Search Results - "Della Pasqua, O. E."

Pharmacokinetic–pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors by Huntjens, D. R. H., Danhof, M., Della Pasqua, O. E.

“…The mechanism by which COX inhibitors exert their analgesic effect is well established. However, data show no direct correlation between drug concentrations in…”
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The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery by Ackaert, O.W., De Graan, J., Capancioni, R., Della Pasqua, O.E., Dijkstra, D., Westerink, B.H., Danhof, M., Bouwstra, J.A.

“…The feasibility of transdermal iontophoretic transport of 4 novel ester prodrugs of 5-OH-DPAT (glycine-, proline-, valine- and β-alanine-5-OH-DPAT) was…”
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Prediction of headache response in migraine treatment by Maas, H J, Danhof, M, Della Pasqua, O E

“…Triptans are efficacious for the acute treatment of migraine attacks. Yet, defining a concentration-effect relation for these compounds is difficult as the…”
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Analysis of the relationship between age and treatment response in migraine by Maas, H J, Danhof, M, Della Pasqua, O E

“…In migraine, headache severity varies with age. As a consequence, the effectiveness of medication may also depend on a patient's age. The purpose of this study…”
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Pharmacokinetic‐pharmacodynamic modelling in the early development phase of anti‐psychotics: a comparison of the effects of clozapine, S 16924 and S 18327 in the EEG model in rats by Parker, T J, Della Pasqua, O E, Loizillon, E, Chezaubernard, C, Jochemsen, R, Danhof, M

“…The use of pharmacokinetic/pharmacodynamic (PK/PD) analysis in early compound development was investigated in the rat for two developmental anti‐psychotic…”
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Oc020—Optimal Sampling Strategy For Busulfan In Stem Cell Transplantation Patients by Castro, F.A, Piana, C, Lanchote, V.L, Simões, B.P, Della Pasqua, O.E

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Establishing in vitro to clinical correlations in the evaluation of cardiovascular safety pharmacology by Chain, A.S.Y., Sturkenboom, M.C.J.M., Danhof, M., Pasqua, O.E. Della

“…Preclinical studies are vital in establishing the efficacy and safety of a new chemical entity (NCE) in humans. To deliver meaningful information, experiments…”
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Markers of disease severity in chronic obstructive pulmonary disease by Franciosi, Luigi G., Page, Clive P., Celli, Bartolome R., Cazzola, Mario, Walker, Michael J., Danhof, Meindert, Rabe, Klaus F., Pasqua, Oscar E. Della

“…Diagnosis and assessment of treatment effect in chronic obstructive pulmonary disease (COPD) have relied primarily on the examination of a complex set of…”
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