Search Results - "Delcayre, Claude"
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Inhibition of Galectin-3 Pathway Prevents Isoproterenol-Induced Left Ventricular Dysfunction and Fibrosis in Mice
Published in Hypertension (Dallas, Tex. 1979) (01-03-2016)“…Galectin-3 (Gal-3) is involved in inflammation, fibrogenesis, and cardiac remodeling. Previous evidence shows that Gal-3 interacts with aldosterone in…”
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2
Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
Published in JACC. Basic to translational science (01-10-2019)“…[Display omitted] •In 2 different mouse models, AKI increased Gal-3 expression and induced cardiac dysfunction, cardiac and systemic inflammation, cardiac…”
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3
Aldosterone Inhibits Antifibrotic Factors in Mouse Hypertensive Heart
Published in Hypertension (Dallas, Tex. 1979) (01-06-2012)“…The renin-angiotensin-aldosterone system is involved in the arterial hypertension-associated cardiovascular remodeling. In this context, the development of…”
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4
Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo
Published in Hypertension (Dallas, Tex. 1979) (01-02-2013)“…Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleterious effects of…”
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5
Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure
Published in American journal of physiology. Heart and circulatory physiology (01-02-2009)“…We tested the hypothesis that heart rate (HR) reduction, induced by the selective hyperpolarization-activated current inhibitor ivabradine (Iva), might improve…”
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6
Effects of biological sex on the pathophysiology of the heart
Published in British journal of pharmacology (01-02-2014)“…Cardiovascular diseases are the leading causes of death in men and women in industrialized countries. While the effects of biological sex on cardiovascular…”
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7
Cross-Talk Between Mineralocorticoid and Angiotensin II Signaling for Cardiac Remodeling
Published in Hypertension (Dallas, Tex. 1979) (01-12-2008)“…Experimental and clinical studies show that aldosterone/mineralocorticoid receptor (MR) activation has deleterious effects in the cardiovascular system that…”
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8
Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias
Published in Circulation (New York, N.Y.) (14-06-2005)“…Life-threatening cardiac arrhythmia is a major source of mortality worldwide. Besides rare inherited monogenic diseases such as long-QT or Brugada syndromes,…”
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9
Akt‐mediated cardioprotective effects of aldosterone in type 2 diabetic mice
Published in The FASEB journal (01-06-2014)“…ABSTRACT Studies have shown that aldosterone would have angiogenic effects and therefore would be beneficial in the context of cardiovascular diseases. We thus…”
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10
Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice
Published in PloS one (30-05-2012)“…Arterial hypertension (AH) induces cardiac hypertrophy and reactivation of "fetal" gene expression. In rodent heart, alpha-Myosin Heavy Chain (MyHC) and its…”
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11
Molecular mechanisms in evolutionary cardiology failure
Published in Annals of the New York Academy of Sciences (01-02-2010)“…Integration of the relevant evolutionary paradigm in cardiology has not yet been fully achieved: In the past, heart failure (HF) was mainly ascribed to…”
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12
Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats
Published in Molecular and cellular biochemistry (01-01-2011)“…Hyperhomocysteinemia, characterized by an elevated plasma homocysteine concentration, leads to several clinical manifestations and particularly cardiovascular…”
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13
Aldosterone promotes cardiac endothelial cell proliferation in vivo
Published in Journal of the American Heart Association (06-01-2015)“…Experimentally, aldosterone in association with NaCl induces cardiac fibrosis, oxidative stress, and inflammation through mineralocorticoid receptor…”
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14
Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice
Published in Circulation (New York, N.Y.) (28-09-2004)“…Elevated circulating aldosterone level is associated with impaired cardiovascular function. Although the mechanisms are not fully understood, aldosterone…”
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15
Aldosterone enhances ischemia-induced neovascularization through angiotensin II-dependent pathway
Published in Circulation (New York, N.Y.) (27-04-2004)“…We analyzed the role of aldosterone in ischemia-induced neovascularization and the involvement of angiotensin II (Ang II) signaling in this effect. Ischemia…”
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16
Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice
Published in The Journal of nutritional biochemistry (01-09-2011)“…Hyperhomocysteinemia leads to several clinical manifestations and, particularly, liver disease. Lowering homocysteine through nutrition or other means might…”
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17
Reversible Cardiac Fibrosis and Heart Failure Induced by Conditional Expression of an Antisense mRNA of the Mineralocorticoid Receptor in Cardiomyocytes
Published in Proceedings of the National Academy of Sciences - PNAS (14-05-2002)“…Cardiac failure is a common feature in the evolution of cardiac disease. Among the determinants of cardiac failure, the reninangiotensin-aldosterone system has…”
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18
Expression and Modulation of Steroidogenic Acute Regulatory Protein Messenger Ribonucleic Acid in Rat Cardiocytes and after Myocardial Infarction
Published in Endocrinology (Philadelphia) (01-05-2003)“…We examined whether the mRNA for steroidogenic acute regulatory (StAR) protein, a crucial factor in the rate-limiting step of aldosterone biosynthesis, is…”
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19
Aldosterone, mineralocorticoid receptor, and heart failure
Published in Molecular and cellular endocrinology (24-03-2012)“…► We review aldosterone and mineralocorticoid receptor actions in the heart. ► Recent findings from clinical trials and animal studies are discussed. ►…”
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The Mineralocorticoid Receptor in Heart: Different Effects in Different Cells
Published in Hypertension (Dallas, Tex. 1979) (01-04-2011)Get full text
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