Search Results - "Delcros, Jean‐Guy"

From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors by Kryza, David, Wischhusen, Jennifer, Richaud, Mathieu, Hervieu, Maëva, Sidi Boumedine, Jacqueline, Delcros, Jean‐Guy, Besse, Sophie, Baudier, Thomas, Laval, Pierre‐Alexandre, Breusa, Silvia, Boutault, Erwan, Clermidy, Hugo, Rama, Nicolas, Ducarouge, Benjamin, Devouassoux‐Shisheboran, Mojgan, Chezal, Jean‐Michel, Giraudet, Anne‐Laure, Walter, Thomas, Mehlen, Patrick, Sarrut, David, Gibert, Benjamin

“…Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors…”
Get full text

Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules by Gorny, Hubert, Mularoni, Angélique, Delcros, Jean-Guy, Freton, Céline, Preto, Jordane, Krimm, Isabelle

“…The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target…”
Get full text

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes by Reuten, Raphael, Patel, Trushar R., McDougall, Matthew, Rama, Nicolas, Nikodemus, Denise, Gibert, Benjamin, Delcros, Jean-Guy, Prein, Carina, Meier, Markus, Metzger, Stéphanie, Zhou, Zhigang, Kaltenberg, Jennifer, McKee, Karen K., Bald, Tobias, Tüting, Thomas, Zigrino, Paola, Djonov, Valentin, Bloch, Wilhelm, Clausen-Schaumann, Hauke, Poschl, Ernst, Yurchenco, Peter D., Ehrbar, Martin, Mehlen, Patrick, Stetefeld, Jörg, Koch, Manuel

“…Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the…”
Get full text

Non-canonical NOTCH3 signalling limits tumour angiogenesis by Lin, Shuheng, Negulescu, Ana, Bulusu, Sirisha, Gibert, Benjamin, Delcros, Jean-Guy, Ducarouge, Benjamin, Rama, Nicolas, Gadot, Nicolas, Treilleux, Isabelle, Saintigny, Pierre, Meurette, Olivier, Mehlen, Patrick

“…Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies to inhibit the so-called canonical pathway. Here we…”
Get full text

Targeting netrin‐3 in small cell lung cancer and neuroblastoma by Jiang, Shan, Richaud, Mathieu, Vieugué, Pauline, Rama, Nicolas, Delcros, Jean‐Guy, Siouda, Maha, Sanada, Mitsuaki, Redavid, Anna‐Rita, Ducarouge, Benjamin, Hervieu, Maëva, Breusa, Silvia, Manceau, Ambroise, Gattolliat, Charles‐Henry, Gadot, Nicolas, Combaret, Valérie, Neves, David, Ortiz‐Cuaran, Sandra, Saintigny, Pierre, Meurette, Olivier, Walter, Thomas, Janoueix‐Lerosey, Isabelle, Hofman, Paul, Mulligan, Peter, Goldshneider, David, Mehlen, Patrick, Gibert, Benjamin

“…The navigation cue netrin‐1 is well‐documented for its key role in cancer development and represents a promising therapeutic target currently under clinical…”
Get full text

Inhibition of Endothelial Cell Apoptosis by Netrin-1 during Angiogenesis by Castets, Marie, Coissieux, Marie-May, Delloye-Bourgeois, Céline, Bernard, Laure, Delcros, Jean-Guy, Bernet, Agnès, Laudet, Vincent, Mehlen, Patrick

“…Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory…”
Get full text

Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity by Delloye-Bourgeois, Céline, Gibert, Benjamin, Rama, Nicolas, Delcros, Jean-Guy, Gadot, Nicolas, Scoazec, Jean-Yves, Krauss, Robert, Bernet, Agnès, Mehlen, Patrick

“…The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has…”
Get full text

Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas by Broutier, Laura, Creveaux, Marion, Vial, Jonathan, Tortereau, Antonin, Delcros, Jean‐Guy, Chazot, Guillaume, McCarron, Mark J, Léon, Sophie, Pangault, Céline, Gadot, Nicolas, Colombe, Amélie, Boulland, Marie‐Laure, Blachier, Jonathan, Marie, Julien C, Traverse‐Glehen, Alexandra, Donzé, Olivier, Chassagne‐Clément, Catherine, Salles, Gilles, Tarte, Karin, Mehlen, Patrick, Castets, Marie

“…DCC ( Deleted in Colorectal Carcinoma ) has been demonstrated to constrain tumor progression by inducing apoptosis unless engaged by its ligand netrin‐1. This…”
Get full text

Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression by Paradisi, Andrea, Maisse, Carine, Coissieux, Marie-May, Gadot, Nicolas, Lépinasse, Florian, Delloye-Bourgeois, Céline, Delcros, Jean-Guy, Svrcek, Magali, Neufert, Clemens, Fléjou, Jean-François, Scoazec, Jean-Yves, Mehlen, Patrick

“…Chronic inflammation and cancer are intimately associated. This is particularly true for inflammatory bowel diseases (IBD), such as ulcerative colitis and…”
Get full text

