Search Results - "Dellinger, Thanh H."
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Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models
Published in Nanomedicine (01-04-2017)“…Abstract Epithelial ovarian cancer (EOC) is the most deadly gynecologic malignancy on account of its late stage at diagnosis and frequency of drug resistant…”
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L1CAM is an independent predictor of poor survival in endometrial cancer — An analysis of The Cancer Genome Atlas (TCGA)
Published in Gynecologic oncology (01-05-2016)“…Abstract Background L1-cell adhesion molecule (L1CAM) was previously reported to carry a poor prognosis in Stage I, low-risk endometrial cancer (EC). We…”
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Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer
Published in Molecular cancer (01-05-2015)“…The EGFR signaling pathway is frequently activated in human ovarian cancer and associated with poor prognosis. However, inhibition of EGFR signaling in…”
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Pterostilbene in Cancer Therapy
Published in Antioxidants (21-03-2021)“…Natural polyphenols are organic chemicals which contain phenol units in their structures and possess antitumor properties. However, a key problem is their…”
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Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer
Published in Molecular cancer therapeutics (01-12-2014)“…JAK/STAT3 is one of the major signaling pathways that is aberrantly activated in ovarian cancer and associated with tumor progression and poor prognosis in…”
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Prognostic significance of B-cells and pSTAT3 in patients with ovarian cancer
Published in PloS one (10-01-2013)“…Several previous studies have identified a strong association between T-cell infiltration and clinical outcome in ovarian cancer. The role of B-cells remains…”
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Gynecologic Organ Preservation or Resection During CRS/HIPEC for GI Cancers
Published in Annals of surgical oncology (05-11-2024)Get full text
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Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer
Published in Molecular therapy. Oncolytics (29-03-2019)“…Oncolytic virotherapy is a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic…”
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HIPEC in the Consolidation Setting: A Consolation Prize for Chemorefractory Ovarian Cancer?
Published in Annals of surgical oncology (01-06-2023)Get full text
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Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target
Published in BMC cancer (10-03-2017)“…Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types,…”
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Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer
Published in Translational oncology (01-08-2019)“…Many signaling pathways, including the JAK/STAT3 pathway, are aberrantly activated and associated with ovarian cancer growth and progression. However,…”
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Role of canonical Wnt signaling in endometrial carcinogenesis
Published in Expert review of anticancer therapy (01-01-2012)“…While the role of Wnt signaling is well established in colorectal carcinogenesis, its function in gynecologic cancers has not been elucidated. Here, we…”
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Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model
Published in Molecular therapy. Oncolytics (25-09-2020)“…Oncolytic virotherapy represents a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the…”
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Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design
Published in Pleura and peritoneum (01-12-2022)“…Peritoneal metastasis (PM) from appendiceal cancer or colorectal cancer (CRC) has significant morbidity and limited survival. Pressurized intraperitoneal…”
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Novel Chimeric Poxvirus CF17 Improves Survival in a Murine Model of Intraperitoneal Ovarian Cancer Metastasis
Published in Molecular therapy. Oncolytics (16-12-2020)“…Despite improvements in surgical techniques and chemotherapy, ovarian cancer remains the most lethal gynecologic cancer. Thus, there is an urgent need for more…”
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ASO Author Reflections: Preventing Nephrotoxicities in Ovarian Cancer Patients Undergoing HIPEC
Published in Annals of surgical oncology (01-12-2023)Get full text
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State of the Science: The role of HIPEC in the treatment of ovarian cancer
Published in Gynecologic oncology (01-02-2021)Get full text
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Impact of PIPAC-Oxaliplatin on Functional Recovery, Good Days, and Survival in a Refractory Colorectal and Appendiceal Carcinomatosis: Secondary Analysis of the US PIPAC Collaborative Phase 1 Trial
Published in Annals of surgical oncology (01-11-2024)“…Background Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a novel, minimally invasive, safe, and repeatable method to treat carcinomatosis…”
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Safety and Efficacy of Oxaliplatin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Colorectal and Appendiceal Cancer with Peritoneal Metastases: Results of a Multicenter Phase I Trial in the USA
Published in Annals of surgical oncology (01-11-2023)“…Background Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a laparoscopic locoregional treatment for peritoneal metastases (PM) from colorectal…”
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