Search Results - "Deloch, Lisa"

Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies by Rückert, Michael, Deloch, Lisa, Fietkau, Rainer, Frey, Benjamin, Hecht, Markus, Gaipl, Udo S.

“…Background Radiotherapy (RT) has been known for decades as a local treatment modality for malign and benign disease. In order to efficiently exploit the…”
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The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts by Donaubauer, Anna-Jasmina, Deloch, Lisa, Becker, Ina, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…The bone is a complex organ that is dependent on a tight regulation between bone formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These…”
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Editorial: Osteoarticular-immunological interplay in response to disease and therapy by Deloch, Lisa, Filkova, Maria, Tomcik, Michal

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Clinically Relevant Radiation Exposure Differentially Impacts Forms of Cell Death in Human Cells of the Innate and Adaptive Immune System by Falcke, Sylvia E, Rühle, Paul F, Deloch, Lisa, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…In cancer treatments, especially high-dose radiotherapy (HDRT) is applied. Patients suffering from chronic inflammatory diseases benefit from low-dose…”
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Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and Ongoing Clinical Applications by Derer, Anja, Deloch, Lisa, Rubner, Yvonne, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…Radiotherapy (RT) primarily aims to locally destroy the tumor via the induction of DNA damage in the tumor cells. However, the so-called abscopal, namely…”
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Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells by Wimmer, Sebastian, Deloch, Lisa, Hader, Michael, Derer, Anja, Grottker, Fridolin, Weissmann, Thomas, Hecht, Markus, Gostian, Antoniu-Oreste, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S.

“…While the treatment of squamous cell carcinoma of the head and neck (HNSCC) with radiotherapy (RT) is complemented more and more by immunotherapy in clinical…”
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Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints by Deloch, Lisa, Rückert, Michael, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…Low-dose radiotherapy (LD-RT) for benign inflammatory and/or bone destructive diseases has been used long. Therefore, mechanistic investigations on cells being…”
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Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose by Frey, B., Fietkau, Rainer, Rückert, Michael, Fuchs, Jana, Deloch, Lisa, Gaipl, Udo S.

“…Rheumatoid arthritis (RA) is a multifactorial autoimmune disease whose main hallmark is inflammation and destruction of the joints. Two cell types within the…”
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Deep learning for automatic head and neck lymph node level delineation provides expert-level accuracy by Weissmann, Thomas, Huang, Yixing, Fischer, Stefan, Roesch, Johannes, Mansoorian, Sina, Ayala Gaona, Horacio, Gostian, Antoniu-Oreste, Hecht, Markus, Lettmaier, Sebastian, Deloch, Lisa, Frey, Benjamin, Gaipl, Udo S, Distel, Luitpold Valentin, Maier, Andreas, Iro, Heinrich, Semrau, Sabine, Bert, Christoph, Fietkau, Rainer, Putz, Florian

“…Deep learning-based head and neck lymph node level (HN_LNL) autodelineation is of high relevance to radiotherapy research and clinical treatment planning but…”
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Low-Dose Radiotherapy Ameliorates Advanced Arthritis in hTNF-α tg Mice by Particularly Positively Impacting on Bone Metabolism by Deloch, Lisa, Derer, Anja, Hueber, Axel J, Herrmann, Martin, Schett, Georg Andreas, Wölfelschneider, Jens, Hahn, Jonas, Rühle, Paul-Friedrich, Stillkrieg, Willi, Fuchs, Jana, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…Inflammation and bone erosion are central in rheumatoid arthritis (RA). Even though effective medications for control and treatment of RA are available,…”
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Modulation of the peripheral immune system after low-dose radon spa therapy: Detailed longitudinal immune monitoring of patients within the RAD-ON01 study by Rühle, Paul F., Wunderlich, Roland, Deloch, Lisa, Fournier, Claudia, Maier, Andreas, Klein, Gerhart, Fietkau, Rainer, Gaipl, Udo S., Frey, Benjamin

