Search Results - "Delk, Nikki A."

A microphysiological system reveals neutrophil contact-dependent attenuation of pancreatic tumor progression by CXCR2 inhibition-based immunotherapy by Shao, Shuai, Delk, Nikki A., Jones, Caroline N.

“…Cancer cells recruit neutrophils from the bloodstream into the tumor tissue, where these immune cells promote the progression of numerous solid tumors. Studies…”
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Interleukin-1 and Nuclear Factor Kappa B Signaling Promote Breast Cancer Progression and Treatment Resistance by Diep, Sydney, Maddukuri, Mahita, Yamauchi, Stephanie, Geshow, Ganamee, Delk, Nikki A

“…While meant for wound healing and immunity in response to injury and infection, inflammatory signaling is usurped by cancerous tumors to promote disease…”
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Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence by Dahl, Haley C, Kanchwala, Mohammed, Thomas-Jardin, Shayna E, Sandhu, Amrit, Kanumuri, Preethi, Nawas, Afshan F, Xing, Chao, Lin, Chenchu, Frigo, Daniel E, Delk, Nikki A

“…Chronic inflammation promotes prostate cancer (PCa) initiation and progression. We previously reported that acute intereluekin-1 (IL-1) exposure represses…”
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Calmodulin‐related CML24 interacts with ATG4b and affects autophagy progression in Arabidopsis by Tsai, Yu‐Chang, Koo, Yeonjong, Delk, Nikkí A, Gehl, Bernadette, Braam, Janet

“…Plants encounter environmental stress challenges that are distinct from those of other eukaryotes because of their relative immobility. Therefore, plants may…”
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Interleukin-6: A bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells by Delk, Nikki A., Farach-Carson, Mary C.

“…Autophagy reallocates nutrients and clears normal cells of damaged proteins and organelles. In the context of metastatic disease, invading cancer cells hijack…”
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Neuronal Trans-Differentiation in Prostate Cancer Cells by Farach, Andrew, Ding, Yi, Lee, MinJae, Creighton, Chad, Delk, Nikki A., Ittmann, Michael, Miles, Brian, Rowley, David, Farach-Carson, Mary C., Ayala, Gustavo E.

“…BACKGROUND Neuroendocrine (NE) differentiation in prostate cancer (PCa) is an aggressive phenotype associated with therapy resistance. The complete phenotype…”
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IL-1-conferred gene expression pattern in ERα + BCa and AR + PCa cells is intrinsic to ERα - BCa and AR - PCa cells and promotes cell survival by Nawas, Afshan F, Kanchwala, Mohammed, Thomas-Jardin, Shayna E, Dahl, Haley, Daescu, Kelly, Bautista, Monica, Anunobi, Vanessa, Wong, Ally, Meade, Rachel, Mistry, Ragini, Ghatwai, Nisha, Bayerl, Felix, Xing, Chao, Delk, Nikki A

“…Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or…”
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p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines by Chang, Megan A., Morgado, Micaela, Warren, Curtis R., Hinton, Cimona V., Farach-Carson, Mary C., Delk, Nikki A.

“…BACKGROUND Bone marrow stromal cell (BMSC) paracrine factor(s) can induce apoptosis in bone metastatic prostate cancer (PCa) cell lines. However, the PCa cells…”
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Arabidopsis Potential Calcium Sensors Regulate Nitric Oxide Levels and the Transition to Flowering by Tsai, Yu-Chang, Delk, Nikkí A., Chowdhury, Naweed I., Braam, Janet

“…In plants, flowering is a critical developmental transition orchestrated by four regulatory pathways. Distinct alleles encoding mutant forms of the Arabidopsis…”
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NF-κB signaling promotes castration-resistant prostate cancer initiation and progression by Thomas-Jardin, Shayna E., Dahl, Haley, Nawas, Afshan F., Bautista, Monica, Delk, Nikki A.

