Search Results - "Delle Fratte, Sonia"

Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders by Gianotti, Massimo, Botta, Maurizio, Brough, Stephen, Carletti, Renzo, Castiglioni, Emiliano, Corti, Corrado, Dal-Cin, Michele, Delle Fratte, Sonia, Korajac, Denana, Lovric, Marija, Merlo, Giancarlo, Mesic, Milan, Pavone, Francesca, Piccoli, Laura, Rast, Slavko, Roscic, Maja, Sava, Anna, Smehil, Mario, Stasi, Luigi, Togninelli, Andrea, Wigglesworth, Mark J

“…Histamine H1 and serotonin 5-HT2A receptors mediate two different mechanisms involved in sleep regulation: H1 antagonists are sleep inducers, while 5-HT2A…”
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The identification of novel orally active mGluR5 antagonist GSK2210875 by Pilla, Maria, Andreoli, Michela, Tessari, Michela, Delle-Fratte, Sonia, Roth, Adelheid, Butler, Sharon, Brown, Fiona, Shah, Parita, Bettini, Ezio, Cavallini, Palmina, Benedetti, Roberto, Minick, Doug, Smith, Paul, Tehan, Ben, D’Alessandro, Pier, Lorthioir, Olivier, Ball, Catherine, Garzya, Vincenzo, Goodacre, Caroline, Watson, Stephen

“…The identification of the novel orally active mGluR5 antagonist GSK2210875 is described. This MPEP competitive chemotype was identified via HTS and…”
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Slow dissociation of partial agonists from the D2 receptor is linked to reduced prolactin release by Carboni, Lucia, Negri, Michele, Michielin, Francesca, Bertani, Simone, Fratte, Sonia Delle, Oliosi, Beatrice, Cavanni, Paolo

“…In this study we investigated the correlation between affinity, efficacy, peripheral receptor occupancy, and kinetic properties of D2 dopamine receptor ligands…”
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Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders by GIANOTTI, Massimo, CORTI, Corrado, DELLE FRATTE, Sonia, DI FABIO, Romano, LESLIE, Colin P, PAVONE, Francesca, PICCOLI, Laura, STASI, Luigi, WIGGLESWORTH, Mark J

“…A novel imidazobenzazepine template (5a) with potent dual H(1)/5-HT(2A) antagonist activity was identified. Application of a zwitterionic approach to this…”
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Development of a high-throughput scintillation proximity assay for the identification of C-domain translational initiation factor 2 inhibitors by Delle Fratte, Sonia, Piubelli, Chiara, Domenici, Enrico

“…Translational initiation factor 2 (IF2) is the largest of the 3 factors required for translation initiation in prokaryotes and has been shown to be essential…”
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Purification and properties of serine hydroxymethyltransferase from Sulfolobus solfataricus by Delle Fratte, S, White, R H, Maras, B, Bossa, F, Schirch, V

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Purification and Characterization of Recombinant Rabbit Cytosolic Serine Hydroxymethyltransferase by di Salvo, Martino L., Fratte, Sonia Delle, De Biase, Daniela, Bossa, Francesco, Schirch, Verne

“…A rabbit liver cDNA library in phage λgt10 was screened using the coding cDNA for human cytosolic serine hydroxymethyltransferase. A clone of 1754 bp was…”
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The structure of serine hydroxymethyltransferase as modeled by homology and validated by site‐directed mutagenesis by Pascarella, Stefano, Angelaccio, Sebastiana, Contestabile, Roberto, Fratte, Sonia Delle, Salvo, Martino Di, Bossa, Francesco

“…We describe a model for the three‐dimensional structure of E. coli serine hydroxymethyltransferase based on its sequence homology with other PLP enzymes of…”
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Novel imidazobenzazepine derivatives as dual H 1/5-HT 2A antagonists for the treatment of sleep disorders by Gianotti, Massimo, Corti, Corrado, Fratte, Sonia Delle, Di Fabio, Romano, Leslie, Colin P., Pavone, Francesca, Piccoli, Laura, Stasi, Luigi, Wigglesworth, Mark J.

