Search Results - "Delpón, E"

Effects of atorvastatin and simvastatin on atrial plateau currents by Vaquero, M, Caballero, R, Gómez, R, Núñez, L, Tamargo, J, Delpón, E

“…Abstract Recent evidence has shown that the inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) might exert antiarrhythmic effects both…”
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Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers by Valenzuela, C., Delpón, E., Tamkun, M.M., Tamargo, J., Snyders, D.J.

“…Stereoselective drug-channel interactions may help to elucidate the molecular basis of voltage-gated potassium channel block by local anesthetic drugs. We…”
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Regulation of cardiac ion channels by transcription factors: Looking for new opportunities of druggable targets for the treatment of arrhythmias by Crespo-García, T., Cámara-Checa, A., Dago, M., Rubio-Alarcón, M., Rapún, J., Tamargo, J., Delpón, E., Caballero, R.

“…[Display omitted] Cardiac electrical activity is governed by different ion channels that generate action potentials. Acquired or inherited abnormalities in the…”
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Losartan and its metabolite E3174 modify cardiac delayed rectifier K+ currents by CABALLERO, R, DELPON, E, VALENZUELA, C, LONGOBARDO, M, TAMARGO, J

“…The effects of type 1 angiotensin II receptor antagonist losartan and its metabolite E3174 on transmembrane action potentials, hKv1.5, HERG, and I(Ks) currents…”
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Pharmacology of cardiac potassium channels by TAMARGO, Juan, CABALLERO, Ricardo, GOMEZ, Ricardo, VALENZUELA, Carmen, DELPON, Eva

“…Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of K+ ions across the cell membrane along its electrochemical gradient. They…”
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Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization by Caballero, R, Delpón, E, Valenzuela, C, Longobardo, M, González, T, Tamargo, J

“…In the present study, we analyzed the effects of two angiotensin II type 1 receptor antagonists, candesartan (0.1 microM) and eprosartan (1 microM), on hKv1.5,…”
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New investigational drugs for the management of acute heart failure syndromes by Tamargo, J, Amorós, I, Barana, A, Caballero, R, Delpón, E

“…Acute heart failure syndromes (AHFS) enclose a broad spectrum of conditions with different clinical presentations, heart failure history, pathophysiology,…”
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Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH by Longobardo, M, González, T, Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C

“…Bupivacaine‐induced cardiotoxicity increases in hypoxic and acidotic conditions. We have analysed the effects of R(+)bupivacaine on hKv1.5 channels stably…”
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Effects of bupivacaine and a novel local anesthetic, IQB-9302, on human cardiac K+ channels by González, T, Longobardo, M, Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C

“…We have studied and compared the effects of bupivacaine with those induced by a new local anesthetic, IQB-9302, on human cardiac K+ channels hKv1.5, Kv2.1,…”
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Stereoselective effects of the enantiomers of a new local anaesthetic, IQB‐9302, on a human cardiac potassium channel (Kv1.5) by González, T, Longobardo, M, Caballero, R, Delpón, E, Sinisterra, J V, Tamargo, J, Valenzuela, C

“…The N‐substituent of IQB‐9302 has the same number of carbons as bupivacaine, but it exhibits a different spatial localization (n‐butyl vs cyclopropylmethyl)…”
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Effects of propafenone and 5‐hydroxy‐propafenone on hKv1.5 channels by Franqueza, Laura, Valenzuela, Carmen, Delpón, Eva, Longobardo, Mónica, Caballero, Ricardo, Tamargo, Juan

“…1 The goal of this study was to analyse the effects of propafenone and its major metabolite, 5‐hydroxy‐propafenone, on a human cardiac K+ channel (hKv1.5)…”
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Molecular Determinants of Stereoselective Bupivacaine Block of hKv1.5 Channels by Franqueza, Laura, Longobardo, Monica, Vicente, Javier, Delpon, Eva, Tamkun, Michael M, Tamargo, Juan, Snyders, Dirk J, Valenzuela, Carmen

“…Enantiomers of local anesthetics are useful probes of ion channel structure that can reveal three-dimensional relations for drug binding in the channel pore…”
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Effects of rupatadine, a new dual antagonist of histamine and platelet‐activating factor receptors, on human cardiac Kv1.5 channels by Caballero, Ricardo, Valenzuela, Carmen, Longobardo, Mónica, Tamargo, Juan, Delpón, Eva

“…The effects of rupatadine, a new dual antagonist of both histamine H1 and platelet‐activating factor receptors, were studied on human cloned hKv1.5 channels…”
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Block of human cardiac Kv1.5 channels by loratadine : voltage-, time-and use-dependent block at concentrations above therapeutic levels by DELPON, E, VALENZUELA, C, GAY, P, FRANQUEZA, L, SNYDERS, D. J, TAMARGO, J

“…The aim of this study was to analyze the effects of loratadine on a human cardiac K+ channel (hKv1.5) cloned from human ventricle and stably expressed in a…”
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Effects of a quaternary bupivacaine derivative on delayed rectifier K+ currents by Longobardo, M, González, T, Navarro‐Polanco, R, Caballero, R, Delpón, E, Tamargo, J, Snyders, D J, Tamkun, M M, Valenzuela, C

“…Block of hKv1.5 channels by R‐bupivacaine has been attributed to the interaction of the charged form of the drug with an intracellular receptor. However,…”
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Structural determinants of potency and stereoselective block of hKv1.5 channels induced by local anesthetics by Longobardo, M, Delpón, E, Caballero, R, Tamargo, J, Valenzuela, C

“…Block of hKv1.5 channels by bupivacaine is stereoselective, with (R)-(+)-bupivacaine being 7-fold more potent than (S)-(-)-bupivacaine. The study of the…”
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Blockade of cardiac potassium and other channels by antihistamines by DELPON, E, VALENZUELA, C, TAMARGO, J

“…The use of terfenadine and astemizole, two long-acting nonsedating histamine H1 receptor antagonists, has been associated with prolongation of the QT interval,…”
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Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5) by Delpón, E, Caballero, R, Valenzuela, C, Longobardo, M, Snyders, D, Tamargo, J

“…The aim of this study was to analyze the effects of a neutral local anaesthetic, benzocaine, on a cardiac K+ channel cloned from human ventricle. Experiments…”
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Imipramine Blocks Rapidly Activating and Delays Slowly Activating K+ Current Activation in Guinea Pig Ventricular Myocytes by Valenzuela, Carmen, Sainchez-Chapula, Jose, Delpon, Eva, Elizalde, Alejandro, Perez, Onesima, Tamargo, Juan

“…Imipramine is a tricyclic antidepressant drug that also exhibits antiarrhythmic effects and whose clinical spectrum of activity is similar to that of…”
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Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S‐16257‐2 and S‐16260‐2 by Delpón, Eva, Valenzuela, Carmen, Pérez, Onésima, Franqueza, Laura, Gay, Pilar, Snyders, Dirk J., Tamargo, Juan

“…1 The effects of S‐16257‐2 (S57) and S‐16260‐2 (R60), the two enantiomers of a new bradycardic agent, were studied on human cloned K+ channels (hKv1.5) stably…”
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