Search Results - "Delisle, R K"

The different strategies for designing GPCR and kinase targeted libraries by Lowrie, J F, Delisle, R K, Hobbs, D W, Diller, D J

“…In recent years the trend in combinatorial library design has shifted to include target class focusing along with diversity and drug-likeness criteria. In this…”
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Interaction of Organophosphate Pesticides and Related Compounds with the Androgen Receptor by Tamura, Hiroto, Yoshikawa, Hiromichi, Gaido, Kevin W., Ross, Susan M., DeLisle, Robert K., Welsh, William J., Richard, Ann M.

“…Identification of several environmental chemicals capable of binding to the androgen receptor (AR) and interfering with its normal function has heightened…”
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The Vitamin D Receptor Interacts with General Transcription Factor IIB (∗) by MacDonald, Paul N., Sherman, David R., Dowd, Diane R., Jefcoat, Stephen C., DeLisle, Robert K.

“…The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is…”
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Computational Models for Predicting the Binding Affinities of Ligands for the Wild-Type Androgen Receptor and a Mutated Variant Associated with Human Prostate Cancer by Ai, Ni, DeLisle, Robert K, Yu, Seong Jae, Welsh, William J

“…In the present study, values of the binding energy (BE) were calculated for the rat androgen receptor on a data set of 25 steroidal and nonsteroidal compounds…”
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The Autonomous Transactivation Domain in Helix H3 of the Vitamin D Receptor Is Required For Transactivation and Coactivator Interaction by Kraichely, Dennis M., Collins, John J., DeLisle, Robert K., MacDonald, Paul N.

“…A ligand-inducible transactivation function (AF-2) exists in the extreme carboxyl terminus of the vitamin D receptor (VDR) that is essential for…”
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Homology modeling of the estrogen receptor subtype β (ER-β) and calculation of ligand binding affinities by DeLisle, Robert K., Yu, Seong-Jae, Nair, Anil C., Welsh, William J.

“…Estrogen is a steroid hormone playing critical roles in physiological processes such as sexual differentiation and development, female and male reproductive…”
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Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib by Williams, Stephen A, Murthy, Ashwin C, DeLisle, Robert K, Hyde, Craig, Malarstig, Anders, Ostroff, Rachel, Weiss, Sophie J, Segal, Mark R, Ganz, Peter

“…BACKGROUND:Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug…”
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Trauma-induced neurotoxicity in rat hippocampal neurons by Yoon, K W, Mitchell, H L, Broder, L D, Brooker, R W, Delisle, R K

“…We have previously shown that traumatic injury of hippocampal cells triggers release of a soluble neurotoxin that can be transferred to an uninjured culture…”
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Elucidation of the Na super(+), K super(+)-ATPase digitalis binding site by Keenan, S M, DeLisle, R K, Welsh, W J, Paula, S, Ball, W J

“…Despite controversy over their use and the potential for toxic side effects, cardiac glycosides have remained an important clinical component for the treatment…”
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Induction of Decision Trees via Evolutionary Programming by DeLisle, Robert Kirk, Dixon, Steven L

“…Decision trees have been used extensively in cheminformatics for modeling various biochemical endpoints including receptor−ligand binding, ADME properties,…”
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Fast Small Molecule Similarity Searching with Multiple Alignment Profiles of Molecules Represented in One-Dimension by Wang, Norman, DeLisle, Robert K, Diller, David J

“…Multiple sequence alignment has proven to be a powerful method for creating protein and DNA sequence alignment profiles. These profiles of protein families are…”
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Elucidation of the Na +, K +-ATPase digitalis binding site by Keenan, Susan M., DeLisle, Robert K., Welsh, William J., Paula, Stefan, Ball, William J.

“…Despite controversy over their use and the potential for toxic side effects, cardiac glycosides have remained an important clinical component for the treatment…”
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Trauma-induced neurotoxicity in rat hippocampal neurons. Editorial comment by KONG-WOO YOON, MITCHELL, H. L, BRODER, L. D, BROOKER, R. W, DELISLE, R. K, DAWSON, T. M

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P41: Nutrition Education Program Improves Students' Food Choices in 10 Lessons by Massey, S., MPH, RD, Delisle, K., MHSc, RD, Sawchuk, L., MPE, RD, Mercer, W., PhD, Zahr, R., BSc, RD

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