Search Results - "Delmas, Bernard"

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals by Thébault, Stéphanie, Lejal, Nathalie, Dogliani, Alexis, Donchet, Amélie, Urvoas, Agathe, Valerio-Lepiniec, Marie, Lavie, Muriel, Baronti, Cécile, Touret, Franck, Da Costa, Bruno, Bourgon, Clara, Fraysse, Audrey, Saint-Albin-Deliot, Audrey, Morel, Jessica, Klonjkowski, Bernard, de Lamballerie, Xavier, Dubuisson, Jean, Roussel, Alain, Minard, Philippe, Le Poder, Sophie, Meunier, Nicolas, Delmas, Bernard

“…The binding of the SARS-CoV-2 spike to angiotensin-converting enzyme 2 (ACE2) promotes virus entry into the cell. Targeting this interaction represents a…”
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Direct electrochemical detection of PB1-F2 protein of influenza A virus in infected cells by Miodek, Anna, Sauriat-Dorizon, Helene, Chevalier, Christophe, Delmas, Bernard, Vidic, Jasmina, Korri-Youssoufi, Hafsa

“…Influenza virus represents a major concern of human health and animal production. PB1-F2 is a small proapoptotic protein supposed to contribute to the…”
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Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core by Bessonne, Mélissa, Morel, Jessica, Nevers, Quentin, Da Costa, Bruno, Ballandras-Colas, Allison, Chenavier, Florian, Grange, Magali, Roussel, Alain, Crépin, Thibaut, Delmas, Bernard

“…Influenza viruses transcribe and replicate their genome in the nucleus of the infected cells, two functions that are supported by the viral RNA-dependent…”
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Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus by LEJAL, Nathalie, TARUS, Bogdan, BOUGUYON, Edwige, CHENAVAS, Sylvie, BERTHO, Nicolas, DELMAS, Bernard, RUIGROK, Rob W. H, DI PRIMO, Carmelo, SLAMA-SCHWOK, Anny

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Amyloid Assemblies of Influenza A Virus PB1-F2 Protein Damage Membrane and Induce Cytotoxicity by Vidic, Jasmina, Richard, Charles-Adrien, Péchoux, Christine, Da Costa, Bruno, Bertho, Nicolas, Mazerat, Sandra, Delmas, Bernard, Chevalier, Christophe

“…PB1-F2 is a small accessory protein encoded by an alternative open reading frame in PB1 segments of most influenza A virus. PB1-F2 is involved in virulence by…”
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The Birnavirus Crystal Structure Reveals Structural Relationships among Icosahedral Viruses by Coulibaly, Fasséli, Chevalier, Christophe, Gutsche, Irina, Pous, Joan, Navaza, Jorge, Bressanelli, Stéphane, Delmas, Bernard, Rey, Félix A.

“…Double-stranded RNA virions are transcriptionally competent icosahedral particles that must translocate across a lipid bilayer to function within the cytoplasm…”
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The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition by Vidy, Aurore, Maisonnasse, Pauline, Da Costa, Bruno, Delmas, Bernard, Chevalier, Christophe, Le Goffic, Ronan

“…The influenza A virus (IAV) PB1-F2 protein is a virulence factor contributing to the pathogenesis observed during IAV infections in mammals. In this study,…”
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Genomic characterization of equine influenza A subtype H3N8 viruses by long read sequencing and functional analyses of the PB1-F2 virulence factor of A/equine/Paris/1/2018 by Kleij, Lena, Bruder, Elise, Raoux-Barbot, Dorothée, Lejal, Nathalie, Nevers, Quentin, Deloizy, Charlotte, Da Costa, Bruno, Legrand, Loïc, Barrey, Eric, Chenal, Alexandre, Pronost, Stéphane, Delmas, Bernard, Dhorne-Pollet, Sophie

“…Equine influenza virus (EIV) remains a threat to horses, despite the availability of vaccines. Strategies to monitor the virus and prevent potential vaccine…”
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Monomeric nucleoprotein of influenza A virus by Chenavas, Sylvie, Estrozi, Leandro F, Slama-Schwok, Anny, Delmas, Bernard, Di Primo, Carmelo, Baudin, Florence, Li, Xinping, Crépin, Thibaut, Ruigrok, Rob W H

“…Isolated influenza A virus nucleoprotein exists in an equilibrium between monomers and trimers. Samples containing only monomers or only trimers can be…”
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Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation by Da Costa, Bruno, Sausset, Alix, Munier, Sandie, Ghounaris, Alexandre, Naffakh, Nadia, Le Goffic, Ronan, Delmas, Bernard

