Search Results - "Delatouche, Régis"

Synthesis of 2-Mercapto-(2-Oxoindolin-3-Ylidene)Acetonitriles from 3-(4-Chloro-5 H -1,2,3-Dithiazol-5-Ylidene)Indolin-2-ones by Letribot, Boris, Delatouche, Régis, Rouillard, Hervé, Bonnet, Antoine, Chérouvrier, Jean-René, Domon, Lisianne, Besson, Thierry, Thiéry, Valérie

“…Alkylidene oxindoles are important functional moieties and building blocks in pharmaceutical and synthetic chemistry. Our interest in biologically active…”
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Nanoparticles Produced by Ring-Opening Metathesis Polymerization Using Norbornenyl-poly(ethylene oxide) as a Ligand-Free Generic Platform for Highly Selective In Vivo Tumor Targeting by Gueugnon, Fabien, Denis, Iza, Pouliquen, Daniel, Collette, Floraine, Delatouche, Régis, Héroguez, Valérie, Grégoire, Marc, Bertrand, Philippe, Blanquart, Christophe

“…We described a norbornenyl-poly(ethylene oxide) nanoparticles ligand-free generic platform, made fluorescent with straightforward preparation by ring-opening…”
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Vorinostat–Polymer Conjugate Nanoparticles for Acid-Responsive Delivery and Passive Tumor Targeting by Denis, Iza, el Bahhaj, Fatima, Collette, Floraine, Delatouche, Régis, Gueugnon, Fabien, Pouliquen, Daniel, Pichavant, Loic, Héroguez, Valérie, Grégoire, Marc, Bertrand, Philippe, Blanquart, Christophe

“…In vivo histone deacetylase (HDAC) inhibition by vorinostat under clinically acceptable dosing is limited by its poor pharmacokinetics properties. A new type…”
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Measuring Angiotensin‑I Converting Enzyme Inhibitory Activity by Micro Plate Assays: Comparison Using Marine Cryptides and Tentative Threshold Determinations with Captopril and Losartan by Henda, Yesmine Ben, Labidi, Anis, Arnaudin, Ingrid, Bridiau, Nicolas, Delatouche, Régis, Maugard, Thierry, Piot, Jean-Marie, Sannier, Frédéric, Thiéry, Valérie, Bordenave-Juchereau, Stéphanie

“…To determine the angiotensin-I converting enzyme (ACE) inhibitory activity of marine cryptides, different methods were tested. ACE inhibition was measured…”
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Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery by Denis, Iza, el Bahhaj, Fatima, Collette, Floraine, Delatouche, Régis, Gueugnon, Fabien, Pouliquen, Daniel, Pichavant, Loic, Héroguez, Valérie, Grégoire, Marc, Bertrand, Philippe, Blanquart, Christophe

“…We report the synthesis of acid–responsive polymeric nanoparticles (NPs) consisting of a polymer-histone deacetylase inhibitor conjugate. An innovative aspect…”
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Bifunctional 2,5-Diketopiperazines as Rigid Three-Dimensional Scaffolds in Receptors and Peptidomimetics by Ressurreição, Ana Sofia M., Delatouche, Régis, Gennari, Cesare, Piarulli, Umberto

“…2,5‐Diketopiperazines (DKPs) are heterocyclic scaffolds easily accessible from α‐amino acids and characterized by rather flat six‐membered‐ring cores that can…”
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Improved racemate resolution of pentan-2-ol and trans-(Z)-cyclooct-5-ene-1,2-diol by lipase catalysis by Graber, Marianne, Rouillard, Hervé, Delatouche, Régis, Fniter, Najla, Belkhiria, Belsem, Bonnet, Antoine, Domon, Lisianne, Thiéry, Valérie

“…•Acyl donor structure changes lipase enantioselectivity during acylation reactions.•Sol-gel encapsulation of lipase may increase enzyme…”
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Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy by El Bahhaj, Fatima, Denis, Iza, Pichavant, Loic, Delatouche, Régis, Collette, Floraine, Linot, Camille, Pouliquen, Daniel, Grégoire, Marc, Héroguez, Valérie, Blanquart, Christophe, Bertrand, Philippe

“…Fast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present…”
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Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy by Delatouche, Régis, Denis, Iza, Grinda, Marion, Bahhaj, Fatima El, Baucher, Estelle, Collette, Floraine, Héroguez, Valérie, Grégoire, Marc, Blanquart, Christophe, Bertrand, Philippe

“…The aim of this study was to develop clickable prodrugs bearing a tunable pH responsive linker designed for acidic pH-mediated release of histone deacetylase…”
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Foldamers of bifunctional diketopiperazines displaying a β-bend ribbon structure by Delatouche, Régis, Durini, Marco, Civera, Monica, Belvisi, Laura, Piarulli, Umberto

“…The conformational preferences of oligomeric ( DKP-1) n were studied by 1H NMR, CD, and molecular modeling, revealing a sequence of reverse turns with…”
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Triazolyl Derivatives for Acidic Release of Alcohols by Mondon, Martine, Delatouche, Régis, Bachmann, Christian, Frapper, Gilles, Len, Christophe, Bertrand, Philippe

“…New triazolyl‐based carbonates and ethers have been investigated as potential alcohol‐releasing systems under mild acidic conditions. Triazolyl carbonates…”
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Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel Cathepsin D substrate for simultaneous cancer diagnosis and therapy by Achour, Oussama, Bridiau, Nicolas, Kacem, Meriem, Delatouche, Régis, Bordenave-Juchereau, Stéphanie, Sannier, Frédéric, Thiéry, Valérie, Piot, Jean-Marie, Maugard, Thierry, Arnaudin, Ingrid

“…Pro-Cathepsin D (pCD) is an aspartyl endopeptidase which is over expressed in many cancers. This over expression generally led to its secretion into the…”
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Easy and effective method to produce functionalized particles for cellular uptake by Collette, Floraine, Delatouche, Régis, Blanquart, Christophe, Gueugnon, Fabien, Grégoire, Marc, Bertrand, Philippe, Héroguez, Valérie

“…In this contribution, a versatile approach for the synthesis of functionalized particles for drug delivery is presented, using two nonaggressive standardized…”
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Novel triazolyl derivatives for acidic release of amines by Delatouche, Regis, Mondon, Martine, Gil, Adrià, Frapper, Gilles, Bachmann, Christian, Bertrand, Philippe

“…Triazolyl derivatives of amines were prepared using click chemistry and evaluated as releasing systems in mildly acidic environments. Triazolylcarbamates and…”
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