Search Results - "Delpech, Helène"

Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies by Ashraf, Yahya, Mansouri, Hanane, Laurent-Matha, Valérie, Alcaraz, Lindsay B, Roger, Pascal, Guiu, Séverine, Derocq, Danielle, Robin, Gautier, Michaud, Henri-Alexandre, Delpech, Helène, Jarlier, Marta, Pugnière, Martine, Robert, Bruno, Puel, Anthony, Martin, Lucie, Landomiel, Flavie, Bourquard, Thomas, Achour, Oussama, Fruitier-Arnaudin, Ingrid, Pichard, Alexandre, Deshayes, Emmanuel, Turtoi, Andrei, Poupon, Anne, Simony-Lafontaine, Joëlle, Boissière-Michot, Florence, Pirot, Nelly, Bernex, Florence, Jacot, William, du Manoir, Stanislas, Theillet, Charles, Pouget, Jean-Pierre, Navarro-Teulon, Isabelle, Bonnefoy, Nathalie, Pèlegrin, André, Chardès, Thierry, Martineau, Pierre, Liaudet-Coopman, Emmanuelle

“…Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic…”
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An auristatin‐based antibody‐drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer by Bourillon, Laura, Bourgier, Céline, Gaborit, Nadège, Garambois, Véronique, Llès, Eva, Zampieri, Alexandre, Ogier, Charline, Jarlier, Marta, Radosevic‐Robin, Nina, Orsetti, Béatrice, Delpech, Hélène, Theillet, Charles, Colombo, Pierre‐Emmanuel, Azria, David, Pèlegrin, André, Larbouret, Christel, Chardès, Thierry

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer characterized by poor response to chemotherapy and radiotherapy due to the lack of efficient…”
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In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and SOX2 by Manoir, Stanislas, Delpech, Hélène, Orsetti, Béatrice, Jacot, William, Pirot, Nelly, Noel, Jean, Colombo, Pierre‐Emmanuel, Sardet, Claude, Theillet, Charles

“…Most high‐grade ovarian carcinomas (HGOCs) are sensitive to carboplatin (CBP)‐based chemotherapy but frequently recur within 24 months. Recurrent tumors remain…”
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Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer by Batnini, Kalil, Houles, Thibault, Kirsh, Olivier, Du Manoir, Stanislas, Zaroual, Mehdi, Delpech, Hélène, Fallet, Chloé, Lacroix, Matthieu, Le Cam, Laurent, Theillet, Charles, Sardet, Claude, Rodier, Geneviève

“…E4F1 is essential for early embryonic mouse development and for controlling the balance between proliferation and survival of actively dividing cells. We…”
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Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models by Rabia, Emilia, Garambois, Véronique, Hubert, Julie, Bruciamacchie, Marine, Pirot, Nelly, Delpech, Hélène, Broyon, Morgane, Theillet, Charles, Colombo, Pierre-Emmanuel, Vie, Nadia, Tosi, Diego, Gongora, Celine, Khellaf, Lakhdar, Jarlier, Marta, Radosevic-Robin, Nina, Chardès, Thierry, Pèlegrin, André, Larbouret, Christel

“…Chemoresistance, particularly to gemcitabine, is a major challenge in pancreatic cancer. The epidermal growth factor receptor (EGFR) and human epidermal growth…”
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The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions by Rodier, Geneviève, Kirsh, Olivier, Baraibar, Martín, Houlès, Thibault, Lacroix, Matthieu, Delpech, Hélène, Hatchi, Elodie, Arnould, Stéphanie, Severac, Dany, Dubois, Emeric, Caramel, Julie, Julien, Eric, Friguet, Bertrand, Le Cam, Laurent, Sardet, Claude

“…Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an…”
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E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity by Lacroix, Matthieu, Rodier, Geneviève, Kirsh, Olivier, Houles, Thibault, Delpech, Hélène, Seyran, Berfin, Gayte, Laurie, Casas, Francois, Pessemesse, Laurence, Heuillet, Maud, Bellvert, Floriant, Portais, Jean-Charles, Berthet, Charlene, Bernex, Florence, Brivet, Michele, Boutron, Audrey, Le Cam, Laurent, Sardet, Claude

“…The mitochondrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a central metabolic node that mediates pyruvate oxidation and fuels the tricarboxylic acid…”
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E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis by Goguet-Rubio, Perrine, Seyran, Berfin, Gayte, Laurie, Bernex, Florence, Sutter, Anne, Delpech, Hélène, Linares, Laetitia Karine, Riscal, Romain, Repond, Cendrine, Rodier, Geneviève, Kirsh, Olivier, Touhami, Jawida, Noel, Jean, Vincent, Charles, Pirot, Nelly, Pavlovic, Guillaume, Herault, Yann, Sitbon, Marc, Pellerin, Luc, Sardet, Claude, Lacroix, Matthieu, Le Cam, Laurent

“…The multifunctional protein E4 transcription factor 1 (E4F1) is an essential regulator of epidermal stem cell (ESC) maintenance. Here, we found that E4F1…”
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Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase by Soreze, Yohan, Boutron, Audrey, Habarou, Florence, Barnerias, Christine, Nonnenmacher, Luc, Delpech, Hélène, Mamoune, Asmaa, Chrétien, Dominique, Hubert, Laurence, Bole-Feysot, Christine, Nitschke, Patrick, Correia, Isabelle, Sardet, Claude, Boddaert, Nathalie, Hamel, Yamina, Delahodde, Agnès, Ottolenghi, Chris, de Lonlay, Pascale

