Search Results - "Demarest, J."

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface by Lewis, Steven M, Wu, Xiufeng, Pustilnik, Anna, Sereno, Arlene, Huang, Flora, Rick, Heather L, Guntas, Gurkan, Leaver-Fay, Andrew, Smith, Eric M, Ho, Carolyn, Hansen-Estruch, Christophe, Chamberlain, Aaron K, Truhlar, Stephanie M, Conner, Elaine M, Atwell, Shane, Kuhlman, Brian, Demarest, Stephen J

“…Bispecifics by orthogonal interfaces To improve correct antibody heavy-light chain pairing during bispecific antibody assembly, Lewis et al. design antibody…”
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A broad range of Fab stabilities within a host of therapeutic IgGs by Garber, Ellen, Demarest, Stephen J.

“…Although the functional properties of IgGs are well known, little has been published concerning the stability of whole IgG molecules. Stability is, however, a…”
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Fully On-Chip MAC at 14 nm Enabled by Accurate Row-Wise Programming of PCM-Based Weights and Parallel Vector-Transport in Duration-Format by Narayanan, P., Ambrogio, S., Okazaki, A., Hosokawa, K., Tsai, H., Nomura, A., Yasuda, T., Mackin, C., Lewis, S. C., Friz, A., Ishii, M., Kohda, Y., Mori, H., Spoon, K., Khaddam-Aljameh, R., Saulnier, N., Bergendahl, M., Demarest, J., Brew, K. W., Chan, V., Choi, S., Ok, I., Ahsan, I., Lie, F. L., Haensch, W., Narayanan, V., Burr, G. W.

“…Hardware acceleration of deep learning using analog non-volatile memory (NVM) requires large arrays with high device yield, high accuracy Multiply-ACcumulate…”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by McCue, Amelia C, Demarest, Stephen J, Froning, Karen J, Hickey, Michael J, Antonysamy, Stephen, Kuhlman, Brian

“…T-cell engaging (TCE) bispecific antibodies are potent drugs that trigger the immune system to eliminate cancer cells, but administration can be accompanied by…”
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Computationally Designed Bispecific Antibodies using Negative State Repertoires by Leaver-Fay, Andrew, Froning, Karen J., Atwell, Shane, Aldaz, Hector, Pustilnik, Anna, Lu, Frances, Huang, Flora, Yuan, Richard, Hassanali, Saleema, Chamberlain, Aaron K., Fitchett, Jonathan R., Demarest, Stephen J., Kuhlman, Brian

“…A challenge in the structure-based design of specificity is modeling the negative states, i.e., the complexes that you do not want to form. This is a difficult…”
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Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics by Froning, Karen, Maguire, Jack, Sereno, Arlene, Huang, Flora, Chang, Shawn, Weichert, Kenneth, Frommelt, Anton J., Dong, Jessica, Wu, Xiufeng, Austin, Heather, Conner, Elaine M., Fitchett, Jonathan R., Heng, Aik Roy, Balasubramaniam, Deepa, Hilgers, Mark T., Kuhlman, Brian, Demarest, Stephen J.

“…Recombinant T cell receptors (TCRs) can be used to redirect naïve T cells to eliminate virally infected or cancerous cells; however, they are plagued by low…”
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Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators by Wright, Peter E, Demarest, Stephen J, Martinez-Yamout, Maria, Chung, John, Chen, Hongwu, Xu, Wei, Dyson, H. Jane, Evans, Ronald M

“…Nuclear hormone receptors are ligand-activated transcription factors that regulate the expression of genes that are essential for development, reproduction and…”
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Generalizable design parameters for soluble T cell receptor-based T cell engagers by Froning, Karen J, Sereno, Arlene, Huang, Flora, Demarest, Stephen J

“…While most biological and cellular immunotherapies recognize extracellular targets, T cell receptor (TCR) therapeutics are unique in their ability to recognize…”
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Stability engineering of scFvs for the development of bispecific and multivalent antibodies by Miller, Brian R., Demarest, Stephen J., Lugovskoy, Alexey, Huang, Flora, Wu, Xiufeng, Snyder, William B., Croner, Lisa J., Wang, Norman, Amatucci, Aldo, Michaelson, Jennifer S., Glaser, Scott M.

“…Single-chain Fvs (scFvs) are commonly used building blocks for creating engineered diagnostic and therapeutic antibody molecules. Bispecific antibodies (BsAbs)…”
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Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen /Deuterium-Exchange and Peptide Mass Mapping by Houde, Damian, Demarest, Stephen J.

“…The structural features of the asymmetric activated states of the insulin receptor family are still poorly understood. We investigated hydrogen/deuterium…”
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An evaluation of Fuchs-Sondheimer and Mayadas-Shatzkes models below 14nm node wide lines by Smith, R. S., Ryan, E. T., Hu, C.-K., Motoyama, K., Lanzillo, N., Metzler, D., Jiang, L., Demarest, J., Quon, R., Gignac, L., Breslin, C., Giannetta, A., Wright, S.

