fang, Evandro F., Hou, Yujun, Lautrup, Sofie, Jensen, Martin Borch, Yang, Beimeng, SenGupta, Tanima, Caponio, Domenica, Khezri, Rojyar, Demarest, Tyler G., Aman, Yahyah, Figueroa, David, Morevati, Marya, Lee, Ho-Joon, Kato, Hisaya, Kassahun, Henok, Lee, Jong-Hyuk, Filippelli, Deborah, Okur, Mustafa Nazir, Mangerich, Aswin, Croteau, Deborah L., Maezawa, Yoshiro, Lyssiotis, Costas A., Tao, Jun, Yokote, Koutaro, Rusten, Tor Erik, Mattson, Mark P., Jasper, Heinrich, Nilsen, Hilde, Bohr, Vilhelm A.

“…Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN)…”
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Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation by Okur, Mustafa N, Lee, Jong-Hyuk, Osmani, Wasif, Kimura, Risako, Demarest, Tyler G, Croteau, Deborah L, Bohr, Vilhelm A

“…Abstract Cockayne Syndrome (CS) is a rare neurodegenerative disease characterized by short stature, accelerated aging and short lifespan. Mutations in two…”
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Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction by Sun, Chongkui, Wang, Kun, Stock, Amanda J, Gong, Yi, Demarest, Tyler G, Yang, Beimeng, Giri, Neelam, Harrington, Lea, Alter, Blanche P, Savage, Sharon A, Bohr, Vilhelm A, Liu, Yie

“…Short telomeres are a principal defining feature of telomere biology disorders, such as dyskeratosis congenita (DC), for which there are no effective…”
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Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction by Demarest, Tyler G., Varma, Vijay R., Estrada, Darlene, Babbar, Mansi, Basu, Sambuddha, Mahajan, Uma V., Moaddel, Ruin, Croteau, Deborah L., Thambisetty, Madhav, Mattson, Mark P., Bohr, Vilhelm A.

“…Alzheimer’s disease (AD) is an incurable neurodegenerative disease that is more prevalent in women. The increased risk of AD in women is not well understood…”
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Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging by Lee, Jong-Hyuk, Demarest, Tyler G, Babbar, Mansi, Kim, Edward W, Okur, Mustafa N, De, Supriyo, Croteau, Deborah L, Bohr, Vilhelm A

“…Cockayne syndrome is an accelerated aging disorder, caused by mutations in the CSA or CSB genes. In CSB-deficient cells, poly (ADP ribose) polymerase (PARP) is…”
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Toward understanding genomic instability, mitochondrial dysfunction and aging by Fakouri, Nima B., Hou, Yujun, Demarest, Tyler G., Christiansen, Louise S., Okur, Mustafa N., Mohanty, Joy G., Croteau, Deborah L., Bohr, Vilhelm A.

“…The biology of aging is an area of intense research, and many questions remain about how and why cell and organismal functions decline over time. In mammalian…”
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Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle by Demarest, Tyler G., Truong, Gia Thinh D., Lovett, Jacqueline, Mohanty, Joy G., Mattison, Julie A., Mattson, Mark P., Ferrucci, Luigi, Bohr, Vilhelm A., Moaddel, Ruin

“…The reduction-oxidation state of NAD+/NADH is critical for cellular health with NAD+ and its metabolites playing critical roles in aging and pathologies. Given…”
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Brain regional angiogenic potential at the neurovascular unit during normal aging by Murugesan, Nivetha, Demarest, Tyler G, Madri, Joseph A, Pachter, Joel S

“…Abstract Given strong regional specialization of the brain, cerebral angiogenesis may be regionally modified during normal aging. To test this hypothesis,…”
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Rapid expression profiling of brain microvascular endothelial cells by immuno-laser capture microdissection coupled to TaqMan® Low Density Array by Demarest, Tyler G., Murugesan, Nivetha, Shrestha, Bandana, Pachter, Joel S.

“…Immuno-laser capture microdissection (immuno-LCM) enables highly selective retrieval of designated cell populations from their in situ locations in complex…”
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mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy by Chandrasekaran, Krish, Muragundla, Anjaneyulu, Demarest, Tyler G., Choi, Joungil, Sagi, Avinash R., Najimi, Neda, Kumar, Pranith, Singh, Anmol, Ho, Cheng‐Ying, Fiskum, Gary, Koch, Lauren G., Britton, Steven L., Russell, James W.

“…Objectives There is a critical need to develop effective treatments for diabetic neuropathy. This study determined if a selective mGluR2/3 receptor agonist…”
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Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity by Choi, Joungil, Chandrasekaran, Krish, Demarest, Tyler G., Kristian, Tibor, Xu, Su, Vijaykumar, Kadambari, Dsouza, Kevin Geoffrey, Qi, Nathan R., Yarowsky, Paul J., Gallipoli, Rao, Koch, Lauren G., Fiskum, Gary M., Britton, Steven L., Russell, James W.

“…Objectives Diabetes leads to cognitive impairment and is associated with age‐related neurodegenerative diseases including Alzheimer's disease (AD). Thus,…”
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Rapid expression profiling of brain microvascular endothelial cells by immuno-laser capture microdissection coupled to TaqManARG Low Density Array by Demarest, Tyler G, Murugesan, Nivetha, Shrestha, Bandana, Pachter, Joel S

“…Immuno-laser capture microdissection (immuno-LCM) enables highly selective retrieval of designated cell populations from their in situ locations in complex…”
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