“…Application of a zwitterionic approach successfully delivered a class of high quality leads, 3-[4-(3-R 1-2-R-5H-imidazo[1,2-…”
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Novel Spirotetracyclic Zwitterionic Dual H 1 /5-HT 2A Receptor Antagonists for the Treatment of Sleep Disorders by Gianotti, Massimo, Botta, Maurizio, Brough, Stephen, Carletti, Renzo, Castiglioni, Emiliano, Corti, Corrado, Dal-Cin, Michele, Delle Fratte, Sonia, Korajac, Denana, Lovric, Marija, Merlo, Giancarlo, Mesic, Milan, Pavone, Francesca, Piccoli, Laura, Rast, Slavko, Roscic, Maja, Sava, Anna, Smehil, Mario, Stasi, Luigi, Togninelli, Andrea, Wigglesworth, Mark J.

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Detection of isoAspartate residues as a posttranslational modification of proteins and peptides by Schirch, Verne, Delle Fratte, Sonia, di Salvo, Martino

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Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders by Gianotti, Massimo, Botta, Maurizio, Brough, Stephen, Carletti, Renzo, Castiglioni, Emiliano, Corti, Corrado, Dal-Cin, Michele, Delle Fratte, Sonia, Korajac, Denana, Lovric, Marija, Merlo, Giancarlo, Mesic, Milan, Pavone, Francesca, Piccoli, Laura, Rast, Slavko, Roscic, Maja, Sava, Anna, Smehil, Mario, Stasi, Luigi, Togninelli, Andrea, Wigglesworth, Mark J

“…Histamine H(1) and serotonin 5-HT(2A) receptors mediate two different mechanisms involved in sleep regulation: H(1) antagonists are sleep inducers, while…”
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Deamidation of Asparagine Residues in a Recombinant Serine Hydroxymethyltransferase by di Salvo, Martino L., Delle Fratte, Sonia, Maras, Bruno, Bossa, Francesco, Wright, H.Tonie, Schirch, Verne

“…Serine hydroxymethyltransferase purified from rabbit liver cytosol has at least two Asn residues (Asn5 and Asn220) that are 67 and 30% deamidated,…”
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Function of the active-site lysine in Escherichia coli serine hydroxymethyltransferase by SCHIRCH, D, DELL FRATTE, S, IURESCIA, S, ANGELACCIO, S, CONTESTABILE, R, BOSSA, F, SCHIRCH, V

“…Serine hydroxymethyltransferase has a conserved lysine residue (Lys-229) that forms the internal aldimine with pyridoxal 5'-phosphate. In other pyridoxal…”
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Determination of Serine Hydroxymethyltransferase and Reduced Folate Pools in Tissue Extracts by Kim, Dong Woon, Fratte, Sonia Delle, Jeong, Soon-Seog, Schirch, Verne

“…Serine hydroxymethyltransferase (SHMT) from all sources tested catalyzes the slow exchange of thepro-2S proton of glycine with solvent protons. In the presence…”
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Site-directed mutagenesis techniques in the study of Escherichia coli serine hydroxymethyltransferase by Iurescia, S, Condò, I, Angelaccio, S, Delle Fratte, S, Bossa, F

“…The 3340-bp fragment containing the Escherichia coli glyA gene coding for serine hydroxymethyltransferase was reduced in size by PCR, and the 1600-bp fragment…”
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Site-Directed Mutagenesis Techniques in the Study ofEscherichia coliSerine Hydroxymethyltransferase by Iurescia, Sandra, Condò, Ivano, Angelaccio, Sebastiana, Fratte, Sonia Delle, Bossa, Francesco

“…The 3340-bp fragment containing theEscherichia coli glyA gene coding for serine hydroxymethyltransferase was reduced in size by PCR, and the 1600-bp fragment…”
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The Function of Arginine 363 as the Substrate carboxyl‐binding Site in Escherichia coli Serine Hydroxymethyltransferase by Fratte, Sonia Delle, Iurescia, Sandra, Angelaccio, Sebastiana, Bossa, Francesco, Schirch, Verne

“…Both the highly conserved Arg363 and Arg372 residues of Escherichia coli serine hydroxymethyltransferase were changed to alanine and lysine residues. Each of…”
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Serine hydroxymethyltransferase: role of the active site lysine in the mechanism of the enzyme by Schirch, D, Delle Fratte, S, Iurescia, S, Angelaccio, S, Contestabile, R, Bossa, F, Schirch, V

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