Search Results - "Deleo, R."

Waves of resistance: Staphylococcus aureus in the antibiotic era by Chambers, Henry F, DeLeo, Frank R

“…Key Points Staphylococcus aureus is notorious for its ability to become resistant to antibiotics. Antibiotic resistance in this organism has occurred in…”
Get full text

Neutrophils and Bacterial Immune Evasion by Kobayashi, Scott D., Malachowa, Natalia, DeLeo, Frank R.

“…Neutrophils are an important component of the innate immune system and provide a front line of defense against bacterial infection. Although most bacteria are…”
Get full text

Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era by DeLeo, Frank R, Chambers, Henry F

“…Staphylococcus aureus is the leading cause of bacterial infections in developed countries and produces a wide spectrum of diseases, ranging from minor skin…”
Get full text

Community-associated meticillin-resistant Staphylococcus aureus by DeLeo, Frank R, Dr, Otto, Michael, PhD, Kreiswirth, Barry N, Prof, Chambers, Henry F, Prof

“…Summary Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality…”
Get full text

Neutrophils in innate host defense against Staphylococcus aureus infections by Rigby, Kevin M., DeLeo, Frank R.

“…Staphylococcus aureus has been an important human pathogen throughout history and is currently a leading cause of bacterial infections worldwide. S. aureus has…”
Get full text

Targeting of Alpha-Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model by Kennedy, Adam D., Wardenburg, Juliane Bubeck, Gardner, Donald J., Long, Daniel, Whitney, Adeline R., Braughton, Kevin R., Schneewind, Olaf, DeLeo, Frank R.

“…Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are predominantly those affecting skin and soft tissues. Although…”
Get full text

Neutrophil apoptosis and the resolution of infection by Kennedy, Adam D., DeLeo, Frank R.

“…Polymorphonuclear leukocytes (PMNs) are the most abundant white cell in humans and an essential component of the innate immune system. PMNs are typically the…”
Get full text

Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae by DeLeo, Frank R., Chen, Liang, Porcella, Stephen F., Martens, Craig A., Kobayashi, Scott D., Porter, Adeline R., Chavda, Kalyan D., Jacobs, Michael R., Mathema, Barun, Olsen, Randall J., Bonomo, Robert A., Musser, James M., Kreiswirth, Barry N.

“…Infections caused by drug-resistant bacteria are a major problem worldwide. Carbapenem-resistant Klebsiella pneumoniae , most notably isolates classified as…”
Get full text

Epidemic Klebsiella pneumoniae ST258 is a hybrid strain by Chen, Liang, Mathema, Barun, Pitout, Johann D D, DeLeo, Frank R, Kreiswirth, Barry N

“…Carbapenem-resistant Enterobacteriaceae (CRE), especially Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae, pose an urgent threat in health…”
Get full text

Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis by Greenlee-Wacker, Mallary C, Rigby, Kevin M, Kobayashi, Scott D, Porter, Adeline R, DeLeo, Frank R, Nauseef, William M

“…Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pose a significant threat to human health. Polymorphonuclear leukocytes (PMN) are…”
Get full text

Staphylococcal alpha‐phenol soluble modulins contribute to neutrophil lysis after phagocytosis by Surewaard, B. G. J., Haas, C. J. C., Vervoort, F., Rigby, K. M., DeLeo, F. R., Otto, M., Strijp, J. A. G., Nijland, R.

“…Summary Staphylococcus aureus community‐acquired (CA) MRSA strains are highly virulent and can cause infections in otherwise healthy individuals. The most…”
Get full text

Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics by Ventura, Christy L, Malachowa, Natalia, Hammer, Carl H, Nardone, Glenn A, Robinson, Mary Ann, Kobayashi, Scott D, DeLeo, Frank R

“…Staphylococcus aureus is a prominent human pathogen and leading cause of bacterial infection in hospitals and the community. Community-associated…”
Get full text

Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus by Uhlemann, Anne-Catrin, Otto, Michael, Lowy, Franklin D., DeLeo, Frank R.

“…•Genomics and evolutionary history of the CC30 lineage.•Emergence of ST239 and basis for success.•USA300 genomics and evolution. Staphylococcus aureus is a…”
Get full text

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance by Sully, Erin K, Malachowa, Natalia, Elmore, Bradley O, Alexander, Susan M, Femling, Jon K, Gray, Brian M, DeLeo, Frank R, Otto, Michael, Cheung, Ambrose L, Edwards, Bruce S, Sklar, Larry A, Horswill, Alexander R, Hall, Pamela R, Gresham, Hattie D

“…Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused…”
Get full text

Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps by Malachowa, Natalia, Kobayashi, Scott D, Freedman, Brett, Dorward, David W, DeLeo, Frank R

“…Staphylococcus aureus secretes numerous virulence factors that facilitate evasion of the host immune system. Among these molecules are pore-forming cytolytic…”
Get full text

Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies by Opoku-Temeng, Clement, Malachowa, Natalia, Kobayashi, Scott D., DeLeo, Frank R.

“…Klebsiella pneumoniae (K. pneumoniae) is a Gram-negative commensal bacterium and opportunistic pathogen. In healthy individuals, the innate immune system is…”
Get full text

Global changes in Staphylococcus aureus gene expression in human blood by Malachowa, Natalia, Whitney, Adeline R, Kobayashi, Scott D, Sturdevant, Daniel E, Kennedy, Adam D, Braughton, Kevin R, Shabb, Duncan W, Diep, Binh An, Chambers, Henry F, Otto, Michael, DeLeo, Frank R

“…Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as…”
Get full text

A molecular trigger for intercontinental epidemics of group A Streptococcus by Zhu, Luchang, Olsen, Randall J, Nasser, Waleed, Beres, Stephen B, Vuopio, Jaana, Kristinsson, Karl G, Gottfredsson, Magnus, Porter, Adeline R, DeLeo, Frank R, Musser, James M

“…The identification of the molecular events responsible for strain emergence, enhanced virulence, and epidemicity has been a long-pursued goal in infectious…”
Get full text

Klebsiella pneumoniae capsule polysaccharide as a target for therapeutics and vaccines by Opoku-Temeng, Clement, Kobayashi, Scott D., DeLeo, Frank R.

“…[Display omitted] Carbapenem-resistant (CR) Klebsiella pneumoniae has emerged as an urgent public health threat in many industrialized countries worldwide,…”
Get full text

Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus by Li, Min, Diep, Binh An, Villaruz, Amer E, Braughton, Kevin R, Jiang, Xiaofei, DeLeo, Frank R, Chambers, Henry F, Lu, Yuan, Otto, Michael

“…Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged worldwide. The United States, in particular, is experiencing a…”
Get full text