Pregnancy management in Behçet's disease treated with uninterrupted infliximab. Report of a case with fetal growth restriction and mini-review of the literature

The mutual impact of Behçet's disease (BD) and pregnancy is variable and still unclear. Among the safe drugs administered, the newer infliximab (IFX) was rarely experienced in pregnancy, particularly in the third trimester. The authors report a pregnancy with fetal growth restriction at 36 week...

Full description

Saved in:

Bibliographic Details
Published in:	Clinical and experimental obstetrics & gynecology Vol. 41; no. 2; pp. 205 - 207
Main Authors:	Mainini, G, Di Donna, M C, Esposito, E, Ercolano, S, Correa, R, Stradella, L, Della Gala, A, De Franciscis, P
Format:	Journal Article
Language:	English
Published:	Canada 01-01-2014
Subjects:	Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antibodies, Monoclonal - therapeutic use Anticoagulants - therapeutic use Behcet Syndrome - drug therapy Enoxaparin - therapeutic use Female Fetal Growth Retardation - drug therapy Humans Infant, Newborn Infliximab Labor, Induced Male Pregnancy Pregnancy Complications - drug therapy Pregnancy Trimester, Third
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The mutual impact of Behçet's disease (BD) and pregnancy is variable and still unclear. Among the safe drugs administered, the newer infliximab (IFX) was rarely experienced in pregnancy, particularly in the third trimester. The authors report a pregnancy with fetal growth restriction at 36 weeks in a 31-year-old primigravida with symptomatic BD, treated with uninterrupted monthly IFX and daily enoxaparin. The patient was induced at 38 weeks and had an uneventful vaginal delivery of a healthy baby. The postpartum period and following six months were uneventful for mother in terms of BD exacerbation, and newborn in terms of potential risks of neonatal BD and/or infections due to late immunosuppressive IFX administration. Because of the inconstant mutual impact, BD pregnancies should be precautionary considered at "potential high-risk" and need a careful and close monitoring by a multidisciplinary team with specific expertise.
Bibliography:	ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4
ISSN:	0390-6663
DOI:	10.12891/ceog17642014