Search Results - "Delbecq, Scott"

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the 'IxI' motif by Delbecq, Scott P, Jehle, Stefan, Klevit, Rachel

“…Small heat shock proteins (sHSPs) play a central role in protein homeostasis under conditions of stress by binding partly unfolded, aggregate‐prone proteins…”
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One size does not fit all: The oligomeric states of αB crystallin by Delbecq, Scott P., Klevit, Rachel E.

“…Small Heat Shock Proteins (sHSPs) are a diverse family of molecular chaperones that delay protein aggregation through interactions with non-native and…”
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HSPB5 engages multiple states of a destabilized client to enhance chaperone activity in a stress-dependent manner by Delbecq, Scott P., Klevit, Rachel E.

“…Small heat shock proteins (sHSPs) delay protein aggregation in an ATP-independent manner by interacting with client proteins that are in states susceptible to…”
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A Mechanism of Subunit Recruitment in Human Small Heat Shock Protein Oligomers by Delbecq, Scott P, Rosenbaum, Joel C, Klevit, Rachel E

“…Small heat shock proteins (sHSPs) make up a class of molecular chaperones broadly observed across organisms. Many sHSPs form large oligomers that undergo…”
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The ubiquitin ligase SspH1 from Salmonella uses a modular and dynamic E3 domain to catalyze substrate ubiquitylation by Cook, Matt, Delbecq, Scott P., Schweppe, Thomas P., Guttman, Miklos, Klevit, Rachel E., Brzovic, Peter S.

“…SspH/IpaH bacterial effector E3 ubiquitin (Ub) ligases, unrelated in sequence or structure to eukaryotic E3s, are utilized by a wide variety of Gram-negative…”
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A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis by Rajagopal, Ponni, Tse, Eric, Borst, Andrew J, Delbecq, Scott P, Shi, Lei, Southworth, Daniel R, Klevit, Rachel E

“…Small heat shock proteins (sHSPs) are essential 'holdase' chaperones that form large assemblies and respond dynamically to pH and temperature stresses to…”
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Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence by Hicks, Kevin G, Delbecq, Scott P, Sancho-Vaello, Enea, Blanc, Marie-Pierre, Dove, Katja K, Prost, Lynne R, Daley, Margaret E, Zeth, Kornelius, Klevit, Rachel E, Miller, Samuel I

“…Salmonella PhoQ is a histidine kinase with a periplasmic sensor domain (PD) that promotes virulence by detecting the macrophage phagosome. PhoQ activity is…”
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Modeling and Design Optimization of an Electric Environmental Control System for Commercial Passenger Aircraft by Planès, Thomas, Delbecq, Scott, Pommier-Budinger, Valérie, Bénard, Emmanuel

“…The aircraft environmental control system (ECS) is the second-highest fuel consumer system, behind the propulsion system. To reduce fuel consumption, one…”
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1384 LNK101, a highly differentiated T-cell engager (TCE) targeting CD3 and mesothelin (MSLN) in solid tumors by Santiago, Linda, Bandaranayake, Ashok, Correnti, Colin, Lin, Ida, Chan, Man Kid, Delbecq, Scott, Clarke, Midori, Carter, Jane, Gruff, Eric, Bracken, William, Meininger, David, Hausman, Diana, Mehlin, Christopher

“…BackgroundMSLN is a membrane protein overexpressed by many cancers with limited expression in normal tissues. One challenge in developing MSLN-targeted…”
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Benchmarking of monolithic MDO formulations and derivative computation techniques using OpenMDAO by Delbecq, Scott, Budinger, Marc, Reysset, Aurélien

“…The design optimization of coupled systems requires the implementation of multidisciplinary design optimization techniques in order to obtain consistent and…”
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Lightweight climate models could be useful for assessing aviation mitigation strategies and moving beyond the CO2-equivalence metrics debate by Arriolabengoa, Sara, Planès, Thomas, Mattei, Philippe, Cariolle, Daniel, Delbecq, Scott

“…Assessing mitigation strategies for aviation is a critical issue for the aviation stakeholders, while the debate continues on the most appropriate…”
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Efficient sizing and optimization of multirotor drones based on scaling laws and similarity models by Delbecq, S., Budinger, M., Ochotorena, A., Reysset, A., Defay, F.

“…In contrast to the current overall aircraft design techniques, the design of multirotor vehicles generally consists of skill-based selection procedures or is…”
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Scaling laws and similarity models for the preliminary design of multirotor drones by Budinger, M., Reysset, A., Ochotorena, A., Delbecq, S.

“…Multirotor drones modelling and parameter estimation have gained great interest because of their vast application for civil, industrial, military and…”
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A methodology to integrate reliability into the conceptual design of safety-critical multirotor unmanned aerial vehicles by Liscouët, Jonathan, Pollet, Félix, Jézégou, Joël, Budinger, Marc, Delbecq, Scott, Moschetta, Jean-Marc

“…This article introduces a new conceptual design methodology to evaluate and explore underactuated electric multirotor unmanned aerial vehicle (UAV) designs for…”
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Simulation and evaluation of sustainable climate trajectories for aviation by Planès, T., Delbecq, S., Pommier-Budinger, V., Bénard, E.

“…In 2019, aviation was responsible for 2.6% of world CO2 emissions as well as additional climate impacts such as contrails. Like all industrial sectors, the…”
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One size doesn't fit all: the oligomeric states of αB crystallin by Delbecq, Scott P., Klevit, Rachel E.

“…Small Heat Shock Proteins (sHSPs) are a diverse family of molecular chaperones that delay protein aggregation through interactions with nonnative and…”
Get full text

Binding determinants of the small heat shock protein, [alpha]B-crystallin: recognition of the 'IxI' motif by Delbecq, Scott P, Jehle, Stefan, Klevit, Rachel

“…Small heat shock proteins (sHSPs) play a central role in protein homeostasis under conditions of stress by binding partly unfolded, aggregate-prone proteins…”
Get full text

A De Novo Protein Binding Pair By Computational Design and Directed Evolution by Karanicolas, John, Corn, Jacob E., Chen, Irwin, Joachimiak, Lukasz A., Dym, Orly, Peck, Sun H., Albeck, Shira, Unger, Tamar, Hu, Wenxin, Liu, Gaohua, Delbecq, Scott, T. Montelione, Gaetano, P. Spiegel, Clint, Liu, David R., Baker, David

“…The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would…”
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A pH‐dependent Switch Regulates Chaperone Activity by Rajagopal, Ponni, Jehle, Stefan, Dove, Katja, Pierini, Chris, Delbecq, Scott, Klevit, Rachel E

“…Hypoxic conditions often found in cancerous and ischemic cells induce the over‐expression of a non‐ATP dependent stress chaperone, αB‐Crystallin (αB)…”
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Defining Protein Interactions With Small Heat Shock Proteins by Delbecq, Scott P

“…Small heat shock proteins (sHSPs) are a class of molecular chaperones broadly observed across organisms where they play a central role in maintaining protein…”
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