Search Results - "Dello Stritto, Maria Rosaria"
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DNA topoisomerase 3 is required for efficient germ cell quality control
Published in The Journal of cell biology (07-06-2021)“…An important quality control mechanism eliminates meiocytes that have experienced recombination failure during meiosis. The culling of defective oocytes in…”
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Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex
Published in PLoS genetics (01-07-2021)“…Homologous recombination is a high-fidelity repair pathway for DNA double-strand breaks employed during both mitotic and meiotic cell divisions. Such repair…”
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BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis
Published in PLoS genetics (01-11-2018)“…During meiosis, the maternal and paternal homologous chromosomes must align along their entire length and recombine to achieve faithful segregation in the…”
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The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline
Published in Nucleic acids research (10-06-2022)“…Abstract Homologous recombination is the predominant DNA repair pathway used in the gonad. Of the excess DNA double-strand breaks formed in meiosis, only a…”
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TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans
Published in Nucleic acids research (27-10-2023)“…Abstract Several aspects of telomere biology are regulated by the telomeric repeat-containing RNA TERRA. While TERRA expression is conserved through evolution,…”
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Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
Published in Nature (London) (10-10-2024)“…DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA end resection, a process involving the controlled degradation of the…”
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HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing
Published in Nature communications (10-07-2024)“…The outcome of CRISPR-Cas-mediated genome modifications is dependent on DNA double-strand break (DSB) processing and repair pathway choice. Homology-directed…”
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HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
Published in Molecular cell (22-08-2024)“…G-quadruplexes (G4s) form throughout the genome and influence important cellular processes. Their deregulation can challenge DNA replication fork progression…”
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Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance
Published in PLoS biology (24-03-2016)“…During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous…”
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10
Caenorhabditis elegans RMI2 functional homolog-2 have both overlapping and distinct meiotic functions within the BTR complex
Published in PLoS genetics (12-07-2021)“…Homologous recombination is a high-fidelity repair pathway for DNA double-strand breaks employed during both mitotic and meiotic cell divisions. Such repair…”
Get full text
Journal Article -
11
Caenorhabditis elegans RMI2 functional homolog-2
Published in PLoS genetics (12-07-2021)“…Homologous recombination is a high-fidelity repair pathway for DNA double-strand breaks employed during both mitotic and meiotic cell divisions. Such repair…”
Get full text
Journal Article