“…Synthesis and apoenzyme attachment of lipoic acid have emerged as a new complex metabolic pathway. Mutations in several genes involved in the lipoic acid de…”
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Lung endothelial barrier disruption in Lyl1-deficient mice by Pirot, Nelly, Delpech, Hélène, Deleuze, Virginie, Dohet, Christiane, Courtade-Saïdi, Monique, Basset-Léobon, Céline, Chalhoub, Elias, Mathieu, Danièle, Pinet, Valérie

“…Maturation of newly formed vessels is a multistep phenomenon during which functional endothelial barriers are established. Disruption of vessel integrity is an…”
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Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes by Paul, Conception, Delpech, Hélène, Haouzi, Delphine, Hamamah, Samir, Sardet, Claude, Fabbrizio, Eric

“…Repression of retrotransposons is essential for genome integrity during germ cell development and is tightly controlled through epigenetic mechanisms. In…”
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Leukoencephalopathy with cysts and hyperglycinemia may result from NFU1 deficiency by Nizon, Mathilde, Boutron, Audrey, Boddaert, Nathalie, Slama, Abdelhamid, Delpech, Hélène, Sardet, Claude, Brassier, Anaïs, Habarou, Florence, Delahodde, Agnès, Correia, Isabelle, Ottolenghi, Chris, de Lonlay, Pascale

“…Lipoic acid metabolism defects are new metabolic disorders that cause neurological, cardiomuscular or pulmonary impairment. We report on a patient that…”
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Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition by Arnould, Stéphanie, Rodier, Geneviève, Matar, Gisèle, Vincent, Charles, Pirot, Nelly, Delorme, Yoann, Berthet, Charlène, Buscail, Yoan, Noël, Jean Yohan, Lachambre, Simon, Jarlier, Marta, Bernex, Florence, Delpech, Hélène, Vidalain, Pierre Olivier, Janin, Yves L, Theillet, Charles, Sardet, Claude

“…Reduction in nucleotide pools through the inhibition of mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) has been demonstrated to effectively reduce…”
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Abstract 5190: Correspondence between clinical patient outcome and in vivo carboplatine response of high grade ovarian cancer PDX by du Manoir, Stan P., Delpech, Helene, Orsetti, Beatrice, Tessier, Jeremy, Colombo, Pierre-Emmanuel, Theillet, Charles G.

“…Survival rate for high grade ovarian cancer (HGOC) remains low and has not significantly evolved for several years. This poor outcome is due to several…”
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Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition by Arnould, Stéphanie, Rodier, Geneviève, Matar, Gisèle, Vincent, Charles, Pirot, Nelly, Delorme, Yoann, Berthet, Charlène, Buscail, Yoan, Noël, Jean Yohan, Lachambre, Simon, Jarlier, Marta, Bernex, Florence, Delpech, Hélène, Vidalain, Pierre Olivier, Janin, Yves, Theillet, Charles, Sardet, Claude

“…SUMMARY Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death…”
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The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions by Rodier, Geneviève, Kirsh, Olivier, Baraibar, Martín, Houlès, Thibault, Lacroix, Matthieu, Delpech, Hélène, Hatchi, Elodie, Arnould, Stéphanie, Severac, Dany, Dubois, Emeric, Caramel, Julie, Julien, Eric, Friguet, Bertrand, Le Cam, Laurent, Sardet, Claude

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Mutations in human lipoyltransferase gene LIPT1cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase by Soreze, Yohan, Boutron, Audrey, Habarou, Florence, Barnerias, Christine, Nonnenmacher, Luc, Delpech, Hñlène, Mamoune, Asmaa, Chrñtien, Dominique, Hubert, Laurence, Bole-Feysot, Christine, Nitschke, Patrick, Correia, Isabelle, Sardet, Claude, Boddaert, Nathalie, Hamel, Yamina, Delahodde, Agnès, Ottolenghi, Chris, de Lonlay, Pascale

“…Synthesis and apoenzyme attachment of lipoic acid have emerged as a new complex metabolic pathway. Mutations in several genes involved in the lipoic acid de…”
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Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models by Rabia, Emilia, Garambois, Véronique, Hubert, Julie, Bruciamacchie, Marine, Pirot, Nelly, Delpech, Hélène, Broyon, Morgane, Theillet, Charles, Colombo, Pierre-Emmanuel, Vie, Nadia, Tosi, Diego, Gongora, Celine, Khellaf, Lakhdar, Jarlier, Marta, Radosevic-Robin, Nina, Chardès, Thierry, Pèlegrin, André, Larbouret, Christel

“…Chemoresistance, particularly to gemcitabine, is a major challenge in pancreatic cancer. The epidermal growth factor receptor (EGFR) and human epidermal growth…”
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The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions by Rodier, Geneviéve, Kirsh, Olivier, Baraibar, Martín, Houlés, Thibault, Lacroix, Matthieu, Delpech, Héléne, Hatchi, Elodie, Arnould, Stéphanie, Severac, Dany, Dubois, Emeric, Caramel, Julie, Julien, Eric, Friguet, Bertrand, Cam, Laurent Le, Sardet, Claude

“…Cell Reports, Elsevier, 2015, 11 (2), pp.220-233. \<10.1016/j.celrep.2015.03.024\> Recent data support the notion that a group of key transcriptional…”
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