Search Results - "Dellinger, T."

Impaired meningeal lymphatic vessel development worsens stroke outcome by Yanev, Pavel, Poinsatte, Katherine, Hominick, Devon, Khurana, Noor, Zuurbier, Kielen R, Berndt, Marcus, Plautz, Erik J, Dellinger, Michael T, Stowe, Ann M

“…The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to…”
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Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium by Dellinger, Michael T, Brekken, Rolf A

“…There is growing evidence that vascular endothelial growth factor-A (VEGF-A), a ligand of the receptor tyrosine kinases VEGFR1 and VEGFR2, promotes…”
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Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis by Kirane, Amanda, Ludwig, Kathleen F, Sorrelle, Noah, Haaland, Gry, Sandal, Tone, Ranaweera, Renate, Toombs, Jason E, Wang, Miao, Dineen, Sean P, Micklem, David, Dellinger, Michael T, Lorens, James B, Brekken, Rolf A

“…Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used…”
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Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature by Dellinger, Michael T, Meadows, Stryder M, Wynne, Katherine, Cleaver, Ondine, Brekken, Rolf A

“…Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in…”
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Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax by Kanady, John D., Dellinger, Michael T., Munger, Stephanie J., Witte, Marlys H., Simon, Alexander M.

“…Intraluminal valves are required for the proper function of lymphatic collecting vessels and large lymphatic trunks like the thoracic duct. Despite recent…”
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The emergence of targetable MEKanisms in sporadic lymphatic disorders by Dellinger, Michael T, McCormack, Francis X

“…Sporadic lymphatic diseases are orphans among orphans in the medical community, a diverse collection of disorders at the intersection of cardiac,…”
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Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma by AGUILERA, Kristina Y, RIVERA, Lee B, HOON HUR, CARBON, Juliet G, TOOMBS, Jason E, GOLDSTEIN, Courtney D, DELLINGER, Michael T, CASTRILLON, Diego H, BREKKEN, Rolf A

“…There is growing evidence that antiangiogenic therapy stimulates cancer cell invasion and metastasis. However, the underlying molecular mechanisms responsible…”
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Trametinib inhibits lymphatic vessel invasion of bone in a mouse model of Gorham-Stout disease by McCarter, Anna L, Dellinger, Michael T

“…Gorham-Stout disease (GSD) is a rare lymphatic anomaly that can be caused by somatic activating mutations in . This discovery has led investigators to suggest…”
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Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer by Adamson, A W, Ding, Y C, Steele, L, Leong, L A, Morgan, R, Wakabayashi, M T, Han, E S, Dellinger, T H, Lin, P S, Hakim, A A, Wilczynski, S, Warden, C D, Tao, S, Bedell, V, Cristea, M C, Neuhausen, S L

“…High-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and somatic genetic…”
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Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK by Dbouk, Hashem A., Weil, Lauren M., Perera, G. K. Sachith, Dellinger, Michael T., Pearson, Gray, Brekken, Rolf A., Cobb, Melanie H.

“…The with no lysine (K) (WNK) family of enzymes is best known for control of blood pressure through regulation of the function and membrane localization of ion…”
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VEGF-C promotes the development of lymphatics in bone and bone loss by Hominick, Devon, Silva, Asitha, Khurana, Noor, Liu, Ying, Dechow, Paul C, Feng, Jian Q, Pytowski, Bronislaw, Rutkowski, Joseph M, Alitalo, Kari, Dellinger, Michael T

“…Patients with Gorham-Stout disease (GSD) have lymphatic vessels in their bones and their bones gradually disappear. Here, we report that mice that overexpress…”
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KRAS-driven model of Gorham-Stout disease effectively treated with trametinib by Homayun-Sepehr, Nassim, McCarter, Anna L, Helaers, Raphaël, Galant, Christine, Boon, Laurence M, Brouillard, Pascal, Vikkula, Miikka, Dellinger, Michael T

“…Gorham-Stout disease (GSD) is a sporadically occurring lymphatic disorder. Patients with GSD develop ectopic lymphatics in bone, gradually lose bone, and can…”
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Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines by Regan, Erin, Sibley, Robert C, Cenik, Bercin Kutluk, Silva, Asitha, Girard, Luc, Minna, John D, Dellinger, Michael T

“…It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in…”
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Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts by Roland, Christina L, Dineen, Sean P, Lynn, Kristi D, Sullivan, Laura A, Dellinger, Michael T, Sadegh, Leila, Sullivan, James P, Shames, David S, Brekken, Rolf A

“…Vascular endothelial growth factor (VEGF) is a primary stimulant of angiogenesis and is a macrophage chemotactic protein. Inhibition of VEGF is beneficial in…”
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Understanding Student Learning Pathways in Traditional Online History Courses: Utilizing Process Mining Analysis on Clickstream Data by Crosslin, Matt, Breuer, Kimberly, Milikic, Nikola, Dellinger, Justin T

“…Purpose: This study explores ongoing research into self-mapped learning pathways that students utilize to move through a course when given two modalities to…”
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Innovating Teaching Practice Through Professional Learning Communities: Determining Knowledge Sharing and Program Value by Clark, Andrew M., Zhan, Monica, Dellinger, Justin T., Semingson, Peggy L.

“…The Professional Learning Community (PLC) model has been used to help faculty develop innovative teaching practices and diffuse effective strategies and…”
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Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function by Fernandes, Lorenzo M, Tresemer, Jeffrey, Zhang, Jing, Rios, Jonathan J, Scallan, Joshua P, Dellinger, Michael T

“…Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that…”
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Abundance and population structure of Plesionika narval (Fabricius, 1787) in the Northeastern Atlantic by Sousa, R, Pinho, M R, Delgado, J, Pinto, A R, Biscoito, M, Dellinger, T, Henriques, P

“…Analysis of abundance and population structure of Plesionika narval was performed on data concerning 5,255 specimens obtained from 62 fishing sets carried out…”
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Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly by Rodriguez-Laguna, Lara, Agra, Noelia, Ibañez, Kristina, Oliva-Molina, Gloria, Gordo, Gema, Khurana, Noor, Hominick, Devon, Beato, María, Colmenero, Isabel, Herranz, Gonzalo, Torres Canizalez, Juan M, Rodríguez Pena, Rebeca, Vallespín, Elena, Martín-Arenas, Rubén, Del Pozo, Ángela, Villaverde, Cristina, Bustamante, Ana, Ayuso, Carmen, Lapunzina, Pablo, Lopez-Gutierrez, Juan C, Dellinger, Michael T, Martinez-Glez, Victor

“…Generalized lymphatic anomaly (GLA) is a vascular disorder characterized by diffuse or multifocal lymphatic malformations (LMs). The etiology of GLA is poorly…”
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Therapeutic potential of ruxolitinib in human ovarian cancer by Han, E.S, Dellinger, T, Wen, W, Wu, J, Jove, R, Horne, D, Yim, J.H

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