“…The influenza virus RNA-dependent RNA polymerase catalyzes genome replication and transcription within the cell nucleus. Efficient nuclear import and assembly…”
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Antisense oligonucleotides targeting ORF1b block replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Dhorne-Pollet, Sophie, Fitzpatrick, Christopher, Da Costa, Bruno, Bourgon, Clara, Eléouët, Jean-François, Meunier, Nicolas, Burzio, Verónica A., Delmas, Bernard, Barrey, Eric

“…The ongoing COVID-19 pandemic continues to pose a need for new and efficient therapeutic strategies. We explored antisense therapy using oligonucleotides…”
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Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding by Tarus, Bogdan, Chevalier, Christophe, Richard, Charles-Adrien, Delmas, Bernard, Di Primo, Carmelo, Slama-Schwok, Anny

“…The influenza viruses contain a segmented, negative stranded RNA genome. Each RNA segment is covered by multiple copies of the nucleoprotein (NP). X-ray…”
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The Influenza Virus RNA-Polymerase and the Host RNA-Polymerase II: RPB4 Is Targeted by a PB2 Domain That Is Involved in Viral Transcription by Morel, Jessica, Sedano, Laura, Lejal, Nathalie, Da Costa, Bruno, Batsché, Eric, Muchardt, Christian, Delmas, Bernard

“…Influenza virus transcription is catalyzed by the viral RNA-polymerase (FluPol) through a cap-snatching activity. The snatching of the cap of cellular mRNA by…”
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X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking by Swale, Christopher, Da Costa, Bruno, Sedano, Laura, Garzoni, Frédéric, McCarthy, Andrew A., Berger, Imre, Bieniossek, Christoph, Ruigrok, Rob W.H., Delmas, Bernard, Crépin, Thibaut

“…Here, we describe the crystal structures of two distinct isoforms of ligand-free human karyopherin RanBP5 and investigate its global propensity to interact…”
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Codon Deletions in the Influenza A Virus PA Gene Generate Temperature-Sensitive Viruses by Meyer, Léa, Sausset, Alix, Sedano, Laura, Da Costa, Bruno, Le Goffic, Ronan, Delmas, Bernard

“…The influenza virus RNA-dependent RNA polymerase, which is composed of three subunits, PB1, PB2, and PA, catalyzes genome replication and transcription within…”
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Annexin II Incorporated into Influenza Virus Particles Supports Virus Replication by Converting Plasminogen into Plasmin by LEBOUDER, Fanny, MORELLO, Eric, RIMMELZWAAN, Guus F, BOSSE, Francoise, PECHOUX, Christine, DELMAS, Bernard, RITEAU, Béatrice

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Epidemiology, molecular virology and diagnostics of Schmallenberg virus, an emerging orthobunyavirus in Europe by Doceul, Virginie, Lara, Estelle, Sailleau, Corinne, Belbis, Guillaume, Richardson, Jennifer, Bréard, Emmanuel, Viarouge, Cyril, Dominguez, Morgane, Hendrikx, Pascal, Calavas, Didier, Desprat, Alexandra, Languille, Jérôme, Comtet, Loïc, Pourquier, Philippe, Eléouët, Jean-François, Delmas, Bernard, Marianneau, Philippe, Vitour, Damien, Zientara, Stéphan

“…After the unexpected emergence of Bluetongue virus serotype 8 (BTV-8) in northern Europe in 2006, another arbovirus, Schmallenberg virus (SBV), emerged in…”
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Molecular and Structural Bases for the Antigenicity of VP2 of Infectious Bursal Disease Virus by LETZEL, Tobias, COULIBALY, Fasseli, REY, Felix A, DELMAS, Bernard, JAGT, Erik, VAN LOON, Adriaan A. M. W, MUNDT, Egbert

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Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection by Meyer, Léa, Leymarie, Olivier, Chevalier, Christophe, Esnault, Evelyne, Moroldo, Marco, Da Costa, Bruno, Georgeault, Sonia, Roingeard, Philippe, Delmas, Bernard, Quéré, Pascale, Le Goffic, Ronan

“…Avian Influenza virus (AIV) is a major concern for the global poultry industry. Since 2012, several countries have reported AIV outbreaks among domestic…”
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Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection by Leymarie, Olivier, Jouvion, Grégory, Hervé, Pierre-Louis, Chevalier, Christophe, Lorin, Valérie, Lecardonnel, Jérôme, Da Costa, Bruno, Delmas, Bernard, Escriou, Nicolas, Le Goffic, Ronan

“…The PB1-F2 protein encoded by influenza A viruses can contribute to virulence, a feature that is dependent of its sequence polymorphism. Whereas PB1-F2 from…”
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