“…The applicability of the Fuchs-Sondheimer and Mayadas-Shatzkes scattering models below the 14nm node with wide interconnect trenches of variable aspect ratio…”
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Emerging antibody combinations in oncology by Demarest, Stephen J., Hariharan, Kandasamy, Dong, Jianying

“…The use of monoclonal antibodies (mAbs) has become a general approach for specifically targeting and treating human disease. In oncology, the therapeutic…”
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Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response by Dong, Jianying, Demarest, Stephen J, Sereno, Arlene, Tamraz, Susan, Langley, Emma, Doern, Adam, Snipas, Tracey, Perron, Keli, Joseph, Ingrid, Glaser, Scott M, Ho, Steffan N, Reff, Mitchell E, Hariharan, Kandasamy

“…The insulin-like growth factor-I receptor (IGF-IR) is a cell surface receptor tyrosine kinase that mediates cell survival signaling and supports tumor…”
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Manufacturing Yield Improvement for Advanced CMOS Technology Middle-of-Line Interconnect with Cobalt Metallization : YE: YieldEnhancement/Learning by Fan, S.-C., Jamison, P., Pancharatnam, S., Sankarapandian, M., Xie, R., Waskiewicz, C., Strane, J., Lee, J., Shobha, H., Demarest, J., Peethala, C., Jagannathan, H., Wynne, J.

“…Middle of Line (MOL) metallization with cobalt has been very promising to reduce the parasitic resistance of advanced CMOS devices. Though significant line…”
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Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR by Michaelson, Jennifer S., Demarest, Stephen J., Miller, Brian, Amatucci, Aldo, Snyder, William B., Wu, Xiufeng, Huang, Flora, Phan, Samantha, Gao, Sharon, Doern, Adam, Farrington, Graham K., Lugovskoy, Alexey A., Joseph, Ingrid, Bailly, Veronique, Wang, Xin, Garber, Ellen, Browning, Jeff, Glaser, Scott M.

“…Bispecific antibodies (BsAbs) represent an emerging class of biologics that achieve dual targeting with a single agent. Recombinant DNA technologies have…”
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Phase Change Memory-based Hardware Accelerators for Deep Neural Networks (invited) by Burr, Geoffrey W., Narayanan, P., Ambrogio, S., Okazaki, A., Tsai, H., Hosokawa, K., Mackin, C., Nomura, A., Yasuda, T., Demarest, J., Brew, K. W., Chan, V., Choi, S., Gordon, T., Levin, T. M., Friz, A., Ishii, M., Kohda, Y., Chen, A., Fasoli, A., Luquin, J., Saulnier, N., Teehan, S., Ahsan, I., Narayanan, V.

“…Analog non-volatile memory (NVM)-based accelerators for deep neural networks implement multiply-accumulate (MAC) operations - in parallel, on large arrays of…”
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Building blocks for bispecific and trispecific antibodies by Wu, Xiufeng, Demarest, Stephen J.

“…Bispecific antibodies (BsAbs), which target two antigens or epitopes, incorporate the specificities and properties of two distinct monoclonal antibodies (mAbs)…”
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Process Challenge in Analog Computing Hardware using Phase Change Memory (PCM) by Chan, Victor, Ok, I., Choi, S., Gordon, T., Arnold, N., Saraf, I., McDermott, S., Brew, K., Philip, T., Utomo, H., Tseng, W.-T., Silvestre, C., Li, N., Li, J., Demarest, J., Han, J.-P., Gasasira, A., Pujari, R., Saulnier, N., Teehan, S., Ahsan, Ishtiaq

“…We discuss the process challenges such as the heater geometry effect, heater patterning processes and deep via formation. Based on the electrical data, we…”
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Selective Enablement of Dual Dipoles for near Bandedge Multi-Vt Solution in High Performance FinFET and Nanosheet Technologies by Bao, R., Watanabe, K., Zhang, J., Zhou, H., Sankarapandian, M., Li, J., Pancharatnam, S., Jamison, P., Southwick, R. G, Wang, M., Demarest, J. J, Guo, J., Loubet, N., Basker, V., Guo, D., Narayanan, V., Haran, B., Bu, H., Khare, M.

“…We report that n-dipole and p-dipole (dual dipoles) can be co-integrated to provide a more flexible volumeless multiple threshold voltage(multi-Vt) solution in…”
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Conserved amino acid networks involved in antibody variable domain interactions by Wang, Norman, Smith, William F., Miller, Brian R., Aivazian, Dikran, Lugovskoy, Alexey A., Reff, Mitchell E., Glaser, Scott M., Croner, Lisa J., Demarest, Stephen J.

“…Engineered antibodies are a large and growing class of protein therapeutics comprising both marketed products and many molecules in clinical trials in various…”
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