“…Prostate Cancer (PCa) is the second leading cause of cancer-related death in men. Adenocarcinoma of the prostate is primarily composed of Androgen…”
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The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts by Wagner, Daniel S, Delk, Nikki A, Lukianova-Hleb, Ekaterina Y, Hafner, Jason H, Farach-Carson, Mary C, Lapotko, Dmitri O

“…Abstract Cell theranostics is a new approach that unites diagnosis, therapy and confirmation (guidance) of the results of therapy in one single process at cell…”
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RELA is sufficient to mediate interleukin‐1 repression of androgen receptor expression and activity in an LNCaP disease progression model by Thomas‐Jardin, Shayna E., Dahl, Haley, Kanchwala, Mohammed S., Ha, Freedom, Jacob, Joan, Soundharrajan, Reshma, Bautista, Monica, Nawas, Afshan F., Robichaux, Dexter, Mistry, Ragini, Anunobi, Vanessa, Xing, Chao, Delk, Nikki A.

“…Background The androgen receptor (AR) nuclear transcription factor is a therapeutic target for prostate cancer (PCa). Unfortunately, patients can develop…”
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Identification of an IL‐1‐induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR− PCa cells by Thomas‐Jardin, Shayna E., Kanchwala, Mohammed S., Jacob, Joan, Merchant, Sana, Meade, Rachel K., Gahnim, Nagham M., Nawas, Afshan F., Xing, Chao, Delk, Nikki A.

“…Background In immunosurveillance, bone‐derived immune cells infiltrate the tumor and secrete inflammatory cytokines to destroy cancer cells. However, cancer…”
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CML24, Regulated in Expression by Diverse Stimuli, Encodes a Potential Ca²⁺ Sensor That Functions in Responses to Abscisic Acid, Daylength, and Ion Stress by Delk, Nikkí A, Johnson, Keith A, Chowdhury, Naweed I, Braam, Janet

“…Changes in intracellular calcium (Ca²⁺) levels serve to signal responses to diverse stimuli. Ca²⁺ signals are likely perceived through proteins that bind Ca²⁺,…”
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Altered Subcellular Localization of Tumor-Specific Cyclin E Isoforms Affects Cyclin-Dependent Kinase 2 Complex Formation and Proteasomal Regulation by DELK, Nikki A, HUNT, Kelly K, KEYOMARSI, Khandan

“…In tumors, alternative translation and posttranslational proteolytic cleavage of full-length cyclin E (EL) produces tumorigenic low molecular weight cyclin E…”
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IL-1β Induces p62/SQSTM1 and Represses Androgen Receptor Expression in Prostate Cancer Cells by Chang, M.A., Patel, V., Gwede, M., Morgado, M., Tomasevich, K., Fong, E.L., Farach-Carson, M.C., Delk, Nikki A.

“…ABSTRACT Chronic inflammation is associated with advanced prostate cancer (PCa), although the mechanisms governing inflammation‐mediated PCa progression are…”
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Abstract 287: Novel p62 interaction suggests novel role in glutamate metabolism by Dahl, Haley Christine, Konakalla, Anisha R., Kanumuri, Preethi, Mansoor, Basir, Kelley, Anastasia, Shipurkar, Riya, Delk, Nikki A.

“…Prostate cancer (PCa) is the second most common cause of cancer-related death among American men. Androgen Receptor (AR) transcriptional activity is required…”
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Abstract 3776: Bone marrow stromal cell paracrine signaling and IL-6 induce autophagy in bone metastatic prostate cancer cells by Delk, Nikki A., Farach-Carson, Mary C.

“…Prostate cancer (PCa) is the second leading cause of death in North American men, where 80% of PCa mortality is due to bone metastasis. It is imperative to…”
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IL-1[beta] Induces p62/SQSTM1 and Represses Androgen Receptor Expression in Prostate Cancer Cells by Chang, MA, Patel, V, Gwede, M, Morgado, M, Tomasevich, K, Fong, EL, Farach-Carson, MC, Delk, Nikki A

“…Chronic inflammation is associated with advanced prostate cancer (PCa), although the mechanisms governing inflammation-mediated PCa progression are not fully…”
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Abstract 4839: Mechanistic regulation of autophagy in the prostate cancer-bone marrow stromal microenvironment by Delk, Nikki A., Diaz, Ariel L., Farach-Carson, Mary C.

“…Autophagy is the process of intracellular digestion to reallocate nutrients and clear cells of damaged proteins and organelles. Normally, autophagy maintains…”
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