Search Results - "Delbridge, Lea M. D"

Myocardial stress and autophagy: mechanisms and potential therapies by Delbridge, Lea M. D., Mellor, Kimberley M., Taylor, David J., Gottlieb, Roberta A.

“…Key Points Autophagic breakdown of cellular components is regulated by multiple signalling networks, including insulin and 5′-AMP-activated protein kinase…”
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A novel small molecule inhibitor of human Drp1 by Rosdah, Ayeshah A., Abbott, Belinda M., Langendorf, Christopher G., Deng, Yali, Truong, Jia Q., Waddell, Helen M. M., Ling, Naomi X. Y., Smiles, William J., Delbridge, Lea M. D., Liu, Guei-Sheung, Oakhill, Jonathan S., Lim, Shiang Y., Holien, Jessica K.

“…Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous…”
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Macrophage Mineralocorticoid Receptor Signaling Plays a Key Role in Aldosterone-Independent Cardiac Fibrosis by Bienvenu, Laura A, Morgan, James, Rickard, Amanda J, Tesch, Greg H, Cranston, Greg A, Fletcher, Elizabeth K, Delbridge, Lea M. D, Young, Morag J

“…Mineralocorticoid receptor (MR) activation promotes the development of cardiac fibrosis and heart failure. Clinical evidence demonstrates that MR antagonism is…”
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Myocardial autophagic energy stress responses--macroautophagy, mitophagy, and glycophagy by Delbridge, Lea M D, Mellor, Kimberley M, Taylor, David J R, Gottlieb, Roberta A

“…An understanding of the role of autophagic processes in the management of cardiac metabolic stress responses is advancing rapidly and progressing beyond a…”
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Cellular Mechanisms Mediating Exercise-Induced Protection against Cardiotoxic Anthracycline Cancer Therapy by Dozic, Sanela, Howden, Erin J, Bell, James R, Mellor, Kimberley M, Delbridge, Lea M D, Weeks, Kate L

“…Anthracyclines such as doxorubicin are widely used chemotherapy drugs. A common side effect of anthracycline therapy is cardiotoxicity, which can compromise…”
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Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro by Daniels, Lorna J., Annandale, Marco, Koutsifeli, Parisa, Li, Xun, Bussey, Carol T., van Hout, Isabelle, Bunton, Richard W., Davis, Philip J., Coffey, Sean, Katare, Rajesh, Lamberts, Regis R., Delbridge, Lea M. D., Mellor, Kimberley M.

“…Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct…”
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Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte by Bienvenu, Laura A, Reichelt, Melissa E, Delbridge, Lea M D, Young, Morag J

“…MR (mineralocorticoid receptor) activation in the heart plays a central role in the development of cardiovascular disease, including heart failure. The MR is…”
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Aromatase Deficiency Confers Paradoxical Postischemic Cardioprotection by Bell, James R, Mellor, Kimberley M, Wollermann, Amanda C, Ip, Wendy T. K, Reichelt, Melissa E, Meachem, Sarah J, Simpson, Evan R, Delbridge, Lea M. D

“…The conventional view is that estrogen confers female cardioprotection. Estrogen synthesis depends on androgen availability, with aromatase regulating…”
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Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice by Bell, James R, Bernasochi, Gabriel B, Varma, Upasna, Boon, Wah Chin, Ellem, Stuart J, Risbridger, Gail P, Delbridge, Lea M D

“…Estrogen in females is conventionally considered a cardioprotective influence, but a role for estrogen in male cardioprotection has yet to be defined. Estrogen…”
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Fructose modulates cardiomyocyte excitation-contraction coupling and Ca²⁺ handling in vitro by Mellor, Kimberley M, Bell, James R, Wendt, Igor R, Davidoff, Amy J, Ritchie, Rebecca H, Delbridge, Lea M D

“…High dietary fructose has structural and metabolic cardiac impact, but the potential for fructose to exert direct myocardial action is uncertain. Cardiomyocyte…”
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Myocardial glycogen dynamics: New perspectives on disease mechanisms by Chandramouli, Chanchal, Varma, Upasna, Stevens, Ellie M, Xiao, Rui-Ping, Stapleton, David I, Mellor, Kimberley M, Delbridge, Lea MD

“…Summary Cardiac glycogen regulation involves a complex interplay between multiple signalling pathways, allosteric activation of enzymes, and sequestration for…”
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Ca2+ /calmodulin-dependent protein kinase inhibition suppresses post-ischemic arrhythmogenesis and mediates sinus bradycardic recovery in reperfusion by Bell, James R, Curl, Claire L, Ip, Wendy T.K, Delbridge, Lea M.D

“…Abstract Background Ca2+ /calmodulin-dependent protein kinase (CaMKII) activation is known to be associated with conditions where the incidence of arrhythmias…”
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Elevated dietary sugar and the heart: experimental models and myocardial remodeling by Mellor, Kimberley M, Ritchie, Rebecca H, Davidoff, Amy J, Delbridge, Lea M D

“…A dramatic rise in the prevalence of insulin resistance has been paralleled by increasing dietary consumption of sugar. The use of added sweeteners containing…”
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Reactive oxygen species and insulin-resistant cardiomyopathy by Mellor, Kimberley M, Ritchie, Rebecca H, Delbridge, Lea MD

“…Summary 1. The prevalence of insulin resistance has increased markedly in the past decade and is known to be associated with cardiovascular risk. Evidence of…”
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A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology by Weeks, Kate L., Kiriazis, Helen, Wadley, Glenn D., Masterman, Emma I., Sergienko, Nicola M., Raaijmakers, Antonia J. A., Trewin, Adam J., Harmawan, Claudia A., Yildiz, Gunes S., Liu, Yingying, Drew, Brian G., Gregorevic, Paul, Delbridge, Lea M. D., McMullen, Julie R., Bernardo, Bianca C.

“…Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a higher risk of developing heart…”
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Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture by Ghosh, Shouryadipta, Tran, Kenneth, Delbridge, Lea M D, Hickey, Anthony J R, Hanssen, Eric, Crampin, Edmund J, Rajagopal, Vijay

“…Recent electron microscopy data have revealed that cardiac mitochondria are not arranged in crystalline columns but are organised with several mitochondria…”
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Myocardial insulin resistance, metabolic stress and autophagy in diabetes by Mellor, Kimberley M, Bell, James R, Ritchie, Rebecca H, Delbridge, Lea MD

“…Summary Clinical studies in humans strongly support a link between insulin resistance and non‐ischaemic heart failure. The occurrence of a specific…”
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Cardiomyocyte glycophagy is regulated by insulin and exposure to high extracellular glucose by Mellor, Kimberley M, Varma, Upasna, Stapleton, David I, Delbridge, Lea M D

“…Disturbed systemic glycemic and insulinemic status elicits cardiomyocyte metabolic stress and altered glucose handling. In diabetes, pathological myocardial…”
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Mitochondrial fission – a drug target for cytoprotection or cytodestruction? by Rosdah, Ayeshah A., K. Holien, Jessica, Delbridge, Lea M. D., Dusting, Gregory J., Lim, Shiang Y.

“…Mitochondria are morphologically dynamic organelles constantly undergoing processes of fission and fusion that maintain integrity and bioenergetics of the…”
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New Perspectives on Sex Steroid and Mineralocorticoid Receptor Signaling in Cardiac Ischemic Injury by Bienvenu, Laura A., Bell, James R., Weeks, Kate L., Delbridge, Lea M. D., Young, Morag J.

“…The global burden of ischemic heart disease is burgeoning for both men and women. Although advances have been made, the need for new sex-specific therapies…”
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