Search Results - "Delorme, Evelyne"

Preclinical Activity of Eltrombopag (SB‐497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist by Erickson‐Miller, Connie L., Delorme, Evelyne, Tian, Shin‐Shay, Hopson, Christopher B., Landis, Amy J., Valoret, Elizabeth I., Sellers, Teresa S., Rosen, Jon, Miller, Stephen G., Luengo, Juan I., Duffy, Kevin J., Jenkins, Julian M.

“…Eltrombopag is a first‐in‐class, orally bioavailable, small‐molecule, nonpeptide agonist of the thrombopoietin receptor (TpoR), which is being developed as a…”
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Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist by Erickson-Miller, Connie L., DeLorme, Evelyne, Tian, Shin-Shay, Hopson, Christopher B., Stark, Kenneth, Giampa, Leslie, Valoret, Elizabeth I., Duffy, Kevin J., Luengo, Juan L., Rosen, Jon, Miller, Stephen G., Dillon, Susan B., Lamb, Peter

“…Peptide and other small molecule agonists have been described for several cytokines and growth factors. Hydrazone compounds described here as thrombopoietin…”
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Structural Requirements for Additional N-Linked Carbohydrate on Recombinant Human Erythropoietin by Elliott, Steve, Chang, David, Delorme, Evelyne, Eris, Tamer, Lorenzini, Tony

“…N-Linked glycosylation is a post-translational event whereby carbohydrates are added to secreted proteins at the consensus sequence Asn-Xaa-Ser/Thr, where Xaa…”
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Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics by Duffy, Kevin J, Shaw, Anthony N, Delorme, Evelyne, Dillon, Susan B, Erickson-Miller, Connie, Giampa, Leslie, Huang, Yifang, Keenan, Richard M, Lamb, Peter, Liu, Nannan, Miller, Stephen G, Price, Alan T, Rosen, Jon, Smith, Heather, Wiggall, Kenneth J, Zhang, Lihua, Luengo, Juan I

“…High-throughput screening has resulted in the discovery of thiosemicarbazone thrombopoietin mimics. A shared pharmacophore hypothesis between this series and a…”
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Mapping of the active site of recombinant human erythropoietin by ELLIOTT, S, LORENZINI, T, CHANG, D, BARZILAY, J, DELORME, E

“…Recombinant human erythropoietin (rHuEPO) variants have been constructed to identify amino acid residues important for biological activity. Immunoassays were…”
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Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics by Duffy, Kevin J, Price, Alan T, Delorme, Evelyne, Dillon, Susan B, Duquenne, Celine, Erickson-Miller, Connie, Giampa, Leslie, Huang, Yifang, Keenan, Richard M, Lamb, Peter, Liu, Nannan, Miller, Stephen G, Rosen, Jon, Shaw, Anthony N, Smith, Heather, Wiggall, Kenneth J, Zhang, Lihua, Luengo, Juan I

“…The invention of a new class of naphtho[1,2-d]imidazole thrombopoietin mimics based on a pharmacophore hypothesis for small-molecule thrombopoietic agonists is…”
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Role of glycosylation on the secretion and biological activity of erythropoietin by Delorme, Evelyne, Lorenzini, Tony, Giffin, James, Martin, Frank, Jacobsen, Frederick, Boone, Tom, Elliott, Steve

“…The erythropoietin (EPO) molecule contains four carbohydrate chains. Three contain N-linkages to asparagines at positions 24, 38, and 83, and one contains an…”
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Structural Requirements for Addition of O-Linked Carbohydrate to Recombinant Erythropoietin by Elliott, Steve, Bartley, Tim, Delorme, Evelyne, Derby, Pat, Hunt, Rob, Lorenzini, Tony, Parker, Vann, Rohde, Michael F, Stoney, Ken

“…To define the structural requirements for addition of O-linked glycosylation in vivo, recombinant erythropoietin (rEPO) variants were constructed. Thirty-three…”
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Discovery of SB-497115, a Small-Molecule Thrombopoietin (TPO) Receptor Agonist for the Treatment of Thrombocytopenia by Luengo, Juan I., Duffy, Kevin J., Shaw, Anthony N., Delorme, Evelyne, Wiggall, Kenneth J., Giampa, Leslie, Liu, Nannan, Smith, Heather, Tian, Shin-Shay, Miller, Stephen G., Keenan, Richard M., Rosen, Jon, Dillon, Susan B., Lamb, Peter, Erickson-Miller, Connie L.

“…Thrombopoietin (TPO) is a 332 amino acid cytokine that plays a key role in the regulation of megakaryopoiesis and platelet production. Over the past 10 years,…”
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Fine-structure epitope mapping of antierythropoietin monoclonal antibodies reveals a model of recombinant human erythropoietin structure by ELLIOTT, S, LORENZINI, T, CHANG, D, BARZILAY, J, DELORME, E, GIFFIN, J, HESTERBERG, L

“…We have isolated and mapped the rHuEPO epitopes for three noncompeting anti-EPO monoclonal antibodies (MoAbs). The MoAb 9G8A recognizes a linear epitope that…”
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Determinants of promoter-specific activity by glucocorticoid receptor by Guido, E C, Delorme, E O, Clemm, D L, Stein, R B, Rosen, J, Miner, J N

“…Glucocorticoid receptor (GR) is expressed at essentially equal levels in almost all tissues and cell types. Remarkably, glucocorticoids themselves regulate…”
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Isolation and characterization of conformation sensitive antierythropoietin monoclonal antibodies : Effect of disulfide bonds and carbohydrate on recombinant human erythropoietin structure by ELLIOTT, S, CHANG, D, DELORME, E, DUNN, C, EGRIE, J, GIFFIN, J, LORENZINI, T, TALBOT, C, HESTERGERG, L

“…We have isolated and characterized three anti-recombinant human erythropoietin (rHuEPO) monoclonal antibodies (MoAbs) that recognize nonoverlapping epitopes on…”
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Incorporation of 3H-gibberellin A20 in roots of G2 peas by Delorme, E.O

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Transfection with Plasmid pSV2gptEJ Induces Chromosome Rearrangements in CHEF Cells by Stenman, Göran, Delorme, Evelyne O., Lau, Ching C., Sager, Ruth

“…In previous cytogenetic studies, trisomy for 3q was found to be the most frequent chromosome change associated with induced tumorigenicity by a variety of…”
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Appositive NP Constructions: We, the Men; We Men; I, a Man; Etc by Delorme, Evelyne, Dougherty, Ray C.

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