Search Results - "Dellsén, Anita"

Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor‑1 Agonists by White, Andrew M., Dellsén, Anita, Larsson, Niklas, Kaas, Quentin, Jansen, Frank, Plowright, Alleyn T., Knerr, Laurent, Durek, Thomas, Craik, David J.

“…In this work, cysteine staples were used as a late-stage functionalization strategy to diversify peptides and build conjugates targeting the melanocortin…”
Get full text

Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments by Guéret, Stéphanie M, Thavam, Sasikala, Carbajo, Rodrigo J, Potowski, Marco, Larsson, Niklas, Dahl, Göran, Dellsén, Anita, Grossmann, Tom N, Plowright, Alleyn T, Valeur, Eric, Lemurell, Malin, Waldmann, Herbert

“…“Hot loop” protein segments have variable structure and conformation and contribute crucially to protein–protein interactions. We describe a new hot loop…”
Get full text

Discovery and Early Clinical Development of an Inhibitor of 5‑Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease by Pettersen, Daniel, Broddefalk, Johan, Emtenäs, Hans, Hayes, Martin A, Lemurell, Malin, Swanson, Marianne, Ulander, Johan, Whatling, Carl, Amilon, Carl, Ericsson, Hans, Westin Eriksson, Annika, Granberg, Kenneth, Plowright, Alleyn T, Shamovsky, Igor, Dellsèn, Anita, Sundqvist, Monica, Någård, Mats, Lindstedt, Eva-Lotte

“…5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production of proinflammatory and vasoactive…”
Get full text

Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework by Durek, Thomas, Kaas, Quentin, White, Andrew M, Weidmann, Joachim, Fuaad, Abdullah Ahmad, Cheneval, Olivier, Schroeder, Christina I, de Veer, Simon J, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Plowright, Alleyn T, Craik, David J

“…We have designed a new class of highly potent bivalent melanocortin receptor ligands based on the nature-derived bicyclic peptide sunflower trypsin inhibitor 1…”
Get full text

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor‑1 by Durek, Thomas, Cromm, Philipp M, White, Andrew M, Schroeder, Christina I, Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J, Daly, Norelle L, Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J, Plowright, Alleyn T, Craik, David J

“…Ultrastable cyclic peptide frameworks offer great potential for drug design due to their improved bioavailability compared to their linear analogues. Using the…”
Get full text

Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach by Drowley, Lauren, McPheat, Jane, Nordqvist, Anneli, Peel, Samantha, Karlsson, Ulla, Martinsson, Sofia, Müllers, Erik, Dellsén, Anita, Knight, Sinead, Barrett, Ian, Sánchez, José, Magnusson, Björn, Greber, Boris, Wang, Qing‐Dong, Plowright, Alleyn T.

“…Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling…”
Get full text

Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening by Giordanetto, Fabrizio, Kull, Bengt, Dellsén, Anita

“…The identification of novel class 1 phosphatidylinositide 3-kinases (PI3K) inhibitors by fragment-based virtual screening is described. The discovery of ligand…”
Get full text

Structure‐Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity by Nordqvist, Anneli, O'Mahony, Gavin, Fridén‐Saxin, Maria, Fredenwall, Marlene, Hogner, Anders, Granberg, Kenneth L., Aagaard, Anna, Bäckström, Stefan, Gunnarsson, Anders, Kaminski, Tim, Xue, Yafeng, Dellsén, Anita, Hansson, Eva, Hansson, Pia, Ivarsson, Ida, Karlsson, Ulla, Bamberg, Krister, Hermansson, Majlis, Georgsson, Jennie, Lindmark, Bo, Edman, Karl

“…The mineralocorticoid receptor (MR) is a nuclear hormone receptor involved in the regulation of body fluid and electrolyte homeostasis. In this study we…”
Get full text

RAR-related orphan receptor A isoform 1 (RORa1) is disrupted by a balanced translocation t(4;15)(q22.3;q21.3) associated with severe obesity by KLAR, Joakim, ASLING, Bengt, DAHL, Niklas, CARLSSON, Birgit, ULVSBÄCK, Magnus, DELLSEN, Anita, STRÖM, Carina, RHEDIN, Magdalena, FORSLUND, Anders, ANNEREN, Goran, LUDVIGSSON, Jonas F

“…We have identified a family comprising a mother and two children with idiopathic and profound obesity body mass index (BMI) 41-49 kg/m(2). The three family…”
Get full text

Exploring Binding Mechanisms in Nuclear Hormone Receptors by Monte Carlo and X-ray-derived Motions by Grebner, Christoph, Lecina, Daniel, Gil, Victor, Ulander, Johan, Hansson, Pia, Dellsen, Anita, Tyrchan, Christian, Edman, Karl, Hogner, Anders, Guallar, Victor

“…In this study, we performed an extensive exploration of the ligand entry mechanism for members of the steroid nuclear hormone receptor family (androgen…”
Get full text

Human 4-hydroxyphenylpyruvate dioxygenase : primary structure and chromosomal localization of the gene by RÜETSCHI, U, DELLSEN, A, SAHLIN, P, STENMAN, G, RYMO, L, LINDSTEDT, S

“…We report the primary structure of 4-hydroxyphenylpyruvate dioxygenase [4-hydroxyphenyl-pyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)]. The…”
Get full text

Human 4‐hydroxyphenylpyruvate dioxygenase by RÜETSCHI, Ulla, DELLSÉN, Anita, SAHLIN, Pelle, STENMAN, Göran, RYMO, Lars, LINDSTEDT, Sven

“…We report the primary structure of 4‐hydroxyphenylpyruvate dioxygenase [4‐hydroxyphenylpyruvate: oxygen oxidoreductase (hydroxylating, decarboxylating)]. The…”
Get full text