Toxicity of methyl eugenol against Drosophila melanogaster and its myorelaxant activity in bronchioles isolated from Sus scrofa domesticus

Toxicity of methyl eugenol against Drosophila melanogaster and its myorelaxant activity in bronchioles isolated from Sus scrofa domesticus

This study aimed to evaluate the toxic action of methyl eugenol against Drosophila melanogaster and to evaluate the myorelaxant effect of this constituent on bronchioles isolated from swine from the Sus scrofa domesticus species. The toxicity assay was performed using the fumigation method while myo...

Full description

Saved in:
Bibliographic Details
Published in:Biológia Vol. 76; no. 4; pp. 1275 - 1283
Main Authors: de Souza, Mikael A., Pereira-de-Morais, Luís, Silveira, Zildene de S., Macêdo, Nair S., Araujo, Isaac M., Neto, Luiz J. de L., Delmondes, Gyllyandeson de A., da Costa, Roger H. S., de Oliveira, Lígia C. C., Coutinho, Henrique D. M., Barbosa, Roseli, dos Santos, Hélcio S., da Cunha, Francisco Assis Bezerra
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-04-2021
Springer Nature B.V
Subjects:
Acetylcholine
Biomedical and Life Sciences
Bronchodilators
Cell Biology
Drosophila melanogaster
Eugenol
Evaluation
Fruit flies
Fumigation
Insects
Life Sciences
Methyl eugenol
Microbiology
Original Article
Plant Sciences
Potassium chloride
Sus scrofa domesticus
Swine
Toxicity
Zoology
Myorelaxant
Alternative methods
Toxicity
Methyl eugenol
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to evaluate the toxic action of methyl eugenol against Drosophila melanogaster and to evaluate the myorelaxant effect of this constituent on bronchioles isolated from swine from the Sus scrofa domesticus species. The toxicity assay was performed using the fumigation method while myorelaxant activity was assessed by the administration of increasing and cumulative concentrations (1–1000 μM) to swine bronchial rings under 1 gF tension in an organ bath precontracted with 60 mM potassium chloride (KCl) and 10 μM acetylcholine (ACh). The results showed that methyl eugenol possessed insecticidal action (LC 50 0.116 μg/mL of air). The compound showed a myorelaxant activity over bronchioles (IC 50 of 25.50±14.93 μM and 12.79±9.57 μM for KCl and ACh, respectively). This study serves as starting point for further detailed studies focusing on both the insecticidal and bronchodilatory activity of methyl eugenol.
ISSN:0006-3088
1336-9563
DOI:10.2478/s11756-020-00672-y