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin‐1 interference by Grandin, Mélodie, Mathot, Pauline, Devailly, Guillaume, Bidet, Yannick, Ghantous, Akram, Favrot, Clementine, Gibert, Benjamin, Gadot, Nicolas, Puisieux, Isabelle, Herceg, Zdenko, Delcros, Jean‐Guy, Bernet, Agnès, Mehlen, Patrick, Dante, Robert

“…In a number of human cancers, NTN1 upregulation inhibits apoptosis induced by its so‐called dependence receptors DCC and UNC5H, thus promoting tumor…”
Get full text

Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues by Ulisse, Salvatore, Delcros, Jean‐Guy, Baldini, Enke, Toller, Matteo, Curcio, Francesco, Giacomelli, Laura, Prigent, Claude, Ambesi‐Impiombato, Francesco S., D'Armiento, Massimino, Arlot‐Bonnemains, Yannick

“…The Aurora kinases are involved in the regulation of cell cycle progression, and alterations in their expression have been shown to associate with cell…”
Get full text

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket by Bancet, Alexandre, Frem, Rita, Jeanneret, Florian, Mularoni, Angélique, Bazelle, Pauline, Roelants, Caroline, Delcros, Jean-Guy, Guichou, Jean-François, Pillet, Catherine, Coste, Isabelle, Renno, Toufic, Battail, Christophe, Cochet, Claude, Lomberget, Thierry, Filhol, Odile, Krimm, Isabelle

“…Although the involvement of protein kinase CK2 in cancer is well-documented, there is a need for selective CK2 inhibitors suitable for investigating CK2…”
Get full text

Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis by Bouzas-Rodriguez, Jimena, Cabrera, Jorge Ruben, Delloye-Bourgeois, Céline, Ichim, Gabriel, Delcros, Jean-Guy, Raquin, Marie-Anne, Rousseau, Raphaël, Combaret, Valérie, Bénard, Jean, Tauszig-Delamasure, Servane, Mehlen, Patrick

“…Tropomyosin-related kinase receptor C (TrkC) is a neurotrophin receptor with tyrosine kinase activity that was expected to be oncogenic. However, it has…”
Get full text

Synthesis and cytotoxic activities of usnic acid derivatives by Bazin, Marc-Antoine, Lamer, Anne-Cécile Le, Delcros, Jean-Guy, Rouaud, Isabelle, Uriac, Philippe, Boustie, Joël, Corbel, Jean-Charles, Tomasi, Sophie

“…Cytotoxic evaluation of enamines derived from (+)-usnic acid led us to the selection of the diaminooctane derivative as active towards cancer cell lines (2.7 <…”
Get full text

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2 by Alchab, Faten, Ettouati, Laurent, Bouaziz, Zouhair, Bollacke, Andre, Delcros, Jean-Guy, Gertzen, Christoph G W, Gohlke, Holger, Pinaud, Noël, Marchivie, Mathieu, Guillon, Jean, Fenet, Bernard, Jose, Joachim, Borgne, Marc Le

“…Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2…”
Get full text

Synthesis and Biological Evaluation of N -(Anthracen-9-ylmethyl)triamines as Molecular Recognition Elements for the Polyamine Transporter by Wang, Chaojie, Delcros, Jean-Guy, Biggerstaff, John, Phanstiel

“…An efficient modular synthesis of N1-substituted triamines containing different tether lengths between nitrogen centers was developed. A series of N…”
Get full text

Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC) by Martin, Benedicte, Chesnel, Franck, Delcros, Jean-Guy, Jouan, Florence, Couturier, Anne, Dugay, Frederic, Le Goff, Xavier, Patard, Jean-Jacques, Fergelot, Patricia, Vigneau, Cecile, Rioux-Leclerq, Nathalie, Arlot-Bonnemains, Yannick

“…Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of kidney cancer and is often characterized by mutations or deletions of the…”
Get full text

Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines by Arlot-Bonnemains, Yannick, Baldini, Enke, Martin, Benedicte, Delcros, Jean-Guy, Toller, Matteo, Curcio, Francesco, Ambesi-Impiombato, Francesco S, D'Armiento, Massimino, Ulisse, Salvatore

“…Anaplastic thyroid cancers (ATC) are aggressive tumors, which exhibit cell cycle misregulations leading to uncontrolled cellular proliferation and genomic…”
Get full text

Correction: Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC) by Martin, Benedicte, Chesnel, Franck, Delcros, Jean-Guy, Jouan, Florence, Couturier, Anne, Dugay, Frederic, Le Goff, Xavier, Patard, Jean-Jacques, Fergelot, Patricia, Vigneau, Cecile, Rioux-Leclerq, Nathalie, Arlot-Bonnemains, Yannick

Get full text

Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues by Ulisse, Salvatore, Baldini, Enke, Toller, Matteo, Delcros, Jean-Guy, Guého, Aurélie, Curcio, Francesco, De Antoni, Enrico, Giacomelli, Laura, Ambesi-Impiombato, Francesco S, Bocchini, Sarah, D’Armiento, Massimino, Arlot-Bonnemains, Yannick

“…Aurora-A kinase has recently been shown to be deregulated in thyroid cancer cells and tissues. Among the Aurora-A substrates identified, transforming acidic…”
Get full text