Search Results - "Delgado Lagos, Fredy"
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Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation
Published in Redox biology (01-06-2023)“…Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether…”
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Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis
Published in International journal of molecular sciences (19-06-2019)“…The AMP-activated protein kinase (AMPK) is an energy sensing kinase that is activated by a drop in cellular ATP levels. Although several studies have addressed…”
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Effect of Thrombin on the Metabolism and Function of Murine Macrophages
Published in Cells (Basel, Switzerland) (23-05-2022)“…Macrophages are plastic and heterogeneous immune cells that adapt pro- or anti-inflammatory phenotypes upon exposure to different stimuli. Even though there…”
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Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function
Published in Circulation (New York, N.Y.) (02-03-2021)“…In vascular endothelial cells, cysteine metabolism by the cystathionine γ lyase (CSE), generates hydrogen sulfide-related sulfane sulfur compounds (H S ), that…”
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Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes
Published in Blood (25-03-2021)“…Secreted modular calcium-binding protein 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by microRNA-223…”
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A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling
Published in iScience (18-10-2024)“…Fatty acid metabolites, produced by cytochrome P450 enzymes and soluble epoxide hydrolase (sEH), regulate inflammation. Here, we report that the transforming…”
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Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function
Published in Circulation (New York, N.Y.) (08-02-2021)Get full text
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