“…The pain-relieving effects of low-dose radon therapies on patients suffering from chronic painful inflammatory diseases have been described for centuries. Even…”
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Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients by Weissmann, Thomas, Rückert, Michael, Zhou, Jian-Guo, Seeling, Michaela, Lettmaier, Sebastian, Donaubauer, Anna-Jasmina, Nimmerjahn, Falk, Ott, Oliver J, Hecht, Markus, Putz, Florian, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S, Deloch, Lisa

“…Osteoarthritis (OA) is the leading degenerative joint disease in the western world and leads, if left untreated, to a progressive deterioration of joint…”
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Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment by Seitz, Christoph, Rückert, Michael, Deloch, Lisa, Weiss, Eva-Maria, Utz, Sebastian, Izydor, Marika, Ebel, Nina, Schlücker, Eberhard, Fietkau, Rainer, Gaipl, Udo S., Frey, Benjamin

“…Dendritic cell (DC)-based vaccines pulsed with high hydrostatic pressure (HHP)-inactivated tumor cells have been demonstrated to be a promising immunotherapy…”
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Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells by Kulzer, Lorenz, Rubner, Yvonne, Deloch, Lisa, Allgäuer, Andrea, Frey, Benjamin, Fietkau, Rainer, Dörrie, Jan, Schaft, Niels, Gaipl, Udo S

“…Despite the transient immunosuppressive properties of local radiotherapy (RT), this classical treatment modality of solid tumors is capable of inducing…”
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Radon Improves Clinical Response in an Animal Model of Rheumatoid Arthritis Accompanied by Increased Numbers of Peripheral Blood B Cells and Interleukin-5 Concentration by Deloch, Lisa, Hehlgans, Stephanie, Rückert, Michael, Maier, Andreas, Hinrichs, Annika, Flohr, Ann-Sophie, Eckert, Denise, Weissmann, Thomas, Seeling, Michaela, Nimmerjahn, Falk, Fietkau, Rainer, Rödel, Franz, Fournier, Claudia, Frey, Benjamin, Gaipl, Udo S

“…Radon treatment is used as an established therapy option in chronic painful inflammatory diseases. While analgesic effects are well described, little is known…”
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Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation by Deloch, Lisa, Derer, Anja, Hartmann, Josefin, Frey, Benjamin, Fietkau, Rainer, Gaipl, Udo S

“…Even though there is extensive research carried out in radiation oncology, most of the clinical studies focus on the effects of radiation on the local tumor…”
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Immunomodulation by ionizing radiation—impact for design of radio‐immunotherapies and for treatment of inflammatory diseases by Frey, Benjamin, Rückert, Michael, Deloch, Lisa, Rühle, Paul F., Derer, Anja, Fietkau, Rainer, Gaipl, Udo S.

“…Summary Ionizing radiation is often regarded as an element of danger. But, danger responses on the cellular and molecular level are often beneficial with…”
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Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment by Rückert, Michael, Deloch, Lisa, Frey, Benjamin, Schlücker, Eberhard, Fietkau, Rainer, Gaipl, Udo S

“…Radiotherapy (RT) is known to have immune-modulatory properties. We hypothesized that RT and inactivated whole tumor cell vaccines generated with high…”
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The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview by Deloch, Lisa, Rückert, Michael, Weissmann, Thomas, Lettmaier, Sebastian, Titova, Eva, Wolff, Teresa, Weinrich, Felix, Fietkau, Rainer, Gaipl, Udo S

“…Macrophages are a vital part of the innate immune system that are involved in healthy biological processes but also in disease modulation and response to…”
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Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts by Scheper, Julian, Hildebrand, Laura S., Faulhaber, Eva-Maria, Deloch, Lisa, Gaipl, Udo S., Symank, Julia, Fietkau, Rainer, Distel, Luitpold V., Hecht, Markus, Jost, Tina

“…Purpose Despite new treatment options, melanoma continues to have an unfavorable prognosis. DNA damage response (DDR) inhibitors are a promising drug class,…”
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