Search Results - "Delovitch, T L"

Decreased renal ischemia–reperfusion injury by IL-16 inactivation by Wang, S., Diao, H., Guan, Q., Cruikshank, W.W., Delovitch, T.L., Jevnikar, A.M., Du, C.

“…T-cell-mediated renal injury is a major cause of kidney transplant rejection and renal failure; hence, understanding T-cell migration within the kidney is…”
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Structure‐guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non‐obese diabetic mice by Blumenfeld, H. J., Tohn, R., Haeryfar, S. M. M., Liu, Y., Savage, P. B., Delovitch, T. L.

“…Summary Because invariant natural killer T (iNK T) cells link innate and adaptive immunity, the structure‐dependent design of iNK T cell agonists may have…”
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α-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes by Ly, D, Tohn, R, Rubin, B, Blumenfeld, H, Besra, G.S, Veerapen, N, Porcelli, S.A, Delovitch, T.L

“…Protection from type 1 diabetes (T1D), a T helper type 1 (Th1)-mediated disease, is achievable in non-obese diabetic (NOD) mice by treatment with…”
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Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes by Tohn, R, Blumenfeld, H, Haeryfar, S.M.M, Veerapen, N, Besra, G.S, Porcelli, S.A, Delovitch, T.L

“…We have reported previously that treatment of non-obese diabetic (NOD) mice with the invariant natural killer T (iNK T) cell agonist α-galactosylceramide C26:0…”
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Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes by Chen, Wei, Bergerot, Isabelle, Elliott, John F, Harrison, Leonard C, Abiru, Norio, Eisenbarth, George S, Delovitch, Terry L

“…The expression of pro(insulin) in the thymus may lead to the negative selection of pro(insulin) autoreactive T cells and peripheral tolerance to this…”
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Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice by Hill, DJ, Petrik, J, Arany, E, McDonald, TJ, Delovitch, TL

“…Interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) contribute to the initial stages of the autoimmune…”
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Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice by RAPOPORT, M. J, JARAMILLO, A, ZIPRIS, D, LAZARUS, A. H, SERREZE, D. V, LEITER, E. H, CYOPICK, P, DANSKA, J. S, DELOVITCH, T. L

“…Beginning at the time of insulitis (7 wk of age), CD4+ and CD8+ mature thymocytes from nonobese diabetic (NOD) mice exhibit a proliferative unresponsiveness in…”
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Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer by CAMERON, M. J, ARREAZA, G. A, WALDHAUSER, L, GAULDIE, J, DELOVITCH, T. L

“…We have previously shown that systemic injection of multiple low doses of recombinant murine interleukin-4 (mIL-4) can prevent type 1 diabetes (T1D) in…”
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Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells by BERGEROT, I, ARREAZA, G. A, CAMERON, M. J, BURDICK, M. D, STRIETER, R. M, CHENSUE, S. W, CHAKRABARTI, S, DELOVITCH, T. L

“…Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and…”
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Differential Expression of CC Chemokines and the CCR5 Receptor in the Pancreas Is Associated with Progression to Type I Diabetes by Cameron, Mark J, Arreaza, Guillermo A, Grattan, Marsha, Meagher, Craig, Sharif, Shayan, Burdick, Marie D, Strieter, Robert M, Cook, Donald N, Delovitch, Terry L

“…We investigated the biological role of CC chemokines in the Th1-mediated pathogenesis of spontaneous type I diabetes in nonobese diabetic (NOD) mice. Whereas…”
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Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity by Delovitch, Terry L, Wilson, S. Brian

“…Invariant CD1D-restricted natural killer T (iNKT) cells function during innate and adaptive immunity and regulate numerous immune responses, such as autoimmune…”
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The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD by Delovitch, T L, Singh, B

“…Studies of autoimmune diseases in representative animal models have proven to be very informative. This review focuses on the use of one such animal model, the…”
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Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes by Delovitch, Terry L, Bach, Jean-François, Sharif, Shayan, Arreaza, Guillermo A, Zucker, Peter, Mi, Qing-Sheng, Sondhi, Jitin, Naidenko, Olga V, Kronenberg, Mitchell, Koezuka, Yasuhiko, Gombert, Jean-Marc, Leite-de-Moraes, Maria, Gouarin, Christine, Zhu, Ren, Hameg, Agathe, Nakayama, Toshinori, Taniguchi, Masaru, Lepault, Françoise, Lehuen, Agnès, Herbelin, André

“…Type 1 diabetes (T1D) in non-obese diabetic (NOD) mice may be favored by immune dysregulation leading to the hyporesponsiveness of regulatory T cells and…”
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Biolistic-mediated interleukin 4 gene transfer prevents the onset of type 1 diabetes by Cameron, M J, Strathdee, C A, Holmes, K D, Arreaza, G A, Dekaban, G A, Delovitch, T L

“…We tested the efficacy of biolistic-mediated gene transfer as a noninvasive therapy for type 1 diabetes (T1D) in nonobese diabetic (NOD) mice by expression of…”
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T cell autoreactivity to insulin in diabetic and related non-diabetic individuals by Naquet, P, Ellis, J, Tibensky, D, Kenshole, A, Singh, B, Hodges, R, Delovitch, T.L

“…T cell autoreactivity to insulin in type I diabetic and related non-diabetic individuals was analyzed. Peripheral T lymphocytes from both insulin-treated…”
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Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment by CHRISTIE, M. R, BOHRA, G, CHAMPAGNE, P, DANEMAN, D, DELOVITCH, T. L

“…Type 1 diabetes is associated with antibodies that immunoprecipitate a 64-kD islet cell membrane protein from detergent extracts of pancreatic islets. In this…”
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Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes by CHRISTIE, M. R, DANEMAN, D, CHAMPAGNE, P, DELOVITCH, T. L

“…Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. M R Christie , D Daneman , P Champagne and T L Delovitch…”
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Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA‐CW3) by Sodoyer, R., Damotte, M., Delovitch, T.L., Trucy, J., Jordan, B.R., Strachan, T.

“…The HLA‐CW3 gene contained in a cosmid clone identified by transfection expression experiments has been completely sequenced. This provides, for the first…”
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Class I Histocompatibility Antigens and Insulin Receptors: Evidence for Interactions by Phillips, M. Laurie, Moule, Margaret L., Delovitch, Terry L., Yip, Cecil C.

“…We provide evidence for an interaction between mouse class I major histocompatibility complex antigens and insulin receptors. Antibodies against class I but…”
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p21ras and protein kinase C function in distinct and interdependent signaling pathways in C3H 10T1/2 fibroblasts by KROOK, A, RAPOPORT, M. J, ANDERSON, S, PROSS, H, YU CHUN ZHOU, DENHARDT, D. T, DELOVITCH, T. L, HALIOTIS, T

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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