Search Results - "Delgado, Cássia Pereira"
-
1
In silico Studies on the Interaction between Mpro and PLpro From SARS‐CoV‐2 and Ebselen, its Metabolites and Derivatives
Published in Molecular informatics (01-08-2021)“…The COVID‐19 pandemic caused by the SARS‐CoV‐2 has mobilized scientific attention in search of a treatment. The cysteine‐proteases, main protease (Mpro) and…”
Get full text
Journal Article -
2
Reactivity and binding mode of disulfiram, its metabolites, and derivatives in SARS-CoV-2 PLpro: insights from computational chemistry studies
Published in Journal of molecular modeling (2022)“…The papain-like protease (PL pro ) from SARS-CoV-2 is an important target for the development of antivirals against COVID-19. The safe drug disulfiram (DSF)…”
Get full text
Journal Article -
3
In silico analysis of the antidepressant fluoxetine and similar drugs as inhibitors of the human protein acid sphingomyelinase: a related SARS-CoV-2 inhibition pathway
Published in Journal of biomolecular structure & dynamics (24-11-2023)“…Acid Sphingomyelinase (ASM) is a human phosphodiesterase that catalyzes the metabolism of sphingomyelin (SM) to ceramide and phosphocholine. ASM is involved in…”
Get full text
Journal Article -
4
In silico studies of Mpro and PLpro from SARS-CoV-2 and a new class of cephalosporin drugs containing 1,2,4-thiadiazole
Published in Structural chemistry (01-12-2022)“…The SARS-CoV-2 proteases M pro and PL pro are important targets for the development of antivirals against COVID-19. The functional group 1,2,4-thiadiazole has…”
Get full text
Journal Article -
5
In Silico Analysis of the Antidepressant Fluoxetine and Related Drugs at SARS-CoV-2 Main Protease (M pro ) and Papain-like Protease (PL pro )
Published in Current drug discovery technologies (01-03-2023)“…SARS-CoV-2 main protease (M or 3CL ) and papain-like protease (PL ) are common viral targets for repurposed drugs to combat COVID-19 disease. Recently, several…”
Get more information
Journal Article -
6
Acid sphingomyelinase (ASM) and COVID‐19: A review of the potential use of ASM inhibitors against SARS‐CoV‐2
Published in Cell biochemistry and function (01-04-2023)“…In the last 2 years, different pharmacological agents have been indicated as potential inhibitors of SARS‐CoV‐2 in vitro. Specifically, drugs termed as…”
Get full text
Journal Article -
7
In silico studies of M.sup.pro and PL.sup.pro from SARS-CoV-2 and a new class of cephalosporin drugs containing 1,2,4-thiadiazole
Published in Structural chemistry (01-12-2022)“…The SARS-CoV-2 proteases M.sup.pro and PL.sup.pro are important targets for the development of antivirals against COVID-19. The functional group…”
Get full text
Journal Article -
8
In silico Studies on the Interaction between Mpro and PLpro From SARS‐CoV‐2and Ebselen, its Metabolites and Derivatives
Published in Molecular informatics (01-08-2021)“…The COVID‐19 pandemic caused by the SARS‐CoV‐2 has mobilized scientific attention in search of a treatment. The cysteine‐proteases, main protease (Mpro) and…”
Get full text
Journal Article -
9
Reactivity and binding mode of disulfiram, its metabolites, and derivatives in SARS-CoV-2 PL pro : insights from computational chemistry studies
Published in Journal of molecular modeling (12-10-2022)“…The papain-like protease (PL ) from SARS-CoV-2 is an important target for the development of antivirals against COVID-19. The safe drug disulfiram (DSF)…”
Get full text
Journal Article