Search Results - "Dellinger, Douglas"

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    Solid-Phase Chemical Synthesis of Phosphonoacetate and Thiophosphonoacetate Oligodeoxynucleotides by Dellinger, Douglas J, Sheehan, David M, Christensen, Nanna K, Lindberg, James G, Caruthers, Marvin H

    Published in Journal of the American Chemical Society (29-01-2003)
    “…Phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides were prepared via a solid-phase synthesis strategy. Under Reformatsky reaction conditions,…”
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    Journal Article
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    An electrospray mass spectrometric method for accurate mass determination of highly acid-sensitive phosphoramidites by Kupihár, Zoltán, Timár, Zoltán, Darula, Zsuzsanna, Dellinger, Douglas J., Caruthers, Marvin H.

    Published in Rapid communications in mass spectrometry (01-01-2008)
    “…An accurate mass determination method utilizing electrospray ionization mass spectrometry is described for analysis of several different types of…”
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    Journal Article
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    Synthesis and Biochemical Evaluation of Phosphonoformate Oligodeoxyribonucleotides by Yamada, Christina M, Dellinger, Douglas J, Caruthers, Marvin H

    Published in Journal of the American Chemical Society (19-04-2006)
    “…Phosphonoformate oligodeoxyribonucleotides were prepared via a solid phase synthesis strategy. The first step in the preparation of appropriate synthons was…”
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    Journal Article
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    Solid-Phase Oligodeoxynucleotide Synthesis:  A Two-Step Cycle Using Peroxy Anion Deprotection by Sierzchala, Agnieszka B, Dellinger, Douglas J, Betley, Jason R, Wyrzykiewicz, Tadeusz K, Yamada, Christina M, Caruthers, Marvin H

    Published in Journal of the American Chemical Society (05-11-2003)
    “…A novel solid-phase phosphoramidite based oligodeoxynucleotide two-step synthesis method has been developed. Keys to this method are replacement of the…”
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    Journal Article
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    Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides by Sheehan, David, Lunstad, Benjamin, Yamada, Christina M., Stell, Brian G., Caruthers, Marvin H., Dellinger, Douglas J.

    Published in Nucleic acids research (15-07-2003)
    “…Phosphorus‐modified phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides were chemically synthesized and their biochemical properties evaluated…”
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    Journal Article
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    Synthesis and Biological Activity of Phosphonocarboxylate DNA by Yamada, Christina M., Dellinger, Douglas J., Caruthers, Marvin H.

    Published in Nucleosides, nucleotides & nucleic acids (01-01-2007)
    “…Oligodeoxynucleotides containing internucleotide phosphonoacetate esters are taken up irreversibly by cells in culture in the absence of cationic lipids. These…”
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    Journal Article
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    Synthesis of DNA using a new two-step cycle by Dellinger, Douglas J, Betley, Jason R, Wyrzykiewicz, Tadeusz K, Caruthers, Marvin H

    “…For the first time a new, two-step method is described for synthesizing deoxyribonucleic acid. The approach uses 5'-carbonate protected…”
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    Journal Article
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    Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells by Hendel, Ayal, Bak, Rasmus O, Clark, Joseph T, Kennedy, Andrew B, Ryan, Daniel E, Roy, Subhadeep, Steinfeld, Israel, Lunstad, Benjamin D, Kaiser, Robert J, Wilkens, Alec B, Bacchetta, Rosa, Tsalenko, Anya, Dellinger, Douglas, Bruhn, Laurakay, Porteus, Matthew H

    Published in Nature biotechnology (01-09-2015)
    “…Improved efficiency of CRISPR/Cas editing with chemically modified synthetic sgRNAs. CRISPR-Cas-mediated genome editing relies on guide RNAs that direct…”
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    Journal Article
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    Oligodeoxyribonucleotide analogs functionalized with phosphonoacetate and thiophosphonoacetate diesters by Dellinger, Douglas J, Yamada, Christina M, Caruthers, Marvin H

    “…Oligodeoxyribonucleotides with phosphonoacetate or thiophosphonoacetate internucleotide linkages can be made in high yield by solid-phase synthesis and possess…”
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    Journal Article
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    Studies on the chemical synthesis of oligoribonucleotides and oligodeoxyribonucleotides by Dellinger, Douglas James

    Published 01-01-1991
    “…Oligoribonucleotides (RNA) as targets for chemical synthesis, present a complex problem for standard protecting group methods. The addition of an extra…”
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    Dissertation