Search Results - "Delude, R"

Extremely low doses of tissue factor pathway inhibitor decrease mortality in a rabbit model of septic shock by MATYAL, R, VIN, Y, DELUDE, R. L, LEE, C, CREASEY, A. A, FINK, M. P

“…We sought to determine the lowest dose of recombinant human tissue factor pathway inhibitor (TFPI) that can provide protection from lethality in a rabbit model…”
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Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats by Wattanasirichaigoon, S, Menconi, M J, Delude, R L, Fink, M P

“…In a reductionist in vitro system, intestinal epithelial permeability appears to be dependent on cellular ATP content. In order to extend these prior…”
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CD14 Enhances Cellular Responses to Endotoxin without Imparting Ligand- Specific Recognition by Delude, Russell L., Savedra, Ricardo, Zhao, Huilin, Thieringer, Rolf, Yamamoto, Shunsuke, Fenton, Matthew J., Golenbock, Douglas T.

“…Binding of the lipid A portion of bacterial lipopolysaccharide (LPS) to leukocyte CD14 activates phagocytes and initiates the septic shock syndrome. Two lipid…”
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Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine by King, Carroll J, Tytgat, Stefaan, Delude, Russell L, Fink, Mitchell P

“…OBJECTIVE:We sought to test the hypothesis that ileal mucosal oxygen consumption is impaired in endotoxemic rats. METHODS:Male Sprague-Dawley rats were…”
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Polarized transport of hydrophilic compounds across rat colonic mucosa from serosa to mucosa is temperature dependent by Tomita, Mikio, Menconi ‡, Michael J., Delude ‡, Russell L., Fink ‡, Mitchell P.

“…Background & Aims: In both clinical and experimental studies, intestinal epithelial barrier function is routinely assessed by measuring mucosal permeability to…”
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CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity by R L Delude, M J Fenton, R Savedra, Jr, P Y Perera, S N Vogel, R Thieringer, D T Golenbock

“…During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of…”
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Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction by Delude, R L, Yoshimura, A, Ingalls, R R, Golenbock, D T

“…Gram-negative bacterial LPS is a potent activator of inflammatory responses. The binding of LPS to CD14 initiates signal transduction; however, the molecular…”
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Lisofylline ameliorates intestinal mucosal barrier dysfunction caused by ischemia and ischemia/reperfusion by Wattanasirichaigoon, S, Menconi, M J, Delude, R L, Fink, M P

“…In an effort to determine whether treatment with lisofylline (LSF) ameliorates intestinal barrier dysfunction in rats subjected to mesenteric ischemia and…”
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CD11/CD18 and CD14 Share a Common Lipid A Signaling Pathway by Ingalls, Robin R, Monks, Brian G, Savedra, Ricardo, Jr, Christ, William J, Delude, Russell L, Medvedev, Andrei E, Espevik, Terje, Golenbock, Douglas T

“…The activation of phagocytes by the lipid A moiety of LPS has been implicated in the pathogenesis of Gram-negative sepsis. While two LPS receptors, CD14 and…”
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Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system by Savedra, R, Jr, Delude, RL, Ingalls, RR, Fenton, MJ, Golenbock, DT

“…Phagocytic leukocytes respond to a variety of bacterial products including Gram-negative bacterial LPS and mycobacterial lipoarabinomannan (LAM). Anti-CD14…”
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Bacterial Lipopolysaccharide Induces Expression of the Stress Response Genes hop and H411 by Heine, Holger, Delude, Russell L., Monks, Brian G., Espevik, Terje, Golenbock, Douglas T.

“…CD14-transfected Chinese hamster ovary K1 fibroblasts (CHO/CD14) respond to lipopolysaccharide (LPS) by metabolizing arachidonic acid and with translocation of…”
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The CD11/CD18 integrins: characterization of three novel LPS signaling receptors by Ingalls, R R, Arnaout, M A, Delude, R L, Flaherty, S, Savedra, Jr, R, Golenbock, D T

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Hypoxic signal transduction in critical illness by Bertges, Daniel J, Fink, Mitchell P, Delude, Russell L

“…Derangements in tissue perfusion occur during critical illness, and the resulting deficit in oxygen delivery may play an important role in the pathogenesis of…”
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Immunostimulated enterocytes activate extracellular arginase I which competes with enterocyte inducible nitric oxide synthase for arginine during inflammation by Miki, K, Delude, R, Killeen, M

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Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance by Aneja, Rajesh K., Tsung, Allan, Sjodin, Hanna, Gefter, Julia V., Delude, Russell L., Billiar, Timothy R., Fink, Mitchell P.

“…High mobility group box protein 1 (HMGB1) modulates the innate immune response when present in the extracellular compartment. Receptors for HMGB1 include TLR4,…”
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AGENT BASED MODEL OF CELL CULTURE EPITHELIAL BARRIER FUNCTION: USING COMPUTER SIMULATION IN CONJUNTION WITH A BASIC SCIENCE MODEL: 36 by An, G., Delude, R.

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Characterization of genes which are deactivated upon the onset of development in Dictyostelium discoideum by Singleton, Charles K., Delude, Russell L., McPherson, Clifton E.

“…We have identified and begun characterizations of the differential expression of 15 genes whose corresponding mRNA levels decrease during the preaggregative…”
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ACCELERATED REMOVAL OF TNF WITHIN A HEMOADSORPTION DEVICE USED TO TREAT SEPSIS by Kimmel, J D, Lacko, C S, Delude, R L, Federspiel, W J

“…Objectives: Sepsis, systemic inflammation due to infection, is characterized by high concentrations of inflammatory cytokines in the circulating blood…”
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Use of CD14 transfected cells to study LPS-antagonist action by Delude, R L, Savedra, Jr, R, Yamamoto, S, Golenbock, D T

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Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact by Wurfel, M M, Monks, B G, Ingalls, R R, Dedrick, R L, Delude, R, Zhou, D, Lamping, N, Schumann, R R, Thieringer, R, Fenton, M J, Wright, S D, Golenbock, D

“…Gram-negative bacterial lipopolysaccharide (LPS) stimulates phagocytic leukocytes by interacting with the cell surface protein CD14. Cellular responses to